Results 41 to 50 of about 9,805,880 (332)

Mechanisms of Proteinuria in HIV

Frontiers in Medicine, 2021
Proteinuria is common in the setting of HIV infection, and may reflect comorbid kidney disease, treatment-related nephrotoxicity, and HIV-related glomerular diseases.
Gentzon Hall, Gentzon Hall, Christina M. Wyatt, Christina M. Wyatt   +3 more
doaj   +1 more source

Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review

Cell Communication and Signaling
Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that affects millions of people worldwide. It is characterized by proteinuria, glomerular damage, and renal fibrosis, leading to end-stage renal disease, and the ...
Shiwan Hu, Xing Hang, Yu Wei, Han Wang, Lili Zhang, Linhua Zhao   +5 more
semanticscholar   +1 more source

Anti-Glomerular Basement Membrane Disease

Definitions, 2020
Anti-glomerular basement membrane disease (anti-GBM) is a rare but well-characterized cause of glomerulonephritis. It is defined by the presence of autoantibodies directed at specific antigenic targets within the glomerular and/or pulmonary basement ...
A. Rees
semanticscholar   +1 more source

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. [PDF]

, 2006
BackgroundGlomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans.
Cosgrove, Dominic, Kalluri, Raghu, Khurana, Mona, Rao, Velidi H, Rougier, Jean-Philippe, Shield, Charles F, Werb, Zena, Werner, Michelle C, Zeisberg, Michael   +8 more
core   +3 more sources

The Similarities and Differences Between Glomerular vs. Non-glomerular Diagnoses on Intelligence and Executive Functions in Pediatric Chronic Kidney Disease: A Brief Report

Frontiers in Neurology, 2021
Pediatric chronic kidney disease (CKD) appears to be a heterogeneous group of conditions, but this heterogeneity has not been explored with respect to its impact on neurocognitive functioning.
Stephen R. Hooper, Rebecca J. Johnson, Marc Lande, Matthew Matheson, Shlomo Shinnar, Amy J. Kogon, Lyndsay Harshman, Joann Spinale, Arlene C. Gerson, Bradley A. Warady, Susan L. Furth   +10 more
doaj   +1 more source

The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression

Nature Communications, 2019
The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood.
H. Lazareth, Carole Hénique, O. Lenoir, Victor G. Puelles, M. Flamant, G. Bollée, C. Fligny, Marine Camus, Lea Guyonnet, Corinne Millien, F. Gaillard, Anna Chipont, B. Robin, S. Fabrega, N. Dhaun, E. Camerer, O. Kretz, F. Grahammer, Fabian Braun, T. Huber, D. Nochy, C. Mandet, P. Bruneval, L. Mesnard, E. Thervet, A. Karras, F. Le Naour, E. Rubinstein, C. Boucheix, A. Alexandrou, M. Moeller, C. Bouzigues, P. Tharaux   +32 more
semanticscholar   +1 more source

Biological Pathways and Potential Targets for Prevention and Therapy of Chronic Allograft Nephropathy [PDF]

, 2014
Renal transplantation (RT) is the best option for patients with end-stage renal disease, but the half-life is limited to a decade due to progressive deterioration of renal function and transplant failure from chronic allograft nephropathy (CAN), which is
Haylor, John, Shrestha, Badri Man
core   +3 more sources

Immunosuppression Exposure and Risk of Infection-Related Acute Care Events in Patients With Glomerular Disease: An Observational Cohort StudyPlain-Language Summary

Kidney Medicine, 2022
Rationale & Objective: Infections cause morbidity and mortality in patients with glomerular disease. The relative contributions from immunosuppression exposure and glomerular disease activity to infection risk are not well characterized.
Dorey A. Glenn, Jarcy Zee, Sarah Mansfield, Michelle M. O’Shaughnessy, Andrew S. Bomback, Keisha Gibson, Larry A. Greenbaum, Laura Mariani, Ronald Falk, Susan Hogan, Amy Mottl, Michelle R. Denburg   +11 more
doaj   +1 more source

Using Electronic Health Record Data to Rapidly Identify Children with Glomerular Disease for Clinical Research.

Journal of the American Society of Nephrology, 2019
BACKGROUND The rarity of pediatric glomerular disease makes it difficult to identify sufficient numbers of participants for clinical trials. This leaves limited data to guide improvements in care for these patients.
M. Denburg, H. Razzaghi, L. C. Bailey, Danielle E. Soranno, A. Pollack, V. Dharnidharka, M. Mitsnefes, W. Smoyer, M. Somers, J. Zaritsky, J. Flynn, D. Claes, B. Dixon, M. Benton, L. Mariani, Christopher B. Forrest, S. Furth   +16 more
semanticscholar   +1 more source

Adriamycin-Induced Nephropathy is Robust in N and Modest in J Substrain of C57BL/6

Frontiers in Cell and Developmental Biology, 2022
Adriamycin (ADR)-induced nephropathy remains the leading model to study human primary focal segmental glomerulosclerosis (FSGS), a common pathway for podocyte damage and glomerular loss of function that leads to chronic kidney disease.
Claire Bryant, Rachel Cianciolo, Rachel Cianciolo, Rajgopal Govindarajan, Rajgopal Govindarajan, Shipra Agrawal, Shipra Agrawal   +6 more
doaj   +1 more source