Results 21 to 30 of about 30,780 (286)
BMC Neurology, 2012 Background Based upon the acquainted loss of dopaminergic neurons in the substantia nigra in Parkinson’s disease (PD), we hypothesised changes in magnetic resonance imaging signal intensities of the basal ganglia to be useful as an additional technical ...
Jesse Sarah +4 more
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Неврология, нейропсихиатрия, психосоматика, 2019 Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and the first one among the nosological entities of parkinsonism.
A. G. Trufanov +5 more
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Evaluation of brain iron content based on magnetic resonance imaging (MRI): comparison among phase value, R2* and magnitude signal intensity. [PDF]
PLoS ONE, 2012 BACKGROUND AND PURPOSE: Several magnetic resonance imaging (MRI) techniques are being exploited to measure brain iron levels increasingly as iron deposition has been implicated in some neurodegenerative diseases.
Shen-Qiang Yan +4 more
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Frontiers in Aging Neuroscience, 2019 The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an important role in the modulation of neuronal excitability.
Xiao-Meng Hao +8 more
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Rethinking the external globus pallidus and information flow in cortico-basal ganglia-thalamic circuits [PDF]
arXiv, 2023 For decades the external globus pallidus (GPe) has been viewed as a passive way-station in the indirect pathway of the cortico-basal ganglia-thalamic (CBGT) circuit, sandwiched between striatal inputs and basal ganglia outputs. According to this model, one-way descending striatal signals in the indirect pathway amplify the suppression of downstream ...
arxiv
A tissue-fraction estimation-based segmentation method for quantitative dopamine transporter SPECT [PDF]
, 2021 Quantitative measures of dopamine transporter (DaT) uptake in caudate, putamen, and globus pallidus (GP) have potential as biomarkers for measuring the severity of Parkinson disease. Reliable quantification of this uptake requires accurate segmentation of the considered regions.
arxiv +1 more source
Intermittent synchronization in a network of bursting neurons [PDF]
Chaos, 21, 033125, 2011, 2011 Synchronized oscillations in networks of inhibitory and excitatory coupled bursting neurons are common in a variety of neural systems from central pattern generators to human brain circuits. One example of the latter is the subcortical network of the basal ganglia, formed by excitatory and inhibitory bursters of the subthalamic nucleus and globus ...
arxiv +1 more source
Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]
PLoS One. 2012; 7(12): e51530, 2012 Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor symptoms of the disorder. Our study explores potential mechanisms behind this intermittent synchrony.
arxiv +1 more source
Mean-field modeling of the basal ganglia-thalamocortical system. I. Firing rates in healthy and parkinsonian states [PDF]
J. Theor. Biol. 257: 642-663 (2009), 2018 Parkinsonism leads to various electrophysiological changes in the basal ganglia-thalamocortical system (BGTCS), often including elevated discharge rates of the subthalamic nucleus (STN) and the output nuclei, and reduced activity of the globus pallidus external segment (GPe).
arxiv +1 more source
Brain Sciences, 2023 Kernicterus is a serious complication of hyperbilirubinemia, caused by neuronal injury due to excessive unconjugated bilirubin (UCB) in specific brain areas.
Nanqin Wang +5 more
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