Results 31 to 40 of about 169,139 (203)

Paradigm Shift in Hyperglycemic Glomerular Hyperfiltration: Blunted Tubuloglomerular Feedback or Preglomerular Vasodilation? [PDF]

Hypertension, 2023
Wu J.
europepmc   +3 more sources

Molecular programs associated with glomerular hyperfiltration in early diabetic kidney disease. [PDF]

Kidney Int, 2022
Stefansson VTN, Nair V, Melsom T, Looker HC, Mariani LH, Fermin D, Eichinger F, Menon R, Subramanian L, Ladd P, Harned R, Harder JL, Hodgin JB, Bjornstad P, Nelson PJ, Eriksen BO, Nelson RG, Kretzler M.   +17 more
europepmc   +2 more sources

High-Protein Diet-Induced Glomerular Hyperfiltration Is Dependent on Neuronal Nitric Oxide Synthase β in the Macula Densa via Tubuloglomerular Feedback Response. [PDF]

Hypertension, 2019
It is well known that high protein intake increases glomerular filtration rate. Evidence from several studies indicated that NO and tubuloglomerular feedback (TGF) mediate the effect.
Wei J, Zhang J, Jiang S, Wang L, Persson AEG, Liu R.   +5 more
europepmc   +2 more sources

Tissue lipidomic profiling supports a mechanistic role of the prostaglandin E2 pathway for albuminuria development in glomerular hyperfiltration. [PDF]

Front Netw Physiol, 2023
Kaiser-Graf D, Schulz A, Mangelsen E, Rothe M, Bolbrinker J, Kreutz R.   +5 more
europepmc   +3 more sources

Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia.

J Am Soc Nephrol, 2019
BACKGROUND Glomerular hyperfiltration is common in early diabetes and is considered a risk factor for later diabetic nephropathy. We propose that sodium-glucose cotransporter 1 (SGLT1) senses increases in luminal glucose at the macula densa, enhancing ...
Zhang J, Wei J, Jiang S, Xu L, Wang L, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R.   +9 more
europepmc   +2 more sources

New insights on glomerular hyperfiltration: a Japanese autopsy study. [PDF]

JCI Insight, 2017
It has been suggested that low nephron number contributes to glomerular hypertension and hyperperfusion injury in progressive chronic kidney disease (CKD).
Kanzaki G, Puelles VG, Cullen-McEwen LA, Hoy WE, Okabayashi Y, Tsuboi N, Shimizu A, Denton KM, Hughson MD, Yokoo T, Bertram JF.   +10 more
europepmc   +2 more sources

Long-term prospective observation suggests that glomerular hyperfiltration is associated with rapid decline in renal filtration function: A multiethnic study [PDF]

Diabetes & vascular disease research, 2018
Aim: Glomerular hyperfiltration usually occurs early in development of kidney complications in diabetes. To understand hyperfiltration as a marker of renal disease progression in type 2 diabetes mellitus, we aimed to examine association between ...
Serena Low, Xiao Zhang, Jiexun Wang, Lee Ying Yeoh, Allen Yan Lun Liu, Keven Ang, Wern Ee Tang, Pek Yee Kwan, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim   +10 more
openalex   +2 more sources

Knockout of Na⁺-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration.

Am J Physiol Renal Physiol, 2019
The Na-glucose-cotransporter SGLT1 mediates glucose reabsorption in late proximal tubules. SGLT1 also mediates macula densa-sensing of an increase in luminal glucose, which increases nitric oxide synthase-1 (MD-NOS1)-mediated NO formation and potentially
Song P, Huang W, Onishi A, Patel R, Kim YC, van Ginkel C, Fu Y, Freeman B, Koepsell H, Thomson S, Liu R, Vallon V.   +11 more
europepmc   +2 more sources

Renal hyperfiltration defined by high estimated glomerular filtration rate: A risk factor for cardiovascular disease and mortality [PDF]

Diabetes, obesity and metabolism, 2019
Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes.
Mehmet Kanbay, Lale A. Ertuğlu, Barış Afşar, Elif Ozdogan, Zeynep S. Kucuksumer, Alberto Ortíz, Adrian Covic, Masanari Kuwabara, David Z.I. Cherney, Daniël H. van Raalte, Dick de Zeeuw   +10 more
openalex   +2 more sources

Is there an association between glomerular hyperfiltration and coronary flow velocity reserve in patients with gestational diabetes history? [PDF]

Biomol Biomed
Takir M, Telci Caklili O, Betul Ozcan F, Atici A, Caliskan M.   +4 more
europepmc   +3 more sources