Results 71 to 80 of about 2,554 (268)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

FAST Discovery of Eight Isolated Millisecond Pulsars in NGC 6517

The Astrophysical Journal Letters
We present the discovery of eight isolated millisecond pulsars in globular cluster (GC) NGC 6517 using the Five-hundred-meter Aperture Spherical radio Telescope (FAST).
Dejiang Yin, Li-yun Zhang, Lei Qian, Ralph P. Eatough, Baoda Li, Duncan R. Lorimer, Yinfeng Dai, Yaowei Li, Xingnan Zhang, Minghui Li, Tianhao Su, Yuxiao Wu, Yu Pan, Yujie Lian, Tong Liu, Zhen Yan, Zhichen Pan   +16 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Is Earendel a Star Cluster?: Metal-poor Globular Cluster Progenitors at z ∼ 6

The Astrophysical Journal Letters
The strongly lensed z  ∼ 6 Sunrise galaxy offers an incredible opportunity to investigate star formation in the early Universe on parsec or smaller scales.
Massimo Pascale, Liang Dai, Brenda L. Frye, Aliza G. Beverage   +3 more
doaj   +1 more source

Retention fractions for globular cluster neutron stars [PDF]

Monthly Notices of the Royal Astronomical Society, 1996
To appear in MNRAS, 15 pages, LaTeX, requires MN and epsf styles, includes 3 PS Figures, compressed, uuencoded ...
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Hot Stars in Globular Clusters: A Spectroscopist’s View [PDF]

Publications of the Astronomical Society of the Pacific, 2001
Globular clusters are ideal laboratories to study the evolution of low-mass stars. In this work we concentrate on three types of hot stars observed in globular clusters: horizontal branch stars, UV bright stars, and white dwarfs. After providing some historical background and information on gaps and blue tails we discuss extensively hot horizontal ...
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Globular Cluster Counts around 700 Nearby Galaxies

The Astrophysical Journal
Empirically, the total number (or total mass) of globular clusters (GCs) bound in a single galactic system correlates with the virial mass of the system. The form of this relation and its intrinsic scatter are potentially valuable constraints on theories
Minh Ngoc Le, Andrew P. Cooper
doaj   +1 more source