Results 21 to 30 of about 690,492 (301)

Plate-based diversity subset screening generation 2: An improved paradigm for high throughput screening of large compound files [PDF]

, 2016
High throughput screening (HTS) is an effective method for lead and probe discovery that is widely used in industry and academia to identify novel chemical matter and to initiate the drug discovery process.
A Larsson, A Mullard, A Mullard, AJ Leo, AL Harvey, Andrew S. Bell, AS Bell, CA Lipinski, Christine Williams, D Joseph-McCarthy, D Patel, D Seeliger, D Stumpfe, DA Pereira, DA Price, David McLoughlin, DH Drewry, E Gregori-Puigjané, E Kwong, F Pammolli, F Sams-Dodd, FA Zoller, G Schneider, GA Bakken, GM Keserue, H Xi, H Zhu, Hongyao Zhu, J Blagg, J Everett, JA Arnott, James Mills, Jens Loesel, Jeremy R. Everett, JG Cumming, JL LaMattina, Joseph Bradley, JP Hughes, JW Scannell, L Zhang, LM Mayr, Marie-Claire Peakman, MD Breyer, MH Beresini, MP Gleeson, NA Meanwell, P Soulard, PM Petrone, RC Braga, RJ Hall, Robert E. Sharp, RS Pearlman, SC Sukuru, SK Yeap, SM Paul, T Zhu, TA Leil, TH Grasela, TJ Crisman, VJ Gillet, WP Janzen, Y Wang   +61 more
core   +1 more source

Multi-Behavioral Endpoint Testing Of An 87-Chemical Compound Library In Freshwater Planarians [PDF]

, 2018
There is an increased recognition in the field of toxicology of the value of medium-to-high-throughput screening methods using in vitro and alternative animal models.
Collins, Eva-Maria S., Graham, A., Hagstrom, D., Hayes, P., Zhang, S.   +4 more
core   +3 more sources

Positive Vibrational Entropy of Chemical Ordering in FeV [PDF]

, 2011
Inelastic neutron scattering and nuclear resonant inelastic x-ray scattering were used to measure phonon spectra of FeV as a B2 ordered compound and as a bcc solid solution.
Abernathy, D. L., Chow, Paul, Delaire, O., Fultz, B., Li, Chen W., Lucas, M. S., Mauger, L., Muñoz, J. A., Sheets, A. O., Stone, M. B., Winterrose, M. L., Xiao, Yuming   +11 more
core   +1 more source

Artificial environments for the co-translational stabilization of cell-free expressed proteins [PDF]

, 2013
An approach for designing individual expression environments that reduce or prevent protein aggregation and precipitation is described. Inefficient folding of difficult proteins in unfavorable translation environments can cause significant losses of ...
Bernhard, Frank, Dötsch, Volker, Kaldenhoff, Ralf, Lei, Kai   +3 more
core   +7 more sources

Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells

Cancer Cell International, 2021
Background Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life.
Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu, Mingzhi Zhang   +5 more
doaj   +1 more source

Satellites and large doping- and temperature-dependence of electronic properties in hole-doped BaFe2As2 [PDF]

, 2011
Over the last years, superconductivity has been discovered in several families of iron-based compounds. Despite intense research, even basic electronic properties of these materials, such as Fermi surfaces, effective electron masses, or orbital ...
A Georges, A Koitzsch, A Kutepov, AF Albuquerque, AI Lichtenstein, Andrew J. Millis, AS Sefat, B Mansart, C Liu, DJ Singh, F Aryasetiawan, Ferdi Aryasetiawan, H Ding, H Ding, H Ishida, H-H Wen, J Fink, JH Shim, K Haule, K Kuroki, M Aichhorn, M Aichhorn, M Casula, M Rotter, M Yi, Michele Casula, OK Andersen, P Popovich, P Werner, P Werner, P Werner, P Werner, Philipp Werner, PM Alireza, Q Si, S Biermann, S de Jong, S Onari, SAJ Kimber, Silke Biermann, SL Skornyakov, T Miyake, T Sato, Takashi Miyake, V Brouet, VI Anisimov, Y Kamihara, Y Zhang, ZP Yin   +48 more
core   +4 more sources

Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening [PDF]

, 2016
Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of
Babar, Mustafeez Mujtaba, Inayathullah, Mohammed, Kim, K. M., Parekh, Mansi B., Pothineni, Venkata Raveendra, Rajadas, Jayakumar, Samineni, A. V., Solow-Cordero, David, Tayebi, Lobat, Wagh, Dhananjay   +9 more
core   +3 more sources

HIF1A-dependent overexpression of MTFP1 promotes lung squamous cell carcinoma development by activating the glycolysis pathway

Heliyon
Introduction: Mitochondrial fission process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein implicated in the development and progression of various tumors, particularly lung squamous cell carcinoma (LUSC).
Jing Ji, Yasong Wang, Aixin Jing, Ling Ma, Jiayan Yang, Dexu Ren, Jinyu Lv, Mingxiao Lv, Menghan Xu, Qing Yuan, Xinhui Ma, Qilan Qian, Weiling Wang, Ting Geng, Yuanyuan Ding, Jingting Qin, Yuanyuan Liu, Jiaojiao Zhou, Lingyi Zuo, Shaojie Ma, Xiujun Wang, Bin Liu   +21 more
doaj   +1 more source

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]

, 2013
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William, Cuda, F., Eccles, Suzanne A., Fox, Keith R., Hoakwie, Franciane, Lawrence, Charlotte, Male, Abigail, Miranda, Elena, Nordgren, Ida, Packham, Graham K., Tavassoli, Ali, Townsend, Paul   +11 more
core   +1 more source

Rapid On-Site Detection Method for White Spot Syndrome Virus Using Recombinase Polymerase Amplification Combined With Lateral Flow Test Strip Technology

Frontiers in Cellular and Infection Microbiology, 2022
The white spot syndrome virus is the most destructive virus threatening the shrimp industry worldwide, causing hundreds of millions of dollars in economic losses each year. There is currently no specific medicine to treat it.
Tianmeng Zhang, Xia Liu, Xiaohan Yang, Feixue Liu, Haitao Yang, Xueqing Li, Huimiao Feng, Xinyu Wu, Ge Jiang, Hui Shen, Jingquan Dong   +10 more
doaj   +1 more source