Results 41 to 50 of about 5,449 (282)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Effects of sifferent levels of preharvest shading on the storage quality of strawberry (Fragariax ananassa Duchesne) cv. Ostara I. physical characteristics [PDF]

open access: yes, 1994
The effects of shading developing fruits up to harvest on strawberry (Fragaria X ananassa Duchesne) cv. 'Ostara ' fruit quality were studied. Plants were shaded with netting of different levels of light penetration (74,58, 48,38 and 5% which are ...
Osman, Azizah, Peter B., Dodd
core  

Avenue Literair: literatuur in de ‘glossy-aller-glossy’s’, 1967-1990 [PDF]

open access: yesTijdschrift voor Tijdschriftstudies, 2011
The glossy magazine Avenue (1965-1994) is famous for its pioneering combination of words and images. The luxuriously designed magazine successfully combined lifestyle topics with art and design. Little is known about the magazine's literary supplement, Avenue Literair (1967-1990).
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Increasing the Complexity of the Illumination May Reduce Gloss Constancy

open access: yesi-Perception, 2017
We examined in which way gradual changes in the geometric structure of the illumination affect the perceived glossiness of a surface. The test stimuli were computer-generated three-dimensional scenes with a single test object that was illuminated by ...
Gunnar Wendt, Franz Faul
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Can Color and Motion Information Be Used to Disentangle the Influence of Multiple Light Sources on Gloss Perception?

open access: yesi-Perception, 2018
Previous results suggest that the glossiness of a surface is systematically underestimated when adjacent highlights from different light sources overlap to such an extent that they appear as a single, expanded highlight.
Gunnar Wendt, Franz Faul
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

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