Results 161 to 170 of about 87,149 (376)
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
PHANGS Hubble Space Telescope Treasury Survey: Globular Cluster Systems in 17 Nearby Spiral Galaxies
The Astronomical JournalWe present new catalogs of likely globular clusters (GCs) in 17 nearby spiral galaxies studied as part of the PHANGS Hubble Space Telescope (HST) Treasury Survey.
Matthew Floyd +20 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
JWST NIRCam Observations of the Globular Cluster Population of RXJ 2129.7+0005
The Astrophysical JournalWe present an analysis of the globular cluster (GC) population in the galaxy cluster RXJ 2129.7+0005 ( z = 0.234) based on JWST NIRCam imaging in three filters: F115W, F150W, and F200W.
Kaitlyn E. Keatley, William E. Harris
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Mass Distribution of Binary Black Hole Mergers from Young and Old Dense Star Clusters
The Astrophysical JournalDense star clusters are thought to contribute significantly to the merger rates of stellar-mass binary black holes (BBHs) detected by the LIGO–Virgo–KAGRA collaboration.
Claire S. Ye +3 more
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Spectroscopic Study of Globular and Fuzzy Clusters in Lenticular Galaxy NGC 1023
The Astrophysical JournalWe here report the results from spectroscopic observations of a sample of 26 globular cluster (GC) and 21 faint fuzzy (FF) candidates in the lenticular galaxy NGC 1023 using the 10.4 m Gran Telescopio Canarias.
M. A. López-Santamaría +7 more
doaj +1 more source