Results 81 to 90 of about 2,554 (268)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Searching for Variability in the Blue Straggler Star Region of the Globular Cluster NGC 6397

The Astronomical Journal
We studied stellar variability in the subgiant branch and blue straggler stars region of the globular cluster NGC 6397. The aim of this research is to identify and characterize new short-period, low-amplitude variable stars.
T. Cisternas-Araya, C. C. Cortés, S. Villanova, J. A. Ahumada, M. C. Parisi   +4 more
doaj   +1 more source

Variable stars in the globular cluster NGC 2419

, 2005
We have used DOLORES at the TNG to obtain B,V time series photometry of NGC 2419, one of the most distant and bright clusters in the Galactic halo. These data will be used to study its variable star population in order to check whether the cluster could be the relic of an extragalactic system accreted by the Milky Way.
Ripepi, V., Greco, C., Baldacci, L., Di Fabrizio, L., Clementini, G., Federici, L., Maio, M., Marconi, M., Musella, I., Stetson, P.   +9 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Ancient Relic Moderately Metal-rich Bulge Cluster Tonantzintla 2

The Astrophysical Journal Letters
The assembly history of the Galactic bulge is intimately tied to the formation of the proto–Milky Way, yet reconstructing this early phase is difficult because mergers and secular evolution have erased most of its original structure.
Sergio Ortolani, Stefano O. Souza, Domenico Nardiello, Beatriz Barbuy, Eduardo Bica, Bernardo P.L. Ferreira, Cristina Chiappini, José G. Fernández-Trincado, Heitor Ernandes   +8 more
doaj   +1 more source

The inner Galactic globular clusters

EPJ Web of Conferences, 2013
Galactic globular clusters located towards the inner regions of the Milky Way have been historically neglected, mainly due to the difficulties caused by the presence of an elevated extinction by foreground dust, and high field star densities along the ...
Mateo M., Catelan M., Alonso-García J., Minniti D.   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Searching for Pulsars in Globular Clusters with the Fast-folding Algorithm and a New Pulsar Discovered in M13

The Astrophysical Journal
We employed the fast-folding algorithm on L -band globular cluster (GC) observations taken with the Five-hundred-meter Aperture Spherical radio Telescope to search for new pulsars, especially those with a long rotational period.
Yaowei Li, Lin Wang, Lei Qian, Liyun Zhang, Yujie Chen, Dejiang Yin, Baoda Li, Yinfeng Dai, Ralph P. Eatough, Wenze Li, Dongyue Jiang, Xingnan Zhang, Minghui Li, Yujie Lian, Yuxiao Wu, Tong Liu, Kuo Liu, Zhichen Pan   +17 more
doaj   +1 more source