Results 61 to 70 of about 169,139 (203)
Tubular reabsorption and diabetes‐induced glomerular hyperfiltration [PDF]
Acta Physiologica, 2010 AbstractElevated glomerular filtration rate (GFR) is a common observation in early diabetes mellitus and closely correlates with the progression of diabetic nephropathy. Hyperfiltration has been explained to be the result of a reduced load of sodium and chloride passing macula densa, secondarily to an increased proximal reabsorption of glucose and ...
P, Persson, P, Hansell, F, Palm
openaire +2 more sources
Nephron, 2019 Background: Glomerular hyperfiltration (GH) is a hallmark of renal dysfunction in diabetes and obesity. Recent clinical trials demonstrated that SGLT2 inhibitors are renoprotective, possibly by abating hyperfiltration.
A. Chagnac +3 more
semanticscholar +1 more source
Biomarker Insights, 2021 Introduction: The kidney deterioration, which starts in childhood often leads to end-stage renal failure in the future. Therefore, searching for an early, sensitive, and specific biomarkers became a paramount for chronic kidney disease diagnosis. The aim
Agata Będzichowska +4 more
doaj +1 more source
Diabetic Proteinuria Revisited: Updated Physiologic Perspectives
Cells, 2022 Albuminuria, a hallmark of diabetic nephropathy, reflects not only injury and dysfunction of the filtration apparatus, but is also affected by altered glomerular hemodynamics and hyperfiltration, as well as by the inability of renal tubular cells to ...
Samuel N. Heyman +5 more
doaj +1 more source
Glomerular Hyperfiltration in Hypertensive Fawn-Hooded Rats
Kidney and Blood Pressure Research, 1988 The glomerular filtration rate (GFR), effective renal plasma flow (ERPF), systolic blood pressure (SBP) and urinary protein excretion (U<sub>P</sub>V) were determined in 12-week-old male rats of the spontaneously hypertensive Fawn-Hooded (FH) strain.
M H, de Keijzer +2 more
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Glomerular Hyperfiltration and Albuminuria in Critically ILL Patients [PDF]
Anaesthesia and Intensive Care, 2008 Glomerular hyperfiltration and albuminuria are two pathological conditions that could alter renal drug elimination, but they have been rarely studied in a critical care setting. The aims of this descriptive, prospective study performed on 89 critically ill patients are to determine rates of glomerular hyperfiltration (main objective) and albuminuria (
O, Fuster-Lluch +3 more
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Revista Brasileira de Hematologia e Hemoterapia, 2013 BACKGROUND Renal failure is common among older patients with sickle cell disease; this is preceded by subclinical glomerular hyperfiltration. Data about renal function of adults with sickle cell disease have been reported, but data on children is scarce,
Rafael Pereira de Paula +4 more
doaj +1 more source
BMC Nephrology, 2023 Background The relationship between obesity and nonalcoholic fatty liver disease and renal hyperfiltration is controversial. This study aimed to assess the correlations of body mass index and fatty liver index, respectively, with renal hyperfiltration in
Atsushi Kitazawa, Yoshiharu Fukuda
doaj +1 more source
Treatable glomerular hyperfiltration in patients with active acromegaly [PDF]
European Journal of Endocrinology, 2016 ObjectiveThe glomerular filtration rate (GFR) is increased in patients with active acromegaly. The aim of this study is to elucidate whether renal function deteriorates in patients with acromegaly and whether this deterioration is reversible after surgical remission.Design/methodsA case–control study of 48 acromegalic patients who were surgically cured
Shingo, Fujio +10 more
openaire +2 more sources
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source