Results 111 to 120 of about 9,805,880 (332)

Single-Cell RNA Profiling of Glomerular Cells Shows Dynamic Changes in Experimental Diabetic Kidney Disease.

Journal of the American Society of Nephrology, 2019
BACKGROUND Recent single-cell RNA sequencing (scRNA-seq) analyses have offered much insight into cell-specific gene expression profiles in normal kidneys.
Jia Fu, K. Akat, Zeguo Sun, Weijia Zhang, D. Schlondorff, Zhihong Liu, T. Tuschl, Kyung Lee, J. He   +8 more
semanticscholar   +1 more source

Nuclear medicine: investigation of renal function in small animal medicine [PDF]

, 2011
Kidney function investigations in veterinary medicine are traditionally based on blood analysis (blood urea nitrogen (BUN) and serum creatinine concentration) and / or urinalysis (urine specific gravity, protein-to-creatinine ratio or fractional ...
De Sadeleer, Carlos, Dobbeleir, André, Ham, Hamphrey, Peremans, Kathelijne, Slegers, Guido, van Bree, Henri, Vandermeulen, Eva, Vermeire, Simon   +7 more
core  

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK [PDF]

, 2015
To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and ...
ARDISSINO, ARDISSINO, ARONSON, BIRNBAUM, BLOMBERY, BOURHY, BOYCE, BURNENS, CARPENTER, CHANTREY, COWAN, DELL'ORCO, DICKINSON, EUBIG, FERRER, FISCHER, FOURNEL, GARCIA, GOLDFARB, GREENE, HENDRICKS, HERTZKE, HOLLOWAY, KAVANAGH, LI, MILFORD, MONAHAN, MOORE, MORRIS, MUNDAY, NORIS, PASS, REBAR, RENTKO, ROBY, ROTERMUND, RUGGENENTI, SALVADORI, SYKES, TANGEMAN, TARR, TARR, UCHIDA, VAN DEN INGH, VICTORIA, WAIKAR, WALKER   +46 more
core   +1 more source

Stiff to Soft: A Protein‐Based Buffer Layer for Improving the Long‐Term Performance of Microneedle Sensors

Advanced Materials, EarlyView.
To enhance stability and long‐term biocompatibility of wearable microneedle sensors, a crosslinking‐recombination bovine serum albumin material is used as a buffer layer coated on microneedle sensors. This coating layer possesses a unique stiff‐to‐soft transition function balancing the mechanical stiffness desired for puncturing and soft required for ...
Lihao Guo, Youbin Zheng, Shuxiang Xu, Bingbing Feng, Kan Wang, Rou Huang, Gandong Zhou, Chutong Liu, Rawan Omar, Danyao Qu, Jinbao Li, Min Zhang, Weiwei Wu, Guangjian Zhang, Lina Huang, Hossam Haick, Miaomiao Yuan   +16 more
wiley   +1 more source

Consequences of Glomerular Hyperfiltration: The Role of Physical Forces in the Pathogenesis of Chronic Kidney Disease in Diabetes and Obesity

Nephron, 2019
Background: Glomerular hyperfiltration (GH) is a hallmark of renal dysfunction in diabetes and obesity. Recent clinical trials demonstrated that SGLT2 inhibitors are renoprotective, possibly by abating hyperfiltration.
A. Chagnac, B. Zingerman, B. Rozen-Zvi, M. Herman-Edelstein   +3 more
semanticscholar   +1 more source

Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study. [PDF]

, 2018
IntroductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury.
Bennett, Michael, Cushman, Mary, Dubin, Ruth F, Judd, Suzanne, Parikh, Chirag, Peralta, Carmen A, Powe, Neil, Sarnak, Mark, Scherzer, Rebecca, Shlipak, Michael, Warnock, David G   +10 more
core  

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

The International Society of Glomerular Disease: Building the Future of Glomerular Medicine

Glomerular Diseases, 2023
Laurel J. Damashek, Sharon G. Adler, Joshua M. Tarnoff, Tobias B. Huber   +3 more
doaj   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Steroid-Resistant Nephrotic Syndrome due to NPHS2 Variants Is Not Associated With Posttransplant Recurrence

Kidney International Reports
Introduction: Unlike idiopathic nephrotic syndrome (NS), hereditary podocytopathies are not expected to recur after kidney transplantation. However, some reports of posttransplant recurrence of NS in patients carrying variants in the NPHS2 gene have been
Jessica Kachmar, Olivia Boyer, Beata Lipska-Ziętkiewicz, Vincent Morinière, Olivier Gribouval, Laurence Heidet, Irena Balasz-Chmielewska, Elisa Benetti, Sylvie Cloarec, Dagmar Csaicsich, Stéphane Decramer, Jutta Gellermann, Vincent Guigonis, Julien Hogan, Aysun Karabay Bayazit, Anette Melk, Nazym Nigmatullina, Jun Oh, Fatih Ozaltin, Bruno Ranchin, Michel Tsimaratos, Agnes Trautmann, Corinne Antignac, Franz Schaefer, Guillaume Dorval, Mounia Boutaba, Dagmar Csaiscich, Sergay Baiko, Marta Azocar, Lily Quiroz, Lina Maria Serna Higuita, Jiří Dušek, Bruno Ranchin, Adriane Zaloszyc, Tinatin Davitaia, Jutta Gellermann, Jun Oh, Anette Melk, Franz Schaefer, Hagen Staude, Nikoleta Printza, Kalman Tory, Alaleh Gheissari, Giuseppe Remuzzi, Andrea Pasini, Gian Marco Ghiggeri, Gianluigi Ardissino, Elisa Benetti, Francesco Emma, Roberta Camilla, Nazym Nigmatullina, Bilal Aoun, Chebl Mourani, Pauline Abou-Jaoudé, Augustina Jankauskiene, Anna Wasilewska, Lidia Hyla Klekot, Aleksandra Zurowska, Dorota Drozdz, Marcin Tkaczyk, Przemysław Sikora, Danuta Ostalska, Andrzej Brodkiewicz, Mieczyslaw Litwin, Małgorzata Panczyk-Tomaszewska, Anna Medyńska, Maria Szczepanska, Alberto Caldas Afonso, Helena Jardim, Adrian Lungu, Alexej Tsygin, Larisa Prikhodina, Dusan Paripovic, Radovan Bogdanovic, Rafael T. Krmar, Bassam Saeed, Ali Anarat, Ayse Balat, Z. Esra Baskin, Nilgun Cakar, Ozlem Erdogan, Birsin Özcakar, Fatih Ozaltin, Onur Sakallioglu, Oguz Soylemezoglu, Sema Akman, Faysal Gok, Salim Caliskan, Cengiz Candan, Alev Yilmaz, Betul Sozeri, Ipek Akil, Pelin Ertan, Ozan Özkaya, Mukaddes Kalyoncu, Martin Bitzan, Svitlana Formina, Roman Sobko   +97 more
doaj   +1 more source