Results 171 to 180 of about 321 (221)

Helical reconstruction of amyloids in cryoSPARC

Acta Crystallographica Section F, EarlyView.
We present practical guidelines for helical reconstruction of amyloid filaments in cryoSPARC, benchmarked against publicly available datasets. Our analysis defines current capabilities and limitations, and outlines optimization strategies to enable high‐throughput structural studies and therapeutic discovery.Amyloid‐mediated proteotoxicity underlies ...
Jan-Hannes Schaefer, Robert T. O'Neill, Joseph P. Donnelly, Evan T. Powers, Jeffery W. Kelly, Gabriel C. Lander   +5 more
wiley   +1 more source

A reappraisal of the Middle to Later Stone Age prehistory of Morocco Réévaluer la préhistoire du Maroc, du Middle Stone Age au Later Stone Age

Journal of the Royal Anthropological Institute, EarlyView.
Over the last 25 years, perceptions of the early prehistory of Northwest Africa have undergone radical changes due to new fieldwork projects and a corresponding growth in scientific interest in the region. Much of this work has been focused in Morocco, known for its extremely rich fossil and archaeological records in caves and rock shelters.
Nick Barton, Abdeljalil Bouzouggar, Stacy Carolin, Louise Humphrey   +3 more
wiley   +1 more source

The morphological affinities of the fossil cranium from Kabua, Kenya Affinités morphologiques du crâne fossile de Kabua (Kenya)

Journal of the Royal Anthropological Institute, EarlyView.
Our current understanding of the origins of Homo sapiens is limited, in part, by the fragmented fossil record from Late Pleistocene and early Holocene Africa. Here, we re‐examine the Kabua 1 cranium, an enigmatic and little‐studied Kenyan fossil discovered in the 1950s. We compare virtual reconstructions created previously by our team with a wide range
Abel Marinus Bosman, Laura Tabitha Buck, Hugo Reyes‐Centeno, Marta Mirazón Lahr, Chris Stringer, Rainer Grün, Qingfeng Shao, Katerina Harvati   +7 more
wiley   +1 more source

Recent progress in studies of the last million years of human physical and behavioural evolution Avancées récentes dans l’étude du dernier million d'années d’évolution physique et éthologique de l'espèce humaine

Journal of the Royal Anthropological Institute, EarlyView.
This article presents a synthesis of recent developments in the study of human evolution over the past five years. It begins with an overview of hominin species nomenclature and diversity, followed by an examination of the proposed population bottleneck ∼900,000 years ago.
James Cole, Eleanor M.L. Scerri, Mateja Hajdinjak, Chris Stringer   +3 more
wiley   +1 more source

New Results From the Pre‐Pottery Neolithic Site of Al Uyaynah, Tabuk, in Northwestern Saudi Arabia

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT Al Uyaynah is a low sandstone mound on an alluvial plain, long known for its extensive surface remains of stone‐built circular and rectangular structures. Following test excavations in 2012, more detailed excavation was undertaken in 2016 within one of the largest rectangular stone structures.
Khalid Alasmari, Stephanie F. Piper, Kirsten Grothe, W. Derek Hamilton, Delphine Joly, Penny Bickle, Geoff Bailey   +6 more
wiley   +1 more source

Between the Indian Ocean and the Gulf: Ceramics From Ḥattā Oasis in the Emirate of Dubai

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT This study presents the ceramic finds from archaeological investigations conducted in 2024 at two settlements: ‘Islamic Village' and Suhaila 2, one of a number of mountain villages of the Late Islamic period within the Ḥattā Oasis: a high‐altitude exclave in the Emirate of Dubai. The sites are located on the northeastern slopes of Jabal Qallāt
Seth M. N. Priestman, Agnese Kukela, Mansour Boraik, Hassan Mohammed Zein   +3 more
wiley   +1 more source

Microarrayed Allergen Molecules Distinguish IgE Sensitisation to Blomia tropicalis and Dermatophagoides pteronyssinus

Allergy, EarlyView.
This study established a microarray containing a representative panel of purified Blo t and Der p allergens for the identification of patients sensitised to Blo t and/or Der p. Results indicate that the microarray based on Blo t and Der p allergens is a useful tool for the identification of Blo t‐ and/or Der p‐sensitised patients. The microarray may be
Nishelle Dsouza, Siratcha Phanthong, Huey‐Jy Huang, Milena Weber, Eszter Sarzsinszky, Petra Zieglmayer, Gabrielle Pauli, Margarete Focke‐Tejkl, Mikhail Tulaev, Nikolina Todorovic, Walter Keller, Thomas Schlederer, Luis Caraballo, Anchalee Tungtrongchitr, Rudolf Valenta, Pongsakorn Tantilipikorn, Susanne Vrtala   +16 more
wiley   +1 more source

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy

Allergy, EarlyView.
DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane, Maria Salas, Sara Benede, Maria J. Rodriguez‐Sanchez, Maria J. Rodriguez‐Sojo, Isabel M. Jiménez‐Sánchez, Gador Bogas, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, Juan L. Paris, Alba Rodríguez‐Nogales, María J. Torres, María I. Montañez   +12 more
wiley   +1 more source

How round is a protein? Exploring protein structures for globularity using conformal mapping

, 2020
Hass, Joel,; Koehl, Patrice,
core  

Neanderthal introgression sheds light on modern human brain globularity

Gunz, P., Wittfeld, K., Manzi, G., Shapland, C., St Pourcain, B., Grabe, H., Tilot, A., Hosten, N., Vernot, B., Kelso, J., Dannemann, M., Brunner, H., Enard, W., Di Vincenzo, F., Guadalupe, T., Franke, B., Macciardi, F., Fisher, S., Fernandez, G., Profico, A., Völker, U., Hublin, J., Teumer, A., Neubauer, S., Pääbo, S., Fallon, J., Van Erp, T.   +26 more
core