Results 111 to 120 of about 16,029 (237)

Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks

Diabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 2920-2939, June 2025.
Abstract Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While insulin deficiency is the key mechanism for hyperglycaemia in T1D, individuals with this condition can also develop insulin resistance (IR), making ...
Ahmad M. Rajab, Sam Pearson, Ramzi A. Ajjan   +2 more
wiley   +1 more source

Determination of the best method to estimate glomerular filtration rate from serum creatinine in adult patients with sickle cell disease: a prospective observational cohort study

BMC Nephrology, 2012
Background Sickle cell disease (SCD) leads to tissue hypoxia resulting in chronic organ dysfunction including SCD associated nephropathy. The goal of our study was to determine the best equation to estimate glomerular filtration rate (GFR) in SCD adult ...
Arlet Jean-Benoît, Ribeil Jean-Antoine, Chatellier Gilles, Eladari Dominique, De Seigneux Sophie, Souberbielle Jean-Claude, Friedlander Gérard, de Montalembert Marianne, Pouchot Jacques, Prié Dominique, Courbebaisse Marie   +10 more
doaj   +1 more source

Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E₂ Activation in Human Podocytes

Cells, 2020
Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman’s space.
Eva Mangelsen, Michael Rothe, Angela Schulz, Aikaterini Kourpa, Daniela Panáková, Reinhold Kreutz, Juliane Bolbrinker   +6 more
doaj   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

The ‘nephrotoxins’ were stopped: what is in a name and its impact on kidney and cardiac health?

Internal Medicine Journal, Volume 55, Issue 6, Page 1037-1041, June 2025.
Abstract The term ‘nephrotoxin’ is often imprecisely applied to medications that are not inherently toxic to the kidneys, including renin‐angiotensin‐aldosterone system inhibitors, sodium‐glucose co‐transporter 2 inhibitors, diuretics and metformin. These drugs are frequently included in ‘sick day rules’ and may be prematurely discontinued during acute
Catherine Mao, Bobby Chacko
wiley   +1 more source

Gambaran eGFR Menurut CKD-EPI pada Penderita Thalassemia Mayor di Rumah Sakit Dr. Hasan Sadikin Bandung

Majalah Kedokteran Bandung, 2017
Increased life expectancy of thalassemia patients has a consequence of various manifestations of the diseases in many organs including kidney. Estimated glomerular filtration rate (eGFR) can be used for detecting early renal dysfunctions due to the fact ...
Rismauli Doloksaribu, Rizka Husna, Amaylia Oehadian   +2 more
doaj   +1 more source

Relevance of single nephron studies to human glomerular function [PDF]

, 1994
Over the past decades, the search for clues to the understanding of renal function and disease has led to the ongoing development of innovative laboratory techniques to approach these questions on the single nephron level.
Anderson, Sharon
core   +1 more source

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

Mind the gap: connexins and cell–cell communication in the diabetic kidney [PDF]

, 2015
Connexins, assembled as a hexameric connexon, form a transmembrane hemichannel that provides a conduit for paracrine signalling of small molecules and ions to regulate the activity and function of adjacent cells.
A Abed, A Awad, A Cove-Smith, A Kurtz, A Mendoza-Naranjo, A Pfenniger, A Sipos, AF Li, AF Li, BN Giepmans, C Qiu, C Wagner, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, Claire E. Hills, CM Wang, CS Wright, D Bosco, D Lu, DW Laird, E Yaoita, F Hanner, F Mumtaz, G Sahu, Gareth W. Price, GS Goldberg, GS Hillis, GS Hillis, I Loeffler, J Gilleron, J Kronengold, J Wada, J Yao, J Yao, J Yao, J Zhang, JA Haefliger, JA Haefliger, JA Wright, JC Herve, JH Zhang, K Fujimoto, K Sawai, L Gal Le, L Liu, M Dalla Vestra, M Firouzi, M Gerl, M Oppermann, M Oyamada, MA Retamal, MS Nielsen, MW Bobbie, N Defamie, N Krattinger, N Wang, P Svenningsen, Paul E. Squires, PD Lampe, Q Yan, R Hernández-Salinas, R Hirschberg, RM Mege, S Tsuchida, SP Prabhakar, SS Prabhakar, T Inoguchi, T Morioka, T Sato, T Takenaka, T Takenaka, T Tien, WM Jongen, X Xie, X Zhang, Y Liu, Y Suzaki, YC Lee   +82 more
core   +1 more source

Nierenfunktion und nephronsparende Operationstechnik: Nephrologische Sicht [PDF]

, 2008
Das Nierenzellkarzinom ist ein häufiger Tumor, welcher mit zunehmendem Alter vor allem bei Männern auftritt. Eine steigende Inzidenz wird in den letzten Jahren festgestellt, vor allem wegen der Zunahme von radiologischen Untersuchungen, im Rahmen ...
Wüthrich, R P
core   +2 more sources