Results 91 to 100 of about 16,029 (237)

Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats

Journal of Diabetes Investigation, Volume 16, Issue 7, Page 1232-1242, July 2025.
While SGLT2 accounts for >90% of kidney glucose reabsorption, its pharmacological inhibition or genetic knockdown reduces glucose reabsorption by only 50%. We found that the SGLT2 inhibitor, dapagliflozin, induced an early, transient hyperplastic response in the SGLT1‐expressing S3 segment of the proximal tubule followed by an increase in its length ...
Ellen Wu, Sarah Macklin, Yanling Zhang, Kerri Thai, Linda Nghiem, Caterina Di Ciano‐Oliveira, Nuno Coelho, Hai Wang, Suzanne L. Advani, Jean‐François Desjardins, Darren A Yuen, Paraish Misra, Kim A. Connelly, Jens R. Nyengaard, Richard E. Gilbert   +14 more
wiley   +1 more source

How to delay the progression of chronic kidney disease: focusing on medications [PDF]

Childhood Kidney Diseases
Patients with chronic kidney disease (CKD) bear a significant financial burden and face numerous complications and higher mortality rates. The progression of CKD is associated with glomerular injury caused by glomerular hyperfiltration and oxidative ...
Jeesu Min
doaj   +1 more source

Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease

Cell Death and Disease, 2023
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Glomerular hyperfiltration and albuminuria subject the proximal tubule (PT) to a subsequent elevation of workload, growth, and hypoxia.
Madlen Kunke, Hannah Knöfler, Eileen Dahlke, Luis Zanon Rodriguez, Martina Böttner, Alexey Larionov, Makhabbat Saudenova, Gerrit M. Ohrenschall, Magdalena Westermann, Stefan Porubsky, Joana P. Bernardes, Robert Häsler, Jean-Luc Magnin, Hermann Koepsell, François Jouret, Franziska Theilig   +15 more
doaj   +1 more source

Urinary Peptide Levels in Patients with Chronic Renal Failure [PDF]

, 2010
Introduction: Peptide levels in urine are found to be decreased in renal failure. In the current study urinary peptide levels were determined in chronic renal failure (CRF) patients.
M, Supriya, Mungli, Prakash, Phani, Nagaraj M, R, Kavya   +3 more
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Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]

, 2016
Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji, Imamaki, Hirotaka, Ishii, Akira, Kasahara, Masato, Kuwabara, Takashige, Kuwahara, Koichiro, Mori, Kiyoshi, Mori, Yasuo, Mukoyama, Masashi, Naito, Masaki, Nakao, Kazuwa, Numata, Tomohiro, Ohno, Shoko, Saleem, Moin, Yanagita, Motoko, Yokoi, Hideki   +15 more
core   +3 more sources

Impact of body mass index on the association between kidney function and insulin resistance in diabetic and nondiabetic populations

Journal of Diabetes Investigation, Volume 16, Issue 7, Page 1292-1304, July 2025.
In diabetes with overweight/obesity, eGFR was negatively linearly associated with HOMA‐IR, and creatinine was positively linearly associated with HOMA‐IR. In non‐diabetes with overweight/obesity, the relationship between eGFR and HOMA‐IR was L‐shaped, and the relationship between uric acid and HOMA‐IR was inverted L‐shaped.
Ruo Zhang, Malgorzata A Garstka, Chunhong Zhang, Shimei Ding, Jing Xu   +4 more
wiley   +1 more source

Protein-induced glomerular hyperfiltration: Role of hormonal factors

Kidney International, 1988
High protein diets acutely elevate the glomerular filtration rate. To characterize this response we administered 1 g of protein/kg body weight as a beef steak meal to nine, healthy male subjects and measured glomerular filtration rate (inulin clearance), renal plasma flow (p-amino hippurate clearance), plasma renin activity, aldosterone and plasma and ...
Ellen Miller, Ronald Smith, Glenn C. Newell, Marcia Polansky, Peter S. Heeger, G. Gopal Krishna, Shiv C. Kapoor, Robert D. Hoeldtke   +7 more
openaire   +3 more sources

Unilateral ureteral obstruction in neonatal rats leads to renal insufficiency in adulthood [PDF]

, 2000
Unilateral ureteral obstruction in neonatal rats leads to renal insufficiency in adulthood.BackgroundAlthough unilateral ureteropelvic junction obstruction is the most common cause of congenital obstructive nephropathy in infants and children, management
Chang, Alice Y., Chevalier, Robert L., Thornhill, Barbara A.   +2 more
core   +1 more source

A Mendelian randomization study on the causal association of circulating cytokines with diabetic nephropathy

Journal of Diabetes Investigation, Volume 16, Issue 7, Page 1274-1283, July 2025.
We performed a two‐sample MR analysis to investigate the causal relationship between circulating cytokines and DN in individuals of European ancestry. We found evidence to support the causal role of genetically predicted circulating levels on the increased risk of DN, including interferon‐gamma, stem cell factor, and stromal‐cell‐derived factor 1 alpha,
Yiming Xu, Tian Xiao, Junqing Yang, Jiali Wang, Bingting Wang, Chen Qiao   +5 more
wiley   +1 more source

Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship [PDF]

, 2018
Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated.
Agüero, Rocio, Ezquer, Eduardo Marcelo, Ezquer, Fernando, Fader Kaiser, Claudio Marcelo, Giraud Billoud, Maximiliano German   +4 more
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