Preoperative Functional Connectivity Predicts Antiparkinson Drug Change after Deep Brain Stimulation
Movement Disorders, EarlyView.Abstract Background Deep brain stimulation (DBS) can effectively ameliorate motor symptoms in Parkinson's disease (PD), but patient outcomes remain variable. Clinical predictors lack reliability and only explain a small proportion of outcome variance, outlining a need for biomarkers that can enhance prediction accuracy.
David Mikhael +9 more
wiley +1 more source
What Evidence Is There That Gadobutrol Causes Increasing Signal Intensity within the Dentate Nucleus and Globus Pallidus on Unenhanced T1W MRI in Patients with RRMS? [PDF]
, 2015 Jacob Agris +2 more
openalex +1 more source
High-frequency oscillations in the internal globus pallidus: a pathophysiological biomarker in Parkinson's disease? [PDF]
, 2020 Luke A. Johnson +15 more
openalex +1 more source
Cholinergic neurons in the basal forebrain of the cat have direct projections to the sensorimotor cortex. [PDF]
, 1982 Previous studies showed that projections from the cells in the substantia innominata to the sensorimotor cortex exist in the monkey and rat and that this group of cortical afferent fibers utilizes acetylcholine as a neurotransmitter.
Kramer, WG, Ribak, CE
core
Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia
Movement Disorders, EarlyView.Abstract Background Tardive dyskinesia (TD) and drug‐induced parkinsonism (DIP) arise from prolonged dopamine antagonist use. Although D2 receptor hypersensitivity in the indirect pathway is a proposed mechanism, the role of the direct pathway remains unclear.
Hiroki Hikichi +6 more
wiley +1 more source
Movement Disorders, EarlyView.The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger +1 more
wiley +1 more source
Expanding the Genetic and Phenotypic Spectrum of DYT‐VPS16: The Importance of Splice‐Site Variants
Movement Disorders, EarlyView.Abstract Background DYT‐VPS16, an early‐onset isolated dystonia caused by variants in the VPS16 gene, has been reported in fewer than 70 patients. Methods We explored the clinical and genotypic spectrum of DYT‐VPS16 by investigating early‐onset dystonia patients with VPS16 variants discovered in our large Biodatabank and through gene‐matching ...
Ana Westenberger +39 more
wiley +1 more source
Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood
Developmental Cognitive NeuroscienceDopaminergic projections from the ventral tegmental area (VTA) to limbic regions play a key role in the initiation and maintenance of substance use; however, the relationship between mesolimbic resting-state functional connectivity (RSFC) and alcohol use
Angelica M. Morales +17 more
doaj +1 more source
Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping. [PDF]
, 2019 The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the treatment of multiple neurological and psychiatric disorders.
Gutierrez, Lorenzo +9 more
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Movement Disorders, EarlyView.Abstract Background Many patients with Parkinson's disease (PD) have motor impairments despite dopaminergic therapy. Low‐intensity transcranial ultrasound stimulation (TUS) is a non‐invasive neuromodulation method with high spatial precision. The effects of motor cortex (M1) and internal globus pallidus (GPi) TUS on PD motor signs and cortical ...
Yi‐Ying Lin +8 more
wiley +1 more source