Results 81 to 90 of about 169,139 (203)
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Sotagliflozin, an inhibitor of sodium‐glucose co‐transporter (SGLT)‐1 and 2, reduces albuminuria, slows GFR decline, and may have diuretic and osmoregulatory effects. The effect of sotagliflozin added to insulin was assessed on markers of neurohormone activation and volume homeostasis in patients with type 1 diabetes (T1D).
Massimo Nardone +6 more
wiley +1 more source
Associations between renal hyperfiltration and serum alkaline phosphatase. [PDF]
PLoS ONE, 2015 Renal hyperfiltration, which is associated with renal injury, occurs in diabetic or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary excretion of ...
Se Won Oh, Kum Hyun Han, Sang Youb Han
doaj +1 more source
[Glomerular hyperfiltration and diabetic nephropathy].
Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2012 Changes in renal microcirculation represent the important factor in the progression of cardiovascular and renal complications. Microalbuminuria is the earliest indication that indicates the kidney and systemic microcirculatory disorder. the importance of microalbuminuria as a risk factor of increased cardiovascular mortality is well documented.
PRKAČIN, INGRID, BULUM, TOMISLAV
openaire +3 more sources
The biology of PKM2 in the metabolism and senescence in diabetic kidney disease
Journal of Diabetes Investigation, EarlyView.ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from normal oxidative phosphorylation toward glycolysis.
Md. Imrul Kayes, Keizo Kanasaki
wiley +1 more source
Kidney Hyperfiltration After Nephrectomy: A Mechanism to Restore Kidney Function in Living Donors
Acta Medica Indonesiana, 2020 Living donor kidney transplantation (LDKT) is the treatment of choice for patients with end stage renal disease (ESRD). Up to now, the studies reporting the impact of nephrectomy in living kidney donors to their future kidney function were limited. Most
Maruhum Bonar Marbun, Endang Susalit
doaj +2 more sources
Glomerular Hyperfiltration in Experimental Diabetes Mellitus [PDF]
Journal of the American Society of Nephrology, 1999 Abstract. An increase in Na+/glucose cotransport upstream to the macula densa might contribute to the increase in single nephron GFR (SNGFR) in early diabetes mellitus by lowering the signal of the tubuloglomerular feedback, i.e., the luminal Na+, Cl-, and K+ concentration sensed by the macula densa.
V, Vallon +4 more
openaire +2 more sources
Experimental Physiology, EarlyView.Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal +9 more
wiley +1 more source
Rheological Influence Upon the Glomerular Podocyte and Resultant Mechanotransduction
Kidney & Blood Pressure Research, 2015 The glomerular podocyte is exposed to numerous mechanical forces as a constituent of the glomerular filtration apparatus. This includes fluid shear stress (FSS) displaced upon the podocytic foot process's apical, lateral, and basal surfaces.
Simona Pichler Sekulic, Miroslav Sekulic
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Obesity Science & Practice, 2019 Summary Objective Determine prevalence of hyperfiltration (high estimated glomerular filtration rate "eGFR" >95th percentile for age/sex) among youth and association with BMI classification.
Christy B. Turer +4 more
doaj +1 more source
Glycemia affects glomerular filtration rate in people with type 2 diabetes
BMC Nephrology, 2019 Background In type 2 diabetes (T2DM), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) systematically underestimates the measured adjusted glomerular filtration rate (aGFR) when aGFR
E. Jennifer Weil +3 more
doaj +1 more source