Results 11 to 20 of about 328,812 (261)

Isolation and Characterization of an Unknown Process-Related Impurity in Furosemide and Validation of a New HPLC Method

Molecules, 2023
Furosemide is a widely used loop diuretic in the treatment of congestive heart failure and edema. During the preparation of furosemide, a new process-related impurity G in the levels ranging from 0.08% to 0.13% was detected in pilot batches by a new high
Ao Xu, Yunlin Xue, Yuyu Zeng, Jing Li, Huiling Zhou, Zhen Wang, Yin Chen, Hui Chen, Jian Jin, Tao Zhuang   +9 more
doaj   +1 more source

Determination of four parabens in cosmetics by high-performance liquid chromatography with magnetic solid-phase and ionic dispersive liquid–liquid extraction

Reviews in Analytical Chemistry, 2021
To determine the trace amount of four benzoic acid esters in cosmetics, ionic dispersive liquid–liquid microextraction (DLLME) and magnetic solid-phase extraction were combined and optimized.
Gao Xun, Xu Kai, Chi Miaomiao, Li Jiaojiao, Suo Lingzhe, Zhu Lin, Chen Kexin, Mu Jingqing   +7 more
doaj   +1 more source

Stability of Screening Compounds in Wet DMSO [PDF]

SLAS Discovery, 2008
The impact of storage conditions on compound stability and compound solubility has been debated intensely over the past 5 years. At Novartis, the authors decided to opt for a storage concept that can be considered controversial because they are using a DMSO/water (90/10) mixture as standard solvent.
Caroline, Engeloch, Ulrich, Schopfer, Ingo, Muckenschnabel, Francois, Le Goff, Hervé, Mees, Karoline, Boesch, Maxim, Popov   +6 more
openaire   +2 more sources

Vibrio alginolyticus Triggers Inflammatory Response in Mouse Peritoneal Macrophages via Activation of NLRP3 Inflammasome

Frontiers in Cellular and Infection Microbiology, 2021
Vibrio alginolyticus is a food-borne marine Vibrio that causes gastroenteritis, otitis media, otitis externa, and septicemia in humans. The pathogenic mechanisms of V.
Jinxin Wang, Qun Ding, Qiankun Yang, Hui Fan, Guili Yu, Feixue Liu, Babatunde Kazeem Bello, Xiao Zhang, Tianmeng Zhang, Jingquan Dong, Gang Liu, Panpan Zhao   +11 more
doaj   +1 more source

Rapid and accurate genotyping of human SNP rs671 in aldehyde dehydrogenase 2 gene using one-step CRISPR/Cas12b assay without DNA amplification

Cell Division, 2023
Background The SNP rs671 of Human aldehyde dehydrogenase (ALDH) is G-A transition at 1510th nucleotides, which is an important clinical indicator of alcoholic liver disease, digestive tract cancer and some drug efficiency.
Fang Wu, Yong Xue, Yan Wang, Xinxin Si, Xinyue Zhang, Yuyang Xu, Zhidan Luo   +6 more
doaj   +1 more source

Screening for bioactive compounds from algae [PDF]

Journal of Pharmaceutical and Biomedical Analysis, 2010
In the present work, a comprehensive methodology to carry out the screening for novel natural functional compounds is presented. To do that, a new strategy has been developed including the use of unexplored natural sources (i.e., algae and microalgae) together with environmentally clean extraction techniques and advanced analytical tools. The developed
Plaza, Merichel, Santoyo, Susana, Jaime, Laura, García-Blairsy Reina, G., Herrero, Miguel, Señoráns, Francisco J., Ibáñez, Elena   +6 more
openaire   +4 more sources

Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression

Cancer Cell International, 2021
Background Hepatocellular carcinoma (HCC) is the third cause of cancer death in the world, and few molecularly targeted anticancer therapies have been developed to treat it. The E3 ubiquitin ligase RNF152 has been reported to regulate the activity of the
Jian Wan, Shunfang Liu, Wanju Sun, Haiyi Yu, Wenlian Tang, Wei Liu, Jing Ji, Bin Liu   +7 more
doaj   +1 more source

Magnetic Ligand Fishing Using Immobilized Cyclooxygenase-2 for Identification and Screening of Anticoronary Heart Disease Ligands From Choerospondias axillaris

Frontiers in Nutrition, 2022
Inhibition of cyclooxygenase-2 (COX-2) activity is an effective way for treatment of coronary heart disease. And as an important source of COX-2 inhibitors, bioactive compounds of Choerospondias axillaris and pharmacological mechanisms remained lacking ...
Miaomiao Chi, Hongsen Wang, Zhankuan Yan, Lei Cao, Xun Gao, Xun Gao, Xun Gao, Kunming Qin   +7 more
doaj   +1 more source

Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate

Pharmaceutics, 2021
Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions.
Chenxin Duan, Wenwen Liu, Yunwen Tao, Feifei Liang, Yanming Chen, Xinyi Xiao, Guisen Zhang, Yin Chen, Chao Hao   +8 more
doaj   +1 more source

Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells

Cancer Cell International, 2021
Background Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life.
Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu, Mingzhi Zhang   +5 more
doaj   +1 more source