Results 171 to 180 of about 169,139 (203)

Glomerular hyperfiltration in morbid obesity: Role of the inflammasome signalling

Nephrology, 2022
Obesity is associated with glomerular hyperfiltration which may precede the development of overt renal damage. Few studies evaluated the link between inflammasome signalling and hyperfiltration.
D. Moriconi, L. Antonioli, S. Masi, R. Bellini, C. Pellegrini, E. Rebelos, S. Taddei, M. Nannipieri   +7 more
semanticscholar   +1 more source

Insulin Resistance Associated with Clinical Manifestations of Diabetic Kidney Disease (Glomerular Hyperfiltration, Albuminuria, and Kidney Function Decline).

Current Diabetes Reviews, 2021
Clinical features of diabetic kidney disease include glomerular hyperfiltration, albuminuria, and kidney function decline towards End-Stage Kidney Disease (ESKD).
María M. Adeva-Andany, C. Fernández-Fernández, R. Funcasta-Calderón, E. Ameneiros-Rodríguez, Lucía Adeva-Contreras, E. Castro-Quintela   +5 more
semanticscholar   +1 more source

SGLT2 Inhibitors in Glomerular Hyperfiltration

Case Medical Research, 2019

semanticscholar   +2 more sources

Development of glomerular hyperfiltration, a multiphasic phenomenon

American Journal of Physiology-Renal Physiology, 2020
The trajectory of glomerular filtration rate (GFR) in relation to glomerular hyperfiltration (GHF) has been unknown. It was evaluated retrospectively in 23,982 GHF-free health examinees who were followed for 2−10 yr (mean: 5.1 yr). GFR was estimated by the serum creatinine concentration, and GHF was defined as age- and sex-specific estimated GFR (eGFR)
Yasuho Shimada, Yasuto Nakasone, Kazuko Hirabayashi, Takahiro Sakuma, Hideo Koike, Tomomasa Oguchi, Koh Yamashita, Ryo Uchimido, Tatsumi Moriya, Mitsuhisa Komatsu, Toru Aizawa   +10 more
openaire   +2 more sources

Glomerular Hyperfiltration in Human Diabetes

Diabetes Care, 1994
The presence of the characteristic early glomerular hyperfiltration seenin diabetes was originally suggested long ago by Cambier (1), indeed a few years before the well-known studies by Kimmelstiel and Wilson (2) that documented the typical glomerular structural lesions in diabetic patients. Brenner (3,4), in his breakthrough glomerular hyperfiltration-
openaire   +2 more sources

Glomerular hyperfiltration: definitions, mechanisms and clinical implications

Nature Reviews Nephrology, 2012
Glomerular hyperfiltration is a phenomenon that can occur in various clinical conditions including kidney disease. No single definition of glomerular hyperfiltration has been agreed upon, and the pathophysiological mechanisms, which are likely to vary with the underlying disease, are not well explored.
Imed, Helal, Godela M, Fick-Brosnahan, Berenice, Reed-Gitomer, Robert W, Schrier   +3 more
openaire   +2 more sources

Kinin, a Mediator of Diabetes-Induced Glomerular Hyperfiltration

Diabetes, 1995
Renal kallikrein is increased in diabetic patients and streptozotocin (STZ)-induced diabetic rats with hyperflltration. Chronic inhibition of renal kallikrein reduces glomerular filtration rate (GFR) and renal plasma flow (RPF) in hyperfiltering STZ-induced diabetic rats.
A A, Jaffa, P F, Rust, R K, Mayfield
openaire   +2 more sources

Acute intrarenal angiotensin (1‐7) infusion decreases diabetes‐induced glomerular hyperfiltration but increases kidney oxygen consumption in the rat

Acta Physiologica, 2019
Common kidney alterations early after the onset of insulinopenic diabetes include glomerular hyperfiltration, increased oxygen consumption and tissue hypoxia.
Patrik Persson, A. Fasching, F. Palm
semanticscholar   +1 more source

Enalapril Attenuates Glomerular Hyperfiltration following a Meat Meal

Nephron, 1989
It has been shown that the glomerular filtration rate increases after a meat meal. We examined in humans whether enalapril, which has been shown to decrease glomerular capillary pressure in rats with chronic renal failure, could attenuate the renal response to a meat meal. Twelve healthy volunteers were studied after an oral protein load, 1.5 g/kg body
A, Chagnac, U, Gafter, D, Zevin, Y, Hirsch, I, Markovitz, J, Levi   +5 more
openaire   +2 more sources

Abnormalities of Glomerular Eicosanoid Metabolism in States of Glomerular Hyperfiltration

1989
The glomerulus is a complex structure that functions primarily to produce an ultrafiltrate of plasma. Micropuncture studies in the Munich-Wistar rat have identified the major physical determinants of the glomerular filtration rate (GFR): glomerular plasma flow; afferent protein concentration; transcapillary hydraulic-pressure difference; and the ...
M, Schambelan, B R, Don, G A, Kaysen, S, Blake   +3 more
openaire   +2 more sources