Results 271 to 280 of about 107,331 (315)

Inherited Diseases of the Glomerular Basement Membrane

American Journal of Kidney Diseases, 1994
The inherited diseases of the glomerular basement membrane include Alport's syndrome (AS), nail-patella syndrome, and thin basement membrane nephropathy. Classical AS is inherited in an X-linked manner and accounts for approximately 85% of the cases. Its manifestations include hematuria, sensorineural hearing loss, ocular defects, and a progression to ...
William S. Hammond, William S. Hammond, Bruce A. Molitoris, Kenneth A. Bodziak   +3 more
openaire   +3 more sources

Molecular Sieving by Glomerular Basement Membrane

Nature, 1967
OF the three layers of the glomerular capillary wall—endothelial cells, basement membrane and epithelial cells—the basement membrane appears to be the only complete barrier between the plasma and the glomerular filtrate1,2. Support for the view that the basement membrane is the most important filtering mechanism was provided by the studies on ferritin ...
Linda Hutton, Linda Hutton, Flora Y. Y. Huang, Flora Y. Y. Huang, Norman Kalant, Norman Kalant   +5 more
openaire   +3 more sources

Pathology of glomerular basement membrane nephropathy

Current Opinion in Nephrology and Hypertension, 1994
Studies of the molecular pathology of glomerular basement membrane have led to the discovery of four novel chains of type IV collagen, the latest of which is the alpha 6(IV) chain. Three chains have been shown to be directly involved in the pathogenesis of Goodpasture syndrome, Alport syndrome, and Alport posttransplantation antiglomerular basement ...
Raghuram Kalluri, Karl Tryggvason, Billy G. Hudson   +2 more
openaire   +3 more sources

Immunogenetics of the Glomerular Basement Membrane

1990
The nature of the genetic defect responsible for the abnormalities of kidney, cochlea, and eye that are characteristic of Alport’s syndrome has been a matter of interest to nephrologists, geneticists, and pathologists for decades. In recent years this entity has been the subject of intensive laboratory research, the results of which indicate that the ...
Clifford E. Kashtan, Alfred F. Michael
openaire   +2 more sources

Inherited diseases of the glomerular basement membrane [PDF]

Nature Clinical Practice Nephrology, 2008
The glomerular basement membrane (GBM) is a specialized form of basement membrane that has a major role in the maintenance of the glomerular filtration barrier. Like all basement membranes, it contains four main components: type IV collagen, laminin, nidogen, and heparan sulfate proteoglycans.
openaire   +2 more sources

Glomerular Basement Membrane Antigens

1983
In experimental nephritis produced by the administration of nephrotoxic serum, there is in vivo localization of heterologous immunoglobulin antibodies in a smooth linear pattern along the glomerular basement membrane (GBM) (Hammer and Dixon, 1963). Nephrotoxic serum, produced by immunization with isolated GBM, reacts in vitro by fixing not only to GBM,
Mark S. Schiffer, Kathleen M. Carmody, Alfred J. Fish, Alfred E. Michael   +3 more
openaire   +2 more sources

Genetic Disorders of Glomerular Basement Membranes

Nephron Clinical Practice, 2010
This review provides current information about glomerular disorders that arise directly from inherited abnormalities in extracellular matrix proteins intrinsic to the glomerular basement membrane (Alport syndrome, thin basement membrane nephropathy, HANAC syndrome and Pierson syndrome).
Clifford E. Kashtan, Yoav Segal
openaire   +2 more sources

The Glomerular Basement Membrane

1981
The basement membrane of the glomerular capillaries of the mammalian kidney has been a favorite object for studies on the structure, function, and composition of basement membranes because of its important biological role in glomerular filtration of macromolecules, and because of the relative ease with which it can be isolated for study, free from ...
openaire   +2 more sources

The glomerular basement membrane in lupus nephritis

Microscopy Research and Technique, 1994
AbstractSystemic lupus erythematosus is a disease that is particularly suited for studies of glomerular basement membrane pathology. Classification of the renal pathology of lupus nephritis is usually based on light microscopic features, combined with immunofluorescence findings and electron microscopic alterations.
openaire   +3 more sources

Clinical features and outcomes of anti-glomerular basement membrane disease in older patients.

American Journal of Kidney Diseases, 2011
BACKGROUND Anti-glomerular basement membrane (GBM) disease is being recognized increasingly in older patients. Disease presentation and outcomes of these patients are unclear. STUDY DESIGN Case series.
Z. Cui, Juan Zhao, Xiao‐yu Jia, Sai-nan Zhu, Ming-hui Zhao   +4 more
semanticscholar   +1 more source