Results 51 to 60 of about 169,139 (203)

Glomerular hyperfiltration in prediabetes and prehypertension [PDF]

Nephrology Dialysis Transplantation, 2011
This study aimed to investigate the associations of hyperfiltration and hypofiltration with prediabetes and prehypertension.The study subjects included 99 140 people aged 20-89 years who underwent health checkups in Aichi Prefecture, Japan. The prevalence of hyperfiltration [estimated glomerular filtration rate (eGFR) above the age-/sex-specific 95th ...
Rieko, Okada, Yoshinari, Yasuda, Kazuyo, Tsushita, Kenji, Wakai, Nobuyuki, Hamajima, Seiichi, Matsuo   +5 more
openaire   +2 more sources

Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models

Frontiers in Pharmacology, 2021
Large-scale clinical outcome studies demonstrated the efficacy of SGLT2 inhibitors in patients with type II diabetes. Besides their therapeutic efficacy in diabetes, significant renoprotection was observed in non-diabetic patients with chronic kidney ...
Philipp Tauber, Frederick Sinha, Raffaela S. Berger, Wolfram Gronwald, Katja Dettmer, Michaela Kuhn, Maximilian Trum, Lars S. Maier, Stefan Wagner, Frank Schweda   +9 more
doaj   +1 more source

Glomerular Hyperfiltration in Hypertensive African Americans [PDF]

Hypertension, 2000
Abstract —The incidence of end-stage renal disease attributable to hypertension is 5-fold greater in African Americans than in whites. To determine whether glomerular hyperfiltration is an antecedent to renal failure, we compared responses of renal blood flow and glomerular filtration rate to graded infusions of ...
T A, Kotchen, A W, Piering, A W, Cowley, C E, Grim, D, Gaudet, P, Hamet, M L, Kaldunski, J M, Kotchen, R J, Roman   +8 more
openaire   +2 more sources

Glomerular Biomechanical Stress and Lipid Mediators during Cellular Changes Leading to Chronic Kidney Disease

Biomedicines, 2022
Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD).
Mukut Sharma, Vikas Singh, Ram Sharma, Arnav Koul, Ellen T. McCarthy, Virginia J. Savin, Trupti Joshi, Tarak Srivastava   +7 more
doaj   +1 more source

Proximal tubular hypertrophy and enlarged glomerular and proximal tubular urinary space in obese subjects with proteinuria. [PDF]

PLoS ONE, 2013
BACKGROUND: Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy.
Ana Tobar, Yaacov Ori, Sydney Benchetrit, Gai Milo, Michal Herman-Edelstein, Boris Zingerman, Netta Lev, Uzi Gafter, Avry Chagnac   +8 more
doaj   +1 more source

Glomerular hyperfiltration: A new marker of metabolic risk [PDF]

Kidney International, 2007
Chronic kidney disease coexists with metabolic syndrome and this relationship may be apparent before overt manifestations of cardiovascular disease. To investigate early stages of the natural history of associations between renal function and metabolic syndrome, we phenotyped 1572 young (mean age=18.4 years), apparently healthy men for metabolic risk ...
Tomaszewski, Maciej, Charchar, Fadi J., Maric, Christine, McClure, John, Crawford, Lynne, Grzeszczak, Wladyslaw, Sattar, Naveed, Zukowska-Szczechowska, Ewa, Dominiczak, Anna F.   +8 more
openaire   +3 more sources

Renal Glomerular Hyperfiltration is Associated with Poor Prognosis in Acute ST-Elevation Myocardial Infarction

İstanbul Medical Journal, 2021
Introduction:Glomerular hyperfiltration is related to several clinical conditions, such as prediabetes and prehypertension, and associated with poor prognosis in long-term follow-up.
Ahmet Zengin, Mehmet Baran Karataş, Yiğit Çanga, Gündüz Durmuş, Özge Güzelburç, Nizamettin Selçuk Yelgeç, Ayşe Emre   +6 more
doaj   +1 more source

Case report: increased single-nephron estimated glomerular filtration rate in an adult patient with low birth weight

BMC Nephrology, 2020
Background Low birth weight (LBW) is associated with end-stage kidney disease and hypertension and is considered to be a surrogate marker of low nephron number. Low nephron number is hypothesized to contribute to glomerular hyperfiltration that may cause
Yuriko Shiozaki, Tomoyuki Fujikura, Shinsuke Isobe, Ibuki Takatsuka, Taichi Sato, Daiki Goto, Sayaka Ishigaki, Naro Ohashi, Hideo Yasuda   +8 more
doaj   +1 more source

Acute kidney injury urinary biomarker time-courses. [PDF]

PLoS ONE, 2014
Factors which modify the excretion profiles of acute kidney injury biomarkers are difficult to measure. To facilitate biomarker choice and interpretation we modelled key modifying factors: extent of hyperfiltration or reduced glomerular filtration rate ...
John W Pickering, Zoltán H Endre
doaj   +1 more source

Insulin resistance underlies the elevated cardiovascular risk associated with kidney disease and glomerular hyperfiltration.

Reviews in cardiovascular medicine, 2020
The curve that describes the relationship between glomerular filtration rate (GFR) and cardiovascular risk is U-shaped, indicating that both reduced GFR (kidney failure) and elevated GFR (glomerular hyperfiltration) are equivalent cardiovascular risk ...
María M. Adeva-Andany, C. Fernández-Fernández, Natalia Carneiro-Freire, E. Castro-Quintela, A. Pedre-Piñeiro, Mónica Seco-Filgueira   +5 more
semanticscholar   +1 more source