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CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.
American Journal of Kidney Diseases, 2019 RATIONALE & OBJECTIVES
Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms.L. Mariani, A. Bomback, P. Canetta, Michael F. Flessner, M. Helmuth, M. Hladunewich, J. Hogan, Krzysztof Kiryluk, P. Nachman, Cynthia C. Nast, M. Rheault, Dana V. Rizk, H. Trachtman, Scott E. Wenderfer, Corinna Bowers, Peg Hill-Callahan, M. Marasà, Caroline Poulton, Adelaide Revell, S. Vento, L. Barisoni, Daniel C. Cattran, Vivette D. D'Agati, J. C. Jennette, Jon B. Klein, L. Laurin, K. Twombley, R. Falk, A. Gharavi, B. Gillespie, D. Gipson, Larry A. Greenbaum, L. Holzman, M. Kretzler, Bruce M. Robinson, W. Smoyer, L. Guay-Woodford, Wooin Ahn, Gerald B. Appel, Revekka Babayev, Ibrahim Batal, Eric R. Brown, E. Campenot, P. Canetta, Lucrezia Carlassara, Brenda Chan, Debanjana Chatterjee, Vivette D. D'Agati, Elisa Delbarba, Samriti Dogra, Hilda E. Fernandez, B. Foroncewicz, G. Ghiggeri, William H. Hines, S. Ali Husain, N. Jain, P. Khairallah, B. H. Kil, A. Jeyabalan, W. L. Lau, Fangming Lin, Francesca Lugani, G. Markowitz, S. Mohan, Xueru Mu, K. Mucha, T. Nickolas, Stacy E. Piva, J. Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, S. Sanna-Cherchi, D. Santoriello, Shayan Shirazian, M. Barry Stokes, N. Yu, Anthony M. Valeri, Ronald Zviti, A. Al-Uzri, Josephine M. Ambruzs, I. Ashoor, D. Aviles, Rossana Baracco, J. Barcia, Sharon M. Bartosh, C. Belsha, Michael C. Braun, Yi Cai, V. Chernitskiy, A. Chishti, D. Claes, Kira Clark, Carl H. Cramer, Keefe Davis, Amy Dutcher, E. Erkan, D. Feig, M. Freundlich, J. Gaut, R. Gbadegesin, Melisha G. Hanna, G. Hidalgo, D. Hooper, T. Hunley, Amrish Jain, M. Kallash, M. Kamel, Myda Khalid, T. Kump, J. Lane, H. Liapis, J. Mahan, N. Mathews, C. Nester, C. Pan, Larry T. Patterson, H. Patel, A. Raad, Cynthia Silva, Rajasree Sreedharan, T. Srivastava, J. Steinke, Susan Sumner, Tetyana L Vasylyeva, Chia-shi Wang, Donald J. Weaver, Craig S. Wong, H. Yin, Anand Achanti, S. Almaani, I. Ayoub, M. Budisavljevic, Maggie D’Angelo, V. Derebail, Huma Fatima, R. Falk, A. Fogo, K. Gibson, Dorey A. Glenn, S. Hogan, K. Jain, B. Julian, J. Kidd, H. D. Massey, A. Mottl, Shannon Murphy, T. Nadasdy, J. Novak, Samir M. Parikh, Caroline Poulton, T. B. Powell, B. Reeve, M. Renfrow, M. Reynolds, Dana V. Rizk, B. Rovin, Virginie Royal, M. Saha, Neil S. Sanghani, S. Self, S. Adler, N. Alachkar, C. Alpers, Raed Bou Matar, C. Avila-Casado, S. Bagnasco, Emily Brede, Elizabeth Brown, Daniel C. Cattran, M. Choi, G. Contreras, K. Dell, D. DeWalt, M. Denburg, R. Dukkipati, F. Fervenza, A. Fornoni, C. Gadegbeku, P. Gipson, Anny Gonzalez-Zea, Leah Hasely, Elizabeth M. Hendren, S. Hingorani, M. Hladunewich, J. Hogan, Jean Hou, J. A. Jefferson, K. Jhaveri, D. Johnstone, F. Kaskel, A. Kogan, J. Kopp, R. Lafayette, K. Lemley, L. Malaga-Dieguez, K. Meyers, A. Neu, M. O'shaughnessy, John F. O'Toole, A. Oliverio, Matthew Palmer, R. Parekh, Renée A. Pitter, H. Reich, Kimberly J. Reidy, Helbert Rondon, K. Sambandam, M. Sampson, J. Sedor, D. Selewski, C. Sethna, J. Schelling, J. Sperati, Agnes Swiatecka-Urban, K. Tuttle, M. Waldman, J. Weisstuch, R. Wiggins, David S. Williams, C. Winkler, E. Young, O. Zhdanova, Charlotte A. Beil, R. Eikstadt, B. Gillespie, J. Graff, S. Hewitt, Emily G Herreshoff, Chrysta Lienczewski, Sarah A. Mansfield, L. Mariani, K. McCullough, Nicholas Moore, Bruce M. Robinson, Melissa Sexton, J. Troost, Matthew Wladkowski, J. Zee, D. Zinsser +238 moresemanticscholar +1 more sourceRandomized Clinical Trial Design to Assess Abatacept in Resistant Nephrotic Syndrome
Kidney International Reports, 2018 Treatment-resistant nephrotic syndrome is a rare form of glomerular disease that occurs in children and adults. No Food and Drug Administration−approved treatments consistently achieve remission of proteinuria and preservation of kidney function.Howard Trachtman, Debbie S. Gipson, Michael Somers, Cathie Spino, Sharon Adler, Lawrence Holzman, Jeffrey B. Kopp, John Sedor, Sandra Overfield, Ayanbola Elegbe, Michael Maldonado, Anna Greka +11 moredoaj +1 more sourceThe Risk of Severe Infections Following Rituximab Administration in Patients With Autoimmune Kidney Diseases: Austrian ABCDE Registry Analysis
Frontiers in Immunology, 2021 ObjectiveTo characterize the incidence, type, and risk factors of severe infections (SI) in patients with autoimmune kidney diseases treated with rituximab (RTX).MethodsWe conducted a multicenter retrospective cohort study of adult patients with immune ...Balazs Odler, Martin Windpessl, Martin Windpessl, Marcell Krall, Maria Steiner, Regina Riedl, Carina Hebesberger, Martin Ursli, Emanuel Zitt, Karl Lhotta, Marlies Antlanger, Daniel Cejka, Philipp Gauckler, Martin Wiesholzer, Marcus Saemann, Alexander R. Rosenkranz, Kathrin Eller, Andreas Kronbichler, Andreas Kronbichler +18 moredoaj +1 more sourceSGLT2 Inhibitors and the Diabetic Kidney [PDF]
, 2016 Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. Blood glucose and blood pressure control reduce the risk of developing this complication; however, once DN is established, it is only possible to slow progression ...Busetto, Luca, Fioretto, Paola, Rossato, Marco, Vettor, Roberto, Zambon, Alberto +4 morecore +1 more sourcePodocyte-specific deletion of miR-146a increases podocyte injury and diabetic kidney disease
Frontiers in Medicine, 2022 Diabetic glomerular injury is a major complication of diabetes mellitus and is the leading cause of end stage renal disease (ESRD). Healthy podocytes are essential for glomerular function and health.Xiaobo Li, Ishwarya Venkatesh, Veronica Villanueva, Huiting Wei, Terese Geraghty, Anugraha Rajagopalan, Richard W. Helmuth, Mehmet M. Altintas, Hafeez M. Faridi, Vineet Gupta, Vineet Gupta +10 moredoaj +1 more sourceOrganoid single cell profiling identifies a transcriptional signature of glomerular disease.
JCI Insight, 2019 Podocyte injury is central to many forms of kidney disease, but transcriptional signatures reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo.J. Harder, R. Menon, E. Otto, Jian Zhou, S. Eddy, Noel L. Wys, C. O'Connor, Jinghui Luo, V. Nair, C. Cebrián, J. Spence, M. Bitzer, O. Troyanskaya, J. Hodgin, R. Wiggins, Benjamin S. Freedman, M. Kretzler +16 moresemanticscholar +1 more sourceNoninvasive Urinary Monitoring of Progression in IgA Nephropathy. [PDF]
, 2019 Standard methods for detecting and monitoring of IgA nephropathy (IgAN) have conventionally required kidney biopsies or suffer from poor sensitivity and specificity.Fervenza, Fernando C, Lafayette, Richard A, Sarwal, Minnie M, Sarwal, Reuben D, Yang, Joshua YC +4 morecore +1 more sourceFactor B Inhibition with Iptacopan in Recurrent C3 Glomerulopathy Following Kidney Transplant: A Report of Two Cases
Kidney MedicineC3 glomerulopathy is a rare disease caused by fluid phase dysregulation of the alternative complement pathway. Currently, treatment depends on clinical and histological severity and includes nephroprotection, unspecific immunosuppression, and terminal ...Víctor J. Escudero-Saiz, Ángela Gonzalez, Adriana García-Herrera, Ana B. Larque, Andrew S. Bomback, Laura Morantes, Marta Martínez-Chillarón, Júlia Ollé, Elena Guillén, Marc Xipell, Alicia Molina-Andújar, Diana Rodríguez, Elena Cuadrado, Judit Cacho, Carolt Arana, Núria Esforzado, Carla Bastida, Esteban Poch, Fritz Diekman, David Cucchiari, Luis F. Quintana, Miquel Blasco +21 moredoaj +1 more source