Results 111 to 120 of about 125,339 (239)

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Intestinal interleukin-22 enhances GLP-1 production via the STAT3 pathway to improve glucose homeostasis during high-fat diet induced obesity in a study with male mice

Nature Communications
Metabolic disorders such as obesity and diabetes are influenced by glucagon-like peptide-1 (GLP-1), which regulates insulin secretion. Interleukin (IL)−22 maintains intestinal barrier function, yet its role in metabolic regulation remains unclear.
Chae-Won Kim, Jae-Hee Ahn, Bo Ra Lee, Hong Min Kim, Youngjoo Han, Jae-Hyeon Jeong, Jaewon Cho, Hyunjin Jeong, Dae-Joon Kim, Seong-Eun Kim, Jeon-Kyung Kim, Yu-Bin Lee, Su Min Kim, Hye Hyun Yoo, Eun Hye Lee, Su Ryeon Seo, Kyung Bong Ha, Eun Soo Lee, Mi-Na Kweon, Hong Pyo Kim, Sun-Young Chang, Choon Hee Chung, Hyun-Jeong Ko   +22 more
doaj   +1 more source

Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation

Biomolecules
Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are related intestinal L-cell derived secretory products. GLP-1 has been extensively studied in terms of its influence on metabolism, but less attention has been devoted to GLP-2 in this
Asif Ali, Dawood Khan, Vaibhav Dubey, Andrei I. Tarasov, Peter R. Flatt, Nigel Irwin   +5 more
doaj   +1 more source

From Stakeholder Pressure to Strategic Advantage: A Framework of Achieving Environment Sustainability Through Pathway of Carbon Neutrality

Business Strategy and the Environment, EarlyView.
ABSTRACT Businesses are increasingly striving to reduce their carbon footprint, with carbon offsetting emerging as a viable pathway towards achieving carbon neutrality. Such efforts signify a demonstrated commitment to fostering environmental sustainability and contributing to a more sustainable future.
Sanjeev Yadav, Ashutosh Samadhiya, Anil Kumar, Sunil Luthra, Krishan Kumar Pandey   +4 more
wiley   +1 more source

Serum levels of glucagon-like peptide (GLP)-1 and GLP-2 in patients with Hashimoto′s thyroiditis

Journal of Research in Medical Sciences, 2015
Background: The influence of Hashimoto′s thyroiditis (HT) with subclinical hypothyroidism or euthyroid status on the alteration of glucagon-like peptide (GLP)-1 and GLP-2 levels remains uncertain.
Yue Jin, Hong Liu, Shao-Gang Ma, Jian-Ping Cheng, Kai Zhang   +4 more
doaj  

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Poster 6: GLP-1 Receptor Agonist Use Is Not Associated With an Increased Risk of Complications After Anatomic Total Shoulder Arthroplasty

Orthopaedic Journal of Sports Medicine
Objectives: Glucagon-like-peptide-1 (GLP-1) agonists, also known as GLP-1 receptor agonists (GLP-1 RAs), incretin mimetics, or GLP-1 analogs are a class of medications that have surged in popularity since their approval.
Arsen M. Omurzakov BA, Arsen M. Omurzakov BA, Aakash Shah, David C. Kaelber, John M. Apostolakos   +4 more
doaj   +1 more source

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, EarlyView.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Engineering Biochar‐Derived Functional Materials for High‐Performance Supercapacitors: Design Principles, Mechanisms, and Scalable Strategies

Carbon Energy, EarlyView.
ABSTRACT Biochar has emerged as a useful and adaptable source of carbon for supercapacitor electrodes. Its value comes from the way biomass chemistry, thermal conversion, and activation conditions shape the resulting pore network, surface groups, and degree of carbon ordering.
Soumen Mandal, Avinash C. Mendhe, Mayna Roy, Neha S. Barse, Taejoon Park, Han‐Seung Lee, Haigun Lee   +6 more
wiley   +1 more source

Sustainable Synthesis of 4,7‐Dihydro‐4,7‐ethano‐2H‐isoindoles—Key Building Blocks to Benzoporphyrins

Chemistry – A European Journal, EarlyView.
A facile and sustainable route to isoindole derivatives—key benzoporphyrin precursors—brings high‐ and low‐symmetry benzoporphyrins closer to practical application. ABSTRACT Benzoporphyrins, π extended porphyrin analogues, exhibit remarkable potential for optoelectronic and theragnostic applications, yet have remained largely confined to fundamental ...
Lampros Pascal Gazetas, Michael Ruppel, Christoph Richtzenhain, Frank Hampel, Norbert Jux, Dominik Lungerich   +5 more
wiley   +1 more source