Results 291 to 300 of about 272,679 (364)

Diagnostic work-up in periprosthetic joint infections of the knee: can the albumin-to-globulin ratio be a screening tool? [PDF]

open access: yesJ Orthop Traumatol
De Mauro D   +8 more
europepmc   +1 more source

Efficacy of ciclosporin monotherapy in non‐severe aplastic anaemia not requiring transfusions: Results from a multicentre phase II study

open access: yesBritish Journal of Haematology, EarlyView.
Summary The efficacy of ciclosporin (CsA) to treat transfusion‐independent non‐severe aplastic anaemia (TI‐NSAA) has not yet been systematically evaluated. We conducted a prospective trial in patients with TI‐NSAA treated with CsA monotherapy. CsA (3.5 mg/kg/day) was administered to patients with TI‐NSAA aged ≥16.
Ken Ishiyama   +14 more
wiley   +1 more source

Endothelial activation and stress index (EASIX) as a biomarker to predict ruxolitinib failure for steroid‐refractory acute graft‐versus‐host disease treatment

open access: yesBritish Journal of Haematology, EarlyView.
Summary Steroid‐refractory acute graft‐versus‐host disease (SR‐aGvHD) remains a significant challenge after haematopoietic cell transplantation (HCT). While ruxolitinib (RUX) has shown efficacy for SR‐aGvHD, failure predictors are poorly defined. We assessed 78 patients from six Canadian centres who received RUX for SR‐aGvHD. Failure‐free survival (FFS)
Sergio Rodriguez‐Rodriguez   +18 more
wiley   +1 more source

Distribution of prolactin and its correlation with insulin resistance in women with polycystic ovary syndrome. [PDF]

open access: yesFront Endocrinol (Lausanne)
Ghobrial S   +7 more
europepmc   +1 more source

Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the EBMT Paediatric Diseases Working Party

open access: yesBritish Journal of Haematology, EarlyView.
We retrospectively evaluated outcomes after a second haematopoietic stem cell transplantation (HSCT) performed between 2000 and 2022 for relapsed acute myeloid leukaemia in 345 children. We found that leukaemia‐free survival, overall survival, graft‐versus‐host disease (GVHD)/relapse‐free survival (GRFS) and relapse incidence improved over time, while ...
Nimrod Buchbinder   +22 more
wiley   +1 more source

Impact of methotrexate‐dosing regimens for GVHD prophylaxis on clinical outcomes of HLA‐matched allogeneic HSCT

open access: yesBritish Journal of Haematology, EarlyView.
Summary Severe graft‐versus‐host disease (GVHD) remains a major complication of allogeneic haematopoietic stem cell transplantation (allo‐HSCT), necessitating optimal immunosuppressive strategies. This retrospective study used data from the Japanese Transplant Registry Unified Management Program to compare three methotrexate (MTX)‐dosing regimens for ...
Tomotaka Suzuki   +17 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen   +3 more
wiley   +1 more source

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