Results 51 to 60 of about 359,557 (359)

SPIN-guided engineering of a novel (R)-amine transaminase from Fusarium albosuccineum for enantioselective synthesis of chiral piperidyl amines

Synthetic and Systems Biotechnology
Aminotransferases are promising green biocatalysts for the synthesis of chiral amines, yet their limited catalytic efficiencies restrict broader industrial applications.
Ruizhou Tang, Jiahuan Li, Xiaole Yang, Xia Tian, Zehui Wang, Xuning Zhang, Tingting Li   +6 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Identification of MORF4L1 as an endogenous substrate of CRBN and its potential role as a therapeutic target in cancer

Scientific Reports
The ubiquitin-proteasome system (UPS) is essential for cellular homeostasis, regulating the degradation of proteins involved in key processes such as cell cycle, apoptosis, and DNA repair.
Luyao Zhang, Shunfang Liu, Jingliang He, Zhongke Hu, Lan Zhu, Hongyi Huang, Qi Gao, Dan Wang, Lu Chen, Xingyu Zhang, Ruotong Liu, Jiayun Wang, Yizhuo Song, Kaile Zeng, Xiuming Li, Yulu Chen, Xun Zou, Shaojie Ma, Xiujun Wang, Guofeng Xu, Wei Liu, Bin Liu   +21 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

AlphaFold-Guided Semi-Rational Engineering of an (R)-Amine Transaminase for Green Synthesis of Chiral Amines

Biomolecules
Chiral amines are vital structural motifs in pharmaceuticals and agrochemicals, where enantiomeric purity governs bioactivity and environmental behavior. We identified a novel (R)-selective amine transaminase (MwoAT) from Mycobacterium sp.
Xiaole Yang, Xia Tian, Ruizhou Tang, Jiahuan Li, Xuning Zhang, Tingting Li   +5 more
doaj   +1 more source

Immune Protective Evaluation Elicited by DNA Vaccination With Neospora caninum Dense Granules Proteins in Mice

Frontiers in Veterinary Science, 2021
Neospora caninum, an obligate intracellular protozoan, is the major cause for neosporosis and brings serious economic losses to cattle breeding industries worldwide.
Guili Yu, Wei Liang, Qiankun Yang, Jinxin Wang, Yu Wang, Tianmeng Zhang, Xiao Zhang, Hui Fan, Panpan Zhao, Panpan Zhao, Lili Cao, Lili Cao, Jingquan Dong   +12 more
doaj   +1 more source

Inhibitors of Helicobacter pylori protease HtrA found by "virtual ligand" screening combat bacterial invasion of epithelia

, 2011
Background: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention.
Löwer, Martin, Schneider, Gisbert, Petra Schneider, Hoy Benjamin, Löwer Martin, Martin Löwer, Tim Geppert, Geppert, Tim, Silja Wessler, Wessler Silja, Schneider, Petra, Geppert Tim, Gisbert Schneider, Benjamin Hoy, Hoy, Benjamin, Weßler, Silja, Schneider Petra, Schneider, Gisbert (Prof. Dr.), Schneider Gisbert   +18 more
core   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression

Cell Death and Disease
Endoplasmic reticulum (ER) stress induces the unfolded protein response (UPR), and prolonged ER stress leads to cell apoptosis. Despite increasing research in this area, the underlying molecular mechanisms remain unclear. Here, we discover that ER stress
Jing Ji, Aixin Jing, Yuanyuan Ding, Xinhui Ma, Qilan Qian, Ting Geng, Wenhao Cheng, Meiqi Zhang, Qian Sun, Shaojie Ma, Xiujun Wang, Qing Yuan, Menghan Xu, Jingting Qin, Lin Ma, Jiayan Yang, Jingliang He, Qianming Du, Mengbei Xia, Yuting Xu, Ziyun Chen, Lan Zhu, Wei Liu, Shunfang Liu, Bin Liu   +24 more
doaj   +1 more source

Discovery of a long-acting nanocrystal formulation of INND-2201, a new co-drug of pregabalin and palmitoylethanolamide with synergistic analgesic effects

Pharmaceutical Science Advances
Chronic pain is a global health problem affecting approximately 30% of the adult population worldwide. Currently available painkillers often showed limited efficacy or serious adverse effects and require frequent administration to maintain therapeutic ...
Xiao-Min Han, Yang Xiao, Chao-Nan Huang, Ming-Yue Yin, Ben Xu, Yang-Yang Song, Tao Zhuang, Gui-Sen Zhang   +7 more
doaj   +1 more source