Results 21 to 30 of about 359,557 (359)

Screening for bioactive compounds from algae [PDF]

Journal of Pharmaceutical and Biomedical Analysis, 2010
In the present work, a comprehensive methodology to carry out the screening for novel natural functional compounds is presented. To do that, a new strategy has been developed including the use of unexplored natural sources (i.e., algae and microalgae) together with environmentally clean extraction techniques and advanced analytical tools. The developed
Plaza, Merichel, Santoyo, Susana, Jaime, Laura, García-Blairsy Reina, G., Herrero, Miguel, Señoráns, Francisco J., Ibáñez, Elena   +6 more
openaire   +4 more sources

Volatile compound fingerprinting of mixed-culture fermentations. [PDF]

, 2011
Item does not contain fulltextWith the advent of the -omics era, classical technology platforms, such as hyphenated mass spectrometry, are currently undergoing a transformation toward high-throughput application.
Hylckama, J., van, Sieuwerts, S., Molenaar, D, Arjen Lommen, Bayjanov, J.R., Molenaar, D., van Hylckama, J., Molenaar, D.; id_orcid, Janssen, P.W.M., Bok, F.A. de, van Hylckama Vlieg, J.E.T., Patrick W. M. Janssen, Douwe Molenaar, Jumamurat R. Bayjanov, Bayjanov, J., Johan E. T. van Hylckama Vlieg, Sander Sieuwerts, Hylckama Vlieg, J.E.T. van, de Bok, F.A.M., Lommen, A., Bok, F.A.M., de, Bok, F.A.M. de, Janssen, P.W., Frank A. M. de Bok, Hylckama Vlieg, J.E. van   +24 more
core   +1 more source

Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression

Cancer Cell International, 2021
Background Hepatocellular carcinoma (HCC) is the third cause of cancer death in the world, and few molecularly targeted anticancer therapies have been developed to treat it. The E3 ubiquitin ligase RNF152 has been reported to regulate the activity of the
Jian Wan, Shunfang Liu, Wanju Sun, Haiyi Yu, Wenlian Tang, Wei Liu, Jing Ji, Bin Liu   +7 more
doaj   +1 more source

Magnetic Ligand Fishing Using Immobilized Cyclooxygenase-2 for Identification and Screening of Anticoronary Heart Disease Ligands From Choerospondias axillaris

Frontiers in Nutrition, 2022
Inhibition of cyclooxygenase-2 (COX-2) activity is an effective way for treatment of coronary heart disease. And as an important source of COX-2 inhibitors, bioactive compounds of Choerospondias axillaris and pharmacological mechanisms remained lacking ...
Miaomiao Chi, Hongsen Wang, Zhankuan Yan, Lei Cao, Xun Gao, Xun Gao, Xun Gao, Kunming Qin   +7 more
doaj   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +1 more source

Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate

Pharmaceutics, 2021
Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions.
Chenxin Duan, Wenwen Liu, Yunwen Tao, Feifei Liang, Yanming Chen, Xinyi Xiao, Guisen Zhang, Yin Chen, Chao Hao   +8 more
doaj   +1 more source

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target [PDF]

, 2014
The human pathogen Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis (TB), a disease with high worldwide mortality rates. Current treatment programs are under significant threat from multi-drug and extensively-drug resistant ...
VijayaShankar Nataraj, Reynolds Robert C., Nicholas J Loman, Lloyd, AJ, Besra, Gurdyal S., Klaus Fütterer, Ballell, L, Reynolds, Robert C., Abrahams, Katherine A, Loman, Nicholas J., Hobrath Judith V., Gurcha Sudagar S., Alderwick, LJ, Abrahams, Katherine A., Gurcha, SS, Cox, Jonathan A G, Abrahams Katherine A., Hobrath, JV, Loman, Nicholas J, Carlos Alemparte, Lluis Ballell, Bhatt, Apoorva; id_orcid, Cox Jonathan A. G., Loman, NJ, Besra, GS, Reynolds, Robert C, Alemparte Carlos, Alderwick, Luke J, Gurcha, Sudagar S, Besra, Gurdyal S; id_orcid, Abrahams, KA, Besra Gurdyal S., Hobrath, Judith V, Barros, D, Robert C Reynolds, Loman Nicholas J., Bhatt, A, Ballell, Lluis, Nataraj, VijayaShankar, Lloyd, Adrian J., Apoorva Bhatt, Bhatt Apoorva, Nataraj, V, Alemparte, Carlos, Lloyd, Adrian J, Fütterer, K, Hobrath, Judith V., Veeraraghavan Usha, Cox, Jonathan A. G., Cox, JA, Barros David, Veeraraghavan, Usha, Bhatt, Apoorva, Adrian J Lloyd, Jonathan A G Cox, Usha, V, Gurdyal S Besra, David Barros, Lloyd Adrian J., Reynolds, RC, Alderwick, Luke J., Ballell Lluis, Usha Veeraraghavan, Fütterer Klaus, Barros, David, Nataraj, Vijaya-Shankar, Luke J Alderwick, Gurcha, Sudagar S., Alderwick Luke J., Judith V Hobrath, Sudagar S Gurcha, Usha, Veeraraghavan, Nataraj VijayaShankar, Alemparte, C, Fütterer, Klaus, Katherine A Abrahams   +75 more
core   +1 more source

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei. [PDF]

, 2014
In the bloodstream of mammalian hosts, the sleeping sickness parasite, Trypanosoma brucei, exists as a proliferative slender form or a nonproliferative, transmissible, stumpy form.
Auer, Manfred, Ivens, A, Matthews, KR, Matthews, Keith R., Collie, I, Ivens, Alasdair, Auer, M, Gray, David, McGregor, Paula, Macgregor, Paula, Matthews, Keith R; id_orcid, Gray, David; id_orcid, Collie, Iain, Shave, S, MacGregor, P, Gray, D, Shave, Steven   +16 more
core   +1 more source

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source

Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells

Cancer Cell International, 2021
Background Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life.
Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu, Mingzhi Zhang   +5 more
doaj   +1 more source