Results 11 to 20 of about 690,492 (301)

Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni [PDF]

, 2015
Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple ...
Altamura, Sergio, Bresciani, Alberto, Gennari, Nadia, GUIDI, ALESSANDRA, LALLI, CRISTIANA, Ruberti, Giovina   +5 more
core   +3 more sources

Vibrio alginolyticus Triggers Inflammatory Response in Mouse Peritoneal Macrophages via Activation of NLRP3 Inflammasome

Frontiers in Cellular and Infection Microbiology, 2021
Vibrio alginolyticus is a food-borne marine Vibrio that causes gastroenteritis, otitis media, otitis externa, and septicemia in humans. The pathogenic mechanisms of V.
Jinxin Wang, Qun Ding, Qiankun Yang, Hui Fan, Guili Yu, Feixue Liu, Babatunde Kazeem Bello, Xiao Zhang, Tianmeng Zhang, Jingquan Dong, Gang Liu, Panpan Zhao   +11 more
doaj   +1 more source

A novel FRET-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters [PDF]

, 2016
The glucose transporter PfHT is essential to the survival of the malaria parasite Plasmodium falciparum and has been shown to be a druggable target with high potential for pharmacological intervention.
Autry, Joseph M, Edwards, Rachel L, Heitmeier, Monique R, Hruz, Paul W, Ilagan, Ma Xenia G, Kraft, Thomas E, Odom, Audrey R, Payne, Maria A, Putanko, Marina, Thomas, David D   +9 more
core   +2 more sources

Screening for bioactive compounds from algae [PDF]

Journal of Pharmaceutical and Biomedical Analysis, 2010
In the present work, a comprehensive methodology to carry out the screening for novel natural functional compounds is presented. To do that, a new strategy has been developed including the use of unexplored natural sources (i.e., algae and microalgae) together with environmentally clean extraction techniques and advanced analytical tools. The developed
Plaza, Merichel, Santoyo, Susana, Jaime, Laura, García-Blairsy Reina, G., Herrero, Miguel, Señoráns, Francisco J., Ibáñez, Elena   +6 more
openaire   +4 more sources

Rapid and accurate genotyping of human SNP rs671 in aldehyde dehydrogenase 2 gene using one-step CRISPR/Cas12b assay without DNA amplification

Cell Division, 2023
Background The SNP rs671 of Human aldehyde dehydrogenase (ALDH) is G-A transition at 1510th nucleotides, which is an important clinical indicator of alcoholic liver disease, digestive tract cancer and some drug efficiency.
Fang Wu, Yong Xue, Yan Wang, Xinxin Si, Xinyue Zhang, Yuyang Xu, Zhidan Luo   +6 more
doaj   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio, Alvarez, Emilio, Bardera, Ana I., Barroso, Vanessa, Brown, James R., Cantizani, Juan, Colmenarejo, Gonzalo, Cotillo, Ignacio, de Dios-Anton, Francisco, Drewry, David H., Fiandor, Jose M., Gray, David W., Julio Martin, J., Kessler, Albane, Kumar, Vinod, Navarro, Miguel, Peña, Imanol, Pilar Manzano, M., Rodriguez, Ana, Roquero, Irene, Sherstnev, Alexander   +20 more
core   +3 more sources

Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. [PDF]

, 2018
Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays.
Duggan, Brendan M, Emwas, Abdul-Hamid, Gerwick, William H, Kharbatia, Najeh, Kremb, Stephan, O'Rourke, Aubrie, Raji, Misjudeen, Sioud, Salim, Voolstra, Christian R   +8 more
core   +3 more sources

Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression

Cancer Cell International, 2021
Background Hepatocellular carcinoma (HCC) is the third cause of cancer death in the world, and few molecularly targeted anticancer therapies have been developed to treat it. The E3 ubiquitin ligase RNF152 has been reported to regulate the activity of the
Jian Wan, Shunfang Liu, Wanju Sun, Haiyi Yu, Wenlian Tang, Wei Liu, Jing Ji, Bin Liu   +7 more
doaj   +1 more source

Magnetic Ligand Fishing Using Immobilized Cyclooxygenase-2 for Identification and Screening of Anticoronary Heart Disease Ligands From Choerospondias axillaris

Frontiers in Nutrition, 2022
Inhibition of cyclooxygenase-2 (COX-2) activity is an effective way for treatment of coronary heart disease. And as an important source of COX-2 inhibitors, bioactive compounds of Choerospondias axillaris and pharmacological mechanisms remained lacking ...
Miaomiao Chi, Hongsen Wang, Zhankuan Yan, Lei Cao, Xun Gao, Xun Gao, Xun Gao, Kunming Qin   +7 more
doaj   +1 more source

Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate

Pharmaceutics, 2021
Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions.
Chenxin Duan, Wenwen Liu, Yunwen Tao, Feifei Liang, Yanming Chen, Xinyi Xiao, Guisen Zhang, Yin Chen, Chao Hao   +8 more
doaj   +1 more source