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Role and Mechanisms of Tyro3 in Podocyte Biology and Glomerular Disease [PDF]

Kidney Diseases
Background: Podocyte loss occurs in both primary and secondary glomerular diseases, leading to the progression of kidney disease. A large body of evidence suggests that apoptosis and detachment are the mechanisms mediating the reduction in podocyte ...
Lulin Min, Yixin Chen, Fang Zhong, Leyi Gu, Kyung Lee, John Cijiang He   +5 more
doaj   +2 more sources

Glomerular Diseases [PDF]

Clinical Journal of the American Society of Nephrology, 2014
FSGS is a lesion, not a disease. The separation into primary FSGS (a result of immunologic-mediated injury) versus secondary FSGS (related to a variety of causes) is often difficult. Even when this particular issue is carefully evaluated, the therapeutic implications are not always apparent.
Bhadran, Bose, Daniel, Cattran
openaire   +4 more sources

Estradiol protects female mice from hyperuricemia induced by PCB138 exposure

Ecotoxicology and Environmental Safety, 2023
Polychlorinated biphenyls (PCBs) are a type of persistent organic pollutant (POP). Our previous study demonstrated that exposure to 0.5–50 μg/kg bw PCB138 during postnatal days (PND) 3–21 led to elevated serum uric acid (UA) levels and kidney injury in ...
Changqian Liu, Jinpeng Ruan, Fengkai Ruan, Xiaoyan Ding, Changshun Han, Chaoqun Huang, Hongbin Zhong, Chengyong He, Zhenghong Zuo, Jiyi Huang   +9 more
doaj   +1 more source

The hepatoprotective effects of Herbt Tea Essences on phenanthrene-induced liver damage in mice

Ecotoxicology and Environmental Safety, 2023
Phenanthrene (Phe), one of the most frequently occurring pollutants in nature, can cause substantial damage to the human liver. Herbt Tea Essences (HTE), a kind of black tea extract with strong anti-inflammatory activity, can protect humans against ...
Lingxiao Ye, Xiaoyan Ding, Changqian Liu, Fengkai Ruan, Hongbin Zhong, Rongfu Lv, Yi Yu, Chengyong He, Zhenghong Zuo, Jiyi Huang   +9 more
doaj   +1 more source

Glomerular Disease in Temporal Association with SARS-CoV-2 Vaccination: A Series of 29 Cases

Kidney360, 2021
Visual Abstract Key Points This study identified 29 patients with glomerular disease development in close temporal association with SARS-CoV-2 immunization.
Tiffany N. Caza, C. Cassol, Nidia C. Messias, Andrew Hannoudi, R. Haun, P. Walker, R. M. May, Regan M. Seipp, Elizabeth J. Betchick, H. Amin, Mandolin S. Ziadie, Michael M. Haderlie, Joy Eduwu-Okwuwa, Irina Vancea, M. Seek, Essam B. Elashi, Ganesh Shenoy, Sayeed Khalillullah, J. Flaxenburg, J. Brandt, Matthew J. Diamond, A. Frome, E. Kim, G. Schlessinger, Erlandas Ulozas, Janice L. Weatherspoon, Ethan Thomas Hoerschgen, Steven L. Fabian, Sung Yong Bae, Bilal Iqbal, Kanwalijit K Chouhan, Zeina Karam, J. T. Henry, C. Larsen   +33 more
semanticscholar   +1 more source

Glomerular Disease [PDF]

Clinical Journal of the American Society of Nephrology, 2014
The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives aimed at improved understanding of kidney function and disease progression. Over the past 2 years, 1600 participants posted almost 300 ideas covering all areas of
Roger C, Wiggins, Charles E, Alpers, Lawrence B, Holzman, John C, He, David J, Salant, Sumant S, Chugh, Rama, Natarajan, Howard, Trachtman, Lauren, Brasile, Robert A, Star, Krystyna E, Rys-Sikora, Marva M, Moxey-Mims, Michael F, Flessner   +12 more
openaire   +3 more sources

Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice

Ecotoxicology and Environmental Safety, 2022
Black phosphorus quantum dots (BPQDs) are considered to have wide application prospects due to their excellent properties. However, there is no study on the effect of BPQDs on glucose metabolism.
Jie Zeng, Fengkai Ruan, Mingtao Wu, Jiaying Xu, Zhenghong Zuo, Yi Yu, Chengyong He   +6 more
doaj   +1 more source

The Rationale and Evidence for SGLT2 Inhibitors as a Treatment for Nondiabetic Glomerular Disease

Glomerular Diseases, 2021
Background: Recent studies show that sodium-glucose cotransporter 2 inhibitors (SGLT2i), originally approved for glycemic control in patients with type 2 diabetes, also exert renoprotective effects independently from effects on dysglycemia.
Kana N. Miyata, Shao-Ling Zhang, J. Chan
semanticscholar   +1 more source

The Biological Significance and Implications of Planar Cell Polarity for Nephrology

Frontiers in Physiology, 2021
The orientation of cells in two-dimensional and three-dimensional space underpins how the kidney develops and responds to disease. The process by which cells orientate themselves within the plane of a tissue is termed planar cell polarity. In this Review,
Eugenia Papakrivopoulou, Eugenia Papakrivopoulou, Daniyal J. Jafree, Daniyal J. Jafree, Charlotte H. Dean, David A. Long   +5 more
doaj   +1 more source

Glomerular Disease Workshop [PDF]

Journal of the American Society of Nephrology, 2005
Recent observations regarding intrinsic glomerular cell biology, particularly in the podocyte, have provided exciting new insights into potential pathogenic mechanisms of human glomerular disease. Although both immune and nonimmune mechanisms of glomerular injury have been studied previously, experimental models of disease and recent techniques that ...
Catherine M, Meyers, Mark, Geanacopoulos, Lawrence B, Holzman, David J, Salant   +3 more
openaire   +2 more sources