Results 31 to 40 of about 2,490 (267)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

On the disc and halo of the milky way through a study of star clusters [PDF]

Serbian Astronomical Journal, 2000
The subject is the metallicity and the correlation between the metallicity and spatial distribution of star clusters of the Milky Way. The open star clusters are confirmed as good indicators for the population of the galactic disc, whereas the globular ...
Nagl M.
doaj   +1 more source

Rotation of Horizontal‐Branch Stars in Globular Clusters [PDF]

The Astrophysical Journal, 2000
The rotation of horizontal branch stars places important constraints on angular momentum evolution in evolved stars and therefore rotational mixing on the giant branch. Prompted by new observations of rotation rates of horizontal branch stars, we calculate simple models for the angular momentum evolution of a globular cluster giant star from the base ...
Sills, Alison, Pinsonneault, M. H.
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A JWST Project on 47 Tucanae: NIRSpec Spectroscopy of Multiple Populations among M Dwarfs

The Astrophysical Journal Letters
We present the first spectroscopic estimates of the chemical abundance of M dwarf stars in a globular cluster (GC), namely 47 Tucanae. By exploiting NIRSpec on board the James Webb Space Telescope, we gathered low-resolution spectra for 28 stars with ...
A. F. Marino, A. P. Milone, A. Renzini, E. Dondoglio, E. Bortolan, M. G. Carlos, G. Cordoni, A. Dotter, S. Jang, E. P. Lagioia, M. V. Legnardi, F. Muratore, A. Mohandasan, M. Tailo, T. Ziliotto   +14 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Star-crossed Clusters: Asteroseismic Ages for Individual Stars Are in Tension with the Ages of Their Host Clusters

The Astrophysical Journal Letters
A meta-analysis of seismic ages determined for individual stars in the well-studied open and globular clusters NGC 6819, NGC 6791, M67, M4, M19, M80, and M9 reveals both high variance across measurements and a possible discrepancy with independent ...
Jamie Tayar, Meridith Joyce
doaj   +1 more source

r-process Abundance Patterns in the Globular Cluster M92

The Astrophysical Journal, 2023
Whereas light-element abundance variations are a hallmark of globular clusters, there is little evidence for variations in neutron-capture elements. A significant exception is M15, which shows a star-to-star dispersion in neutron-capture abundances of at
Evan N. Kirby, Alexander P. Ji, Mikhail Kovalev   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source