Evaluation of brain iron content based on magnetic resonance imaging (MRI): comparison among phase value, R2* and magnitude signal intensity. [PDF]
PLoS ONE, 2012 BACKGROUND AND PURPOSE: Several magnetic resonance imaging (MRI) techniques are being exploited to measure brain iron levels increasingly as iron deposition has been implicated in some neurodegenerative diseases.
Shen-Qiang Yan +4 more
doaj +1 more source
Rethinking the external globus pallidus and information flow in cortico-basal ganglia-thalamic circuits [PDF]
arXiv, 2023 For decades the external globus pallidus (GPe) has been viewed as a passive way-station in the indirect pathway of the cortico-basal ganglia-thalamic (CBGT) circuit, sandwiched between striatal inputs and basal ganglia outputs. According to this model, one-way descending striatal signals in the indirect pathway amplify the suppression of downstream ...
arxiv
A tissue-fraction estimation-based segmentation method for quantitative dopamine transporter SPECT [PDF]
, 2021 Quantitative measures of dopamine transporter (DaT) uptake in caudate, putamen, and globus pallidus (GP) have potential as biomarkers for measuring the severity of Parkinson disease. Reliable quantification of this uptake requires accurate segmentation of the considered regions.
arxiv +1 more source
Karak syndrome: a novel degenerative disorder of the basal ganglia and cerebellum [PDF]
, 2003 Two brothers are reported with early onset progressive cerebellar ataxia, dystonia, spasticity, and intellectual decline. • Neuroradiology showed cerebellar atrophy and features compatible with iron deposition in the putamen (including the “eye of ...
Dheyyat, M. +9 more
core +2 more sources
Frontiers in Aging Neuroscience, 2019 The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an important role in the modulation of neuronal excitability.
Xiao-Meng Hao +8 more
doaj +1 more source
Intermittent synchronization in a network of bursting neurons [PDF]
Chaos, 21, 033125, 2011, 2011 Synchronized oscillations in networks of inhibitory and excitatory coupled bursting neurons are common in a variety of neural systems from central pattern generators to human brain circuits. One example of the latter is the subcortical network of the basal ganglia, formed by excitatory and inhibitory bursters of the subthalamic nucleus and globus ...
arxiv +1 more source
Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo [PDF]
, 2006 The functional organization of the basal ganglia (BG) is often defined according to one of two opposing schemes. The first proposes multiple, essentially independent channels of information processing.
Bolam, JP +5 more
core +1 more source
Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]
PLoS One. 2012; 7(12): e51530, 2012 Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor symptoms of the disorder. Our study explores potential mechanisms behind this intermittent synchrony.
arxiv +1 more source
Quantitative Susceptibility Mapping: Contrast Mechanisms and Clinical Applications. [PDF]
, 2015 Quantitative susceptibility mapping (QSM) is a recently developed MRI technique for quantifying the spatial distribution of magnetic susceptibility within biological tissues.
Cronin, Matthew +5 more
core +2 more sources
Brain Sciences, 2023 Kernicterus is a serious complication of hyperbilirubinemia, caused by neuronal injury due to excessive unconjugated bilirubin (UCB) in specific brain areas.
Nanqin Wang +5 more
doaj +1 more source