Results 1 to 10 of about 169,139 (203)

Glomerular hyperfiltration as a therapeutic target for CKD. [PDF]

Nephrol Dial Transplant
The global burden of chronic kidney disease (CKD) is high and increasing. Early diagnosis and intervention are key to improve outcomes. Single-nephron glomerular hyperfiltration is an early pathophysiologic manifestation of CKD that may result in ...
Kanbay M, Copur S, Bakir CN, Covic A, Ortiz A, Tuttle KR.   +5 more
europepmc   +5 more sources

Glomerular Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 Diabetes: A 21-Year Longitudinal Study. [PDF]

Diabetes Care, 2023
OBJECTIVE To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in patients with diabetes.
Moriconi D, Sacchetta L, Chiriacò M, Nesti L, Forotti G, Natali A, Solini A, Tricò D.   +7 more
europepmc   +5 more sources

Glomerular hyperfiltration and hypertrophy: an evaluation of maximum values in pathological indicators to discriminate “diseased” from “normal” [PDF]

Frontiers in Medicine, 2023
The success of sodium-glucose cotransporter 2 inhibitors and bariatric surgery in patients with chronic kidney disease has highlighted the importance of glomerular hyperfiltration and hypertrophy in the progression of kidney disease. Sustained glomerular
Hiroshi Kataoka, Kosaku Nitta, Junichi Hoshino   +2 more
doaj   +3 more sources

Update on Pathogenesis of Glomerular Hyperfiltration in Early Diabetic Kidney Disease [PDF]

Frontiers in Endocrinology, 2022
In the existing stages of diabetic kidney disease (DKD), the first stage of DKD is called the preclinical stage, characterized by glomerular hyperfiltration, an abnormally elevated glomerular filtration rate.
Yang Yang, Gaosi Xu
doaj   +3 more sources

Hemodynamic and biological correlates of glomerular hyperfiltration in sickle cell patients before and under renin–angiotensin system blocker [PDF]

Scientific Reports, 2021
Glomerular hyperfiltration alone or associated with albuminuria is a well-known feature of sickle cell associated nephropathy. Though, glomerular hyperfiltration is currently considered to be related to a high renal plasma flow and chronic hemolysis ...
Jean-Philippe Haymann, Nadjib Hammoudi, Marine Livrozet, Aline Santin, Sarah Mattioni, Emmanuel Letavernier, Vincent Frochot, Camille Saint Jacques, Olivier Steichen, Gilles Grateau, Michel Chaignon, François Lionnet   +11 more
doaj   +3 more sources

Non-Alcoholic Fatty Liver Disease Is Associated with Kidney Glomerular Hyperfiltration in Adults with Metabolic Syndrome. [PDF]

J Clin Med, 2021
Background: Non-alcoholic fatty liver disease (NAFLD) is a risk factor for the development of chronic kidney disease (CKD), which is early marked by kidney glomerular hyperfiltration.
Abbate M, Mascaró CM, Montemayor S, Casares M, Gómez C, Ugarriza L, Tejada S, Abete I, Zulet MA, Sureda A, Martínez JA, Tur JA.   +11 more
europepmc   +4 more sources

Glomerular hyperfiltration is associated with dementia: A nationwide population-based study. [PDF]

PLoS ONE, 2020
BACKGROUND:Glomerular hyperfiltration may be a clinical phenotype of endothelial dysfunction. Endothelial dysfunction may cause vascular dementia through the deterioration of cerebral blood flow.
Min Woo Kang, Sehoon Park, Soojin Lee, Yeonhee Lee, Semin Cho, Kyungdo Han, Hanna Cho, Yaerim Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim   +15 more
doaj   +3 more sources

Glomerular hyperfiltration: part 2—clinical significance in children [PDF]

Pediatric Nephrology, 2022
Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease, and solitary functioning kidney. Yet, the pathophysiological mechanisms vary from one disease to another and are not well understood.
Oyindamola C. Adebayo, Agathe B. Nkoy, Lambertus P. van den Heuvel, Veerle Labarque, Elena Levtchenko, Pierre Delanaye, Hans Pottel   +6 more
semanticscholar   +7 more sources

Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women. [PDF]

PLoS ONE, 2017
BACKGROUND:It is unclear whether sleep duration and quality are associated with chronic kidney disease (CKD) and glomerular hyperfiltration. The aim of this study was to examine the association of sleep duration and quality with CKD and glomerular ...
Chan-Won Kim, Yoosoo Chang, Eunju Sung, Kyung Eun Yun, Hyun-Suk Jung, Byung-Joon Ko, Min-Jung Kwon, Young Youl Hyun, Kyu-Beck Lee, Hyang Kim, Hocheol Shin, Seungho Ryu   +11 more
doaj   +4 more sources

Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment. [PDF]

J Am Soc Nephrol, 2017
An absolute, supraphysiologic elevation in GFR is observed early in the natural history in 10%-67% and 6%-73% of patients with type 1 and type 2 diabetes, respectively. Moreover, at the single-nephron level, diabetes-related renal hemodynamic alterations as an adaptation to reduction in functional nephron mass and/or in response to prevailing metabolic
Tonneijck L, Muskiet MH, Smits MM, van Bommel EJ, Heerspink HJ, van Raalte DH, Joles JA.   +6 more
europepmc   +7 more sources