Results 21 to 30 of about 328,812 (261)

Evaluation of a Screening System for Obesogenic Compounds: Screening of Endocrine Disrupting Compounds and Evaluation of the PPAR Dependency of the Effect [PDF]

PLoS ONE, 2013
Recently the environmental obesogen hypothesis has been formulated, proposing a role for endocrine disrupting compounds (EDCs) in the development of obesity. To evaluate this hypothesis, a screening system for obesogenic compounds is urgently needed. In this study, we suggest a standardised protocol for obesogen screening based on the 3T3-L1 cell line,
Pereira-Fernandes, Anna, Demaegdt, Heidi, Vandermeiren, Karine, Hectors, Tine L.M., Jorens, Philippe G., Blust, Ronny, Vanparys, Caroline   +6 more
openaire   +4 more sources

HIF1A-dependent overexpression of MTFP1 promotes lung squamous cell carcinoma development by activating the glycolysis pathway

Heliyon
Introduction: Mitochondrial fission process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein implicated in the development and progression of various tumors, particularly lung squamous cell carcinoma (LUSC).
Jing Ji, Yasong Wang, Aixin Jing, Ling Ma, Jiayan Yang, Dexu Ren, Jinyu Lv, Mingxiao Lv, Menghan Xu, Qing Yuan, Xinhui Ma, Qilan Qian, Weiling Wang, Ting Geng, Yuanyuan Ding, Jingting Qin, Yuanyuan Liu, Jiaojiao Zhou, Lingyi Zuo, Shaojie Ma, Xiujun Wang, Bin Liu   +21 more
doaj   +1 more source

Rapid On-Site Detection Method for White Spot Syndrome Virus Using Recombinase Polymerase Amplification Combined With Lateral Flow Test Strip Technology

Frontiers in Cellular and Infection Microbiology, 2022
The white spot syndrome virus is the most destructive virus threatening the shrimp industry worldwide, causing hundreds of millions of dollars in economic losses each year. There is currently no specific medicine to treat it.
Tianmeng Zhang, Xia Liu, Xiaohan Yang, Feixue Liu, Haitao Yang, Xueqing Li, Huimiao Feng, Xinyu Wu, Ge Jiang, Hui Shen, Jingquan Dong   +10 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development

Cell Death and Disease
Ovarian cancer (OV) poses a significant challenge in clinical settings due to its difficulty in early diagnosis and treatment resistance. FOXP4, belonging to the FOXP subfamily, plays a pivotal role in various biological processes including cancer, cell ...
Jing Ji, Qilan Qian, Wenhao Cheng, Xiaoqing Ye, Aixin Jing, Shaojie Ma, Yuanyuan Ding, Xinhui Ma, Yasong Wang, Qian Sun, Xiujun Wang, Yulu Chen, Lan Zhu, Qing Yuan, Menghan Xu, Jingting Qin, Lin Ma, Jiayan Yang, Meiqi Zhang, Ting Geng, Sen Wang, Dan Wang, Yizhuo Song, Boyu Zhang, Yuting Xu, Linyu Xu, Shunfang Liu, Wei Liu, Bin Liu   +28 more
doaj   +1 more source

Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

Frontiers in Pharmacology, 2020
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a ...
Jessica D. Panes, Pamela A. Godoy, Tiare Silva-Grecchi, María T. Celis, Oscar Ramirez-Molina, Javiera Gavilan, Carola Muñoz-Montecino, Patricio A. Castro, Gustavo Moraga-Cid, Gonzalo E. Yévenes, Leonardo Guzmán, Jeffrey L. Salisbury, Eugenia Trushina, Jorge Fuentealba, Jorge Fuentealba   +14 more
doaj   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

A Rapid and Sensitive Detection Method for Pseudomonas aeruginosa Using Visualized Recombinase Polymerase Amplification and Lateral Flow Strip Technology

Frontiers in Cellular and Infection Microbiology, 2021
Pseudomonas aeruginosa is a common opportunistic pathogen that causes acute nosocomial necrotizing pneumonia and is the predominant source of chronic lung infections in patients with the genetic disorder cystic fibrosis.
Haitao Yang, Yan Wang, Qiankun Yang, Hui Fan, Lei Wang, Lei Wang, Tianmeng Zhang, Zhixing Li, Gang Liu, Panpan Zhao, Panpan Zhao, Huahua Wu, Jingquan Dong, Wei Liang   +13 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Rapid Detection of Enterocytozoon hepatopenaei Infection in Shrimp With a Real-Time Isothermal Recombinase Polymerase Amplification Assay

Frontiers in Cellular and Infection Microbiology, 2021
Enterocytozoon hepatopenaei (EHP) infection has become a significant threat in shrimp farming industry in recent years, causing major economic losses in Asian countries.
Chao Ma, Shihui Fan, Yu Wang, Haitao Yang, Yi Qiao, Ge Jiang, Mingsheng Lyu, Jingquan Dong, Hui Shen, Song Gao   +9 more
doaj   +1 more source