Results 1 to 10 of about 359,557 (359)

Absolute binding free energy calculations improve enrichment of actives in virtual compound screening [PDF]

Sci Rep, 2022
We determined the effectiveness of absolute binding free energy (ABFE) calculations to refine the selection of active compounds in virtual compound screening, a setting where the more commonly used relative binding free energy approach is not readily ...
Mudong, Feng, Michael, Gilson, Germano, Heinzelmann   +2 more
core   +2 more sources

A dermis-on-a-chip model for compound screening. [PDF]

Mater Today Bio
Dermal fibrosis is a significant barrier to effective wound healing, with excessive myofibroblast activation and extracellular matrix deposition leading to scar formation and compromised tissue function. Current in vitro models for studying dermal fibrosis, such as monolayer cultures and human skin equivalents (HSEs), have limited physiological ...
Abdo D, Zhao Y, Okhovatian S, Jiménez Vargas LF, Wagner KT, Shakeri A, Vosoughi D, Radisic M.   +7 more
europepmc   +3 more sources

Surface Functionalized Magnetic Nanoparticles as a Selective Sorbent for Affinity Fishing of PPAR-γ Ligands from Choerospondias axillaris

Molecules, 2022
Coronary heart disease (CHD), which has developed into one of the major diseases, was reported to be treated by the target of peroxisome proliferators-activate receptor γ (PPAR-γ).
Miaomiao Chi, Kunming Qin, Lei Cao, Min Zhang, Yingying Su, Xun Gao   +5 more
doaj   +1 more source

VHL-HIF-2α axis-induced SEMA6A upregulation stabilized β-catenin to drive clear cell renal cell carcinoma progression

Cell Death and Disease, 2023
SEMA6A is a multifunctional transmembrane semaphorin protein that participates in various cellular processes, including axon guidance, cell migration, and cancer progression.
Jing Ji, Yuxin Xu, Mengru Xie, Xingbei He, Dexu Ren, Teng Qiu, Wenwen Liu, Zefeng Chen, Wen Shi, Zhen Zhang, Xiujun Wang, Weiling Wang, Jinming Ma, Qilan Qian, Aixin Jing, Xinhui Ma, Jingting Qin, Yuanyuan Ding, Ting Geng, Jiayan Yang, Zhichao Sun, Wei Liu, Shunfang Liu, Bin Liu   +23 more
doaj   +1 more source

Isolation, Purification and Crystallization of Restriction Enzyme Bsa I and Its Preparation of Seleno-derived Derivatives

Shipin gongye ke-ji, 2023
Objective: To screen and optimize the method for preparing three-dimensional structural samples of restriction endonuclease Bsa I. Methods: In this study, the Escherichia coli expression system was employed to express the Bsa I protein and its ...
Hai ZHU, Mengze ZHENG, Weiwei JIA, Qian ZHOU, Shuai TAN, Ziang LIU, Chuanzhi ZHANG, Weiling WANG, Tingting LI   +8 more
doaj   +1 more source

FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development

Cell Death and Disease, 2022
SAD1/UNC84 domain protein-2 (SUN2) plays a tumor suppressor role in various types of cancer by inhibiting cancer cell proliferation, migration and promoting apoptosis.
Jing Ji, Jing Shen, Yuxin Xu, Mengru Xie, Qilan Qian, Teng Qiu, Wen Shi, Dexu Ren, Jinming Ma, Wei Liu, Bin Liu   +10 more
doaj   +1 more source

Synergistic Antinociceptive Effects of Indomethacin–Pregabalin and Meloxicam–Pregabalin in Paclitaxel-Induced Neuropathic Pain

Biomedicines, 2022
Neuropathic pain is often closely associated with nerve injury or inflammation, and the role of traditional nonsteroidal anti-inflammatory drugs as adjuvants for treating chemotherapy-induced peripheral neuropathic pain remains unclear.
Yurong Ma, Wenwen Liu, Lingzhi Liang, Jiaqi Ye, Chaonan Huang, Tao Zhuang, Guisen Zhang   +6 more
doaj   +1 more source

Microwave-Assisted Extraction Coupled with Mass Spectrometry for Determining Five Volatile Compounds from Soy Sauces

Journal of Analytical Methods in Chemistry, 2021
As a popular fermented condiment in oriental countries, soy sauce plays a more and more important role in modern food culture due to its unique smell and delicious taste.
Kai Xu, Xun Gao, Miaomiao Chi, Kexin Chen, Yue Zhang, Weihao Kong, Ziying Li, Shengnan Huang, Kunming Qin   +8 more
doaj   +1 more source

Compounds In Literature (CIL): screening for compounds and relatives in PubMed [PDF]

Bioinformatics, 2011
Abstract Summary: Searching for certain compounds in literature can be an elaborate task, with many compounds having several different synonyms. Often, only the structure is known but not its name. Furthermore, rarely investigated compounds may not be described in the available literature at all.
Björn A. Grüning, Christian Senger, Anika Erxleben, Stephan Flemming, Stefan Günther   +4 more
openaire   +3 more sources

Aeromonas sobria Induces Proinflammatory Cytokines Production in Mouse Macrophages via Activating NLRP3 Inflammasome Signaling Pathways

Frontiers in Cellular and Infection Microbiology, 2021
Aeromonas sobria, a common conditional pathogenic bacteria, is widely distributed in the environment and causes gastroenteritis in humans or septicemia in fish. Of all Aeromonas species, A.
Wei Zhang, Zhixing Li, Haitao Yang, Guanglu Wang, Gang Liu, Yu Wang, Babatunde Kazeem Bello, Panpan Zhao, Wei Liang, Jingquan Dong   +9 more
doaj   +1 more source