Results 91 to 100 of about 169,139 (203)

Albuminuria Predicts a Rapid Decline in Kidney Function in 2 International, Longitudinal Cohorts of Adults With Sickle Cell Anemia

American Journal of Hematology, Volume 101, Issue 2, Page 304-310, February 2026.
ABSTRACT Chronic kidney disease (CKD) is common and a major contributor to increased morbidity and early mortality in people with sickle cell anemia (SCA). Urine albumin‐to‐creatinine ratio (uACR) is recommended to identify patients with SCA‐related CKD but its utility in predicting long‐term kidney dysfunction remains unclear in this patient ...
Pablo Bartolucci, Étienne Audureau, Vincent Audard, Frédéric Galactéros, Guillaume Lettre, Charmaine Anthony, Olufolake Egbujo, Jin Han, Maria Armila Ruiz, James P. Lash, Victor R. Gordeuk, Xu Zhang, Santosh L. Saraf   +12 more
wiley   +1 more source

How to delay the progression of chronic kidney disease: focusing on medications [PDF]

Childhood Kidney Diseases
Patients with chronic kidney disease (CKD) bear a significant financial burden and face numerous complications and higher mortality rates. The progression of CKD is associated with glomerular injury caused by glomerular hyperfiltration and oxidative ...
Jeesu Min
doaj   +1 more source

Renal hyperfiltration and systemic blood pressure in patients with uncomplicated type 1 diabetes mellitus. [PDF]

PLoS ONE, 2013
Patients with type 1 diabetes mellitus (DM) and renal hyperfiltration also exhibit systemic microvascular abnormalities, including endothelial dysfunction. The effect of renal hyperfiltration on systemic blood pressure (BP) is less clear.
Gary K Yang, David M Maahs, Bruce A Perkins, David Z I Cherney   +3 more
doaj   +1 more source

Age‐Stratified Associations of Sarcopenic Obesity With Mortality in Type 2 Diabetes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenic obesity, the coexistence of sarcopenia and obesity, has been linked to adverse health outcomes due to comorbidity. Evidence on the association between sarcopenic obesity and mortality among individuals with Type 2 diabetes remains limited Methods Sarcopenic obesity was defined using Japan Working Group on Sarcopenic ...
Shinta Yamamoto, Yoshitaka Hashimoto, Fuyuko Takahashi, Moe Murai, Nozomi Yoshioka, Yuto Saijyo, Chihiro Munekawa, Hanako Nakajima, Noriyuki Kitagawa, Takafumi Osaka, Ryosuke Sakai, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Emi Ushigome, Masahide Hamaguchi, Michiaki Fukui   +16 more
wiley   +1 more source

Diabetes management in maternally inherited diabetes and deafness (MIDD): A review and a proposed treatment algorithm

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 826-839, February 2026.
Abstract Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder usually caused by the variant m.3243A>G in the MT‐TL1 gene. We have proposed that diabetes in MIDD arises from a combination of insulin resistance and impaired β‐cell function that is more likely to occur in the presence of high skeletal muscle heteroplasmy and ...
Ahsen Chaudhry, David M. Thompson, Jean‐Pierre Chanoine   +2 more
wiley   +1 more source

Studies in Zebrafish and Rat Models Support Dual Blockade of EP2 and EP4 (Prostaglandin E ₂ Receptors Type 2 and 4) for Renoprotection in Glomerular Hyperfiltration and Albuminuria [PDF]

, 2023
Aikaterini Kourpa, Angela Schulz, Eva Mangelsen, Debora Kaiser-Graf, Nils Koppers, Monika Stoll, Michael Rothe, Michael Bäder, Bettina Purfürst, Séverine Kunz, Thomas Gladytz, Thoralf Niendorf, Sebastian Bachmann, Kerim Mutig, Juliane Bolbrinker, Daniela Panáková, Reinhold Kreutz   +16 more
openalex   +1 more source

Improving cardiovascular risk stratification through the derivation and validation of an elevated triglyceride‐glucose index

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 982-993, February 2026.
Abstract Background and Aims Triglyceride‐glucose (TyG) index, is an emerging prognostic biomarker in atherosclerotic cardiovascular disease (ASCVD). Validation of its clinical value and of clinically relevant prognostic cut‐off, remains an unmet need to integrate TyG into primary prevention protocols.
Georgios Mavraganis, Georgios Georgiopoulos, Stavros Athanasopoulos, Dimitrios Terentes‐Printzios, Georgios Zervas, Christina Konstantaki, Maria Eleni Koilakou, Sofia‐Panagiota Giannakopoulou, Maria‐Angeliki Dimopoulou, Christina Chrysochoou, Konstantinos Tsioufis, Christos Pitsavos, Evangelos Liberopoulos, Konstantinos Stellos, Charalambos Vlachopoulos, Demosthenes Panagiotakos, Kimon Stamatelopoulos   +16 more
wiley   +1 more source

Glomerular Hyperfiltration in Sickle Cell Disease [PDF]

Clinical Journal of the American Society of Nephrology, 2010
Sickle cell disease (SCD) is a monogenetic, chronic anemia syndrome that is caused by a point mutation in the β-globin gene and affects approximately 100,000 individuals in the United States. Approximately 4 to 5% of these individuals have or will develop stage 5 chronic kidney disease (CKD), and 0.11% of patients who are on long-term maintenance renal
openaire   +1 more source

Tirzepatide and Cardiovascular Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Integrated framework for tirzepatide in HFpEF management. Through metabolic, haemodynamic, structural and anti‐inflammatory pathways, tirzepatide modifies the disease trajectory of HFpEF, leading to improvements in symptoms, functional capacity and reduction in HF events.
Hamza A. Abdul‐Hafez, Ameer Awashra, Sosana Bdir, Sarah Saife, Qasem Salah, Mohammed Barbarawi, Thabet Swaileh, Ahmed Emara, Mohamed S. Elgendy, Abdalhakim Shubietah   +9 more
wiley   +1 more source

Impacts of Diets and Food Plans in Health and Diseases—A Narrative Review

Food Safety and Health, Volume 4, Issue 1, Page 31-49, January 2026.
This review emphasizes different diet types, providing insights into their nutritional content and health effects. Vegetarian and vegan diets, ketogenic diets, Mediterranean diets, Western diets, pescatarian diets, flexitarian diets, and territorial diversified diets are discussed, highlighting their influences on health, and diseases.
Md. Mahbubar Rahman, Manisha Pandit, Bhawana Thukral, Morshed M. Khandoker   +3 more
wiley   +1 more source