Results 81 to 90 of about 2,490 (267)

Globular Cluster Counts around 700 Nearby Galaxies

The Astrophysical Journal
Empirically, the total number (or total mass) of globular clusters (GCs) bound in a single galactic system correlates with the virial mass of the system. The form of this relation and its intrinsic scatter are potentially valuable constraints on theories
Minh Ngoc Le, Andrew P. Cooper
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Searching for Pulsars in Globular Clusters with the Fast-folding Algorithm and a New Pulsar Discovered in M13

The Astrophysical Journal
We employed the fast-folding algorithm on L -band globular cluster (GC) observations taken with the Five-hundred-meter Aperture Spherical radio Telescope to search for new pulsars, especially those with a long rotational period.
Yaowei Li, Lin Wang, Lei Qian, Liyun Zhang, Yujie Chen, Dejiang Yin, Baoda Li, Yinfeng Dai, Ralph P. Eatough, Wenze Li, Dongyue Jiang, Xingnan Zhang, Minghui Li, Yujie Lian, Yuxiao Wu, Tong Liu, Kuo Liu, Zhichen Pan   +17 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Ancient Relic Moderately Metal-rich Bulge Cluster Tonantzintla 2

The Astrophysical Journal Letters
The assembly history of the Galactic bulge is intimately tied to the formation of the proto–Milky Way, yet reconstructing this early phase is difficult because mergers and secular evolution have erased most of its original structure.
Sergio Ortolani, Stefano O. Souza, Domenico Nardiello, Beatriz Barbuy, Eduardo Bica, Bernardo P.L. Ferreira, Cristina Chiappini, José G. Fernández-Trincado, Heitor Ernandes   +8 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Searching for Variability in the Blue Straggler Star Region of the Globular Cluster NGC 6397

The Astronomical Journal
We studied stellar variability in the subgiant branch and blue straggler stars region of the globular cluster NGC 6397. The aim of this research is to identify and characterize new short-period, low-amplitude variable stars.
T. Cisternas-Araya, C. C. Cortés, S. Villanova, J. A. Ahumada, M. C. Parisi   +4 more
doaj   +1 more source

The inner Galactic globular clusters

EPJ Web of Conferences, 2013
Galactic globular clusters located towards the inner regions of the Milky Way have been historically neglected, mainly due to the difficulties caused by the presence of an elevated extinction by foreground dust, and high field star densities along the ...
Mateo M., Catelan M., Alonso-García J., Minniti D.   +3 more
doaj   +1 more source