Results 31 to 40 of about 359,557 (359)

Spherical harmonics coeffcients for ligand-based virtual screening of cyclooxygenase inhibitors

, 2011
Background: Molecular descriptors are essential for many applications in computational chemistry, such as ligand-based similarity searching. Spherical harmonics have previously been suggested as comprehensive descriptors of molecular structure and ...
Angioni, Carlo, Tim Geppert, Schneider, Petra, Gisbert Schneider, Wang, Quan, Matthias Rupp, Kerstin Birod, Birod, Kerstin, Schneider Petra, Quan Wang, Birod Kerstin, Schneider, Gisbert, Petra Schneider, Rupp, Matthias, Wang Quan, Angioni Carlo, Rupp Matthias, Geppert, Tim, Angioni, Carlo Federico, Geppert Tim, Grösch Sabine, Grösch, Sabine, Carlo Angioni, Schneider, Gisbert (Prof. Dr.), Sabine Grösch, Schneider Gisbert   +25 more
core   +1 more source

medford-group/Screening-Metal-Compound-Active-Sites-N2-Adsorption: Paper submission

, 2023
First submission of ...
AJ Medford
core   +1 more source

Evaluation of a Screening System for Obesogenic Compounds: Screening of Endocrine Disrupting Compounds and Evaluation of the PPAR Dependency of the Effect [PDF]

PLoS ONE, 2013
Recently the environmental obesogen hypothesis has been formulated, proposing a role for endocrine disrupting compounds (EDCs) in the development of obesity. To evaluate this hypothesis, a screening system for obesogenic compounds is urgently needed. In this study, we suggest a standardised protocol for obesogen screening based on the 3T3-L1 cell line,
Pereira-Fernandes, Anna, Demaegdt, Heidi, Vandermeiren, Karine, Hectors, Tine L.M., Jorens, Philippe G., Blust, Ronny, Vanparys, Caroline   +6 more
openaire   +4 more sources

HIF1A-dependent overexpression of MTFP1 promotes lung squamous cell carcinoma development by activating the glycolysis pathway

Heliyon
Introduction: Mitochondrial fission process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein implicated in the development and progression of various tumors, particularly lung squamous cell carcinoma (LUSC).
Jing Ji, Yasong Wang, Aixin Jing, Ling Ma, Jiayan Yang, Dexu Ren, Jinyu Lv, Mingxiao Lv, Menghan Xu, Qing Yuan, Xinhui Ma, Qilan Qian, Weiling Wang, Ting Geng, Yuanyuan Ding, Jingting Qin, Yuanyuan Liu, Jiaojiao Zhou, Lingyi Zuo, Shaojie Ma, Xiujun Wang, Bin Liu   +21 more
doaj   +1 more source

Microfluidic Technologies for High-Throughput Screening Applications [PDF]

, 2003
In this thesis, I present a strategy for the design and development of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed in prokaryotic hosts, where a few point mutations at the DNA level ...
Thorsen, Todd Addison
core   +1 more source

Targeting Quorum Sensing : High-Throughput Screening to Identify Novel LsrK Inhibitors [PDF]

, 2019
Since quorum sensing (QS) is linked to the establishment of bacterial infection, its inactivation represents one of the newest strategies to fight bacterial pathogens.
Tammela, Päivi, Alison Porter, Polina Ilina, Stuart McElroy, McElroy, Stuart, Päivi Tammela, Gatta, Viviana, Ilina, Polina, Viviana Gatta, Porter, Alison   +9 more
core   +1 more source

Rapid On-Site Detection Method for White Spot Syndrome Virus Using Recombinase Polymerase Amplification Combined With Lateral Flow Test Strip Technology

Frontiers in Cellular and Infection Microbiology, 2022
The white spot syndrome virus is the most destructive virus threatening the shrimp industry worldwide, causing hundreds of millions of dollars in economic losses each year. There is currently no specific medicine to treat it.
Tianmeng Zhang, Xia Liu, Xiaohan Yang, Feixue Liu, Haitao Yang, Xueqing Li, Huimiao Feng, Xinyu Wu, Ge Jiang, Hui Shen, Jingquan Dong   +10 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development

Cell Death and Disease
Ovarian cancer (OV) poses a significant challenge in clinical settings due to its difficulty in early diagnosis and treatment resistance. FOXP4, belonging to the FOXP subfamily, plays a pivotal role in various biological processes including cancer, cell ...
Jing Ji, Qilan Qian, Wenhao Cheng, Xiaoqing Ye, Aixin Jing, Shaojie Ma, Yuanyuan Ding, Xinhui Ma, Yasong Wang, Qian Sun, Xiujun Wang, Yulu Chen, Lan Zhu, Qing Yuan, Menghan Xu, Jingting Qin, Lin Ma, Jiayan Yang, Meiqi Zhang, Ting Geng, Sen Wang, Dan Wang, Yizhuo Song, Boyu Zhang, Yuting Xu, Linyu Xu, Shunfang Liu, Wei Liu, Bin Liu   +28 more
doaj   +1 more source

Changes in PGC‐1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

Frontiers in Pharmacology, 2020
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a ...
Jessica D. Panes, Pamela A. Godoy, Tiare Silva-Grecchi, María T. Celis, Oscar Ramirez-Molina, Javiera Gavilan, Carola Muñoz-Montecino, Patricio A. Castro, Gustavo Moraga-Cid, Gonzalo E. Yévenes, Leonardo Guzmán, Jeffrey L. Salisbury, Eugenia Trushina, Jorge Fuentealba, Jorge Fuentealba   +14 more
doaj   +1 more source