Results 1 to 10 of about 123,474 (139)

GLP-1 RAs for Treating Metabolic Dysfunction-Associated Steatosis Liver Disease: From GLP-1 Discovery to FDA Approval: A Comprehensive Narrative Review [PDF]

Pharmaceuticals
Background: Metabolic dysfunction-associated steatosis liver disease (MASLD), formerly termed nonalcoholic fatty liver disease (NAFLD), has emerged as the most prevalent cause of chronic liver disease worldwide.
Olfa Khalifa, Abdelilah Arredouani
doaj   +2 more sources

Beyond GLP‐1 [PDF]

Journal of Diabetes
Zachary Bloomgarden
doaj   +2 more sources

An Update on GLP‐1 Receptor Agonists [PDF]

Journal of Diabetes
Zachary Bloomgarden
doaj   +2 more sources

Age and Gender Effects on Genotoxicity in Diesel Exhaust Particles Exposed C57BL/6 Mice

Biomolecules, 2021
There is growing evidence that the accumulation of DNA damage induced by fine particulate matter (PM2.5) exposure is an underlying mechanism of pulmonary disease onset and progression.
Joong Won Lee, Jin Sik Kim, Hee Jae Lee, Ji-Hye Jang, Ja-Hyun Kim, Woo Jong Sim, Yong-beom Lim, Ji-Won Jung, Hyun Joung Lim   +8 more
doaj   +1 more source

Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms [PDF]

, 2013
Background:Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy.
A Aneja, S Chen, K Mizushige, DJ Drucker, LA Nikolaidis, GG Sokos, K Ban, S Mudaliar, H Hui, DA Glauser, K-D Wagner, H Zhang, C-G Ostenson, A Tahara, C Orskov, EM Escudero, S Ravassa, WC Claycomb, R Martín, F Strutz, DLM Hickson-Bick, Y Ishibashi, S Ares-Carrasco, S Dhillon, S Mojsov, Y Ye, P Anagnostis, MH Noyan-Ashraf, W Yan, M Rajesh, S Ares-Carrasco, A D’Souza, BH Lorell, TJ Regan, M Lenski, M Rendell, J Rosenstock, G Mellitzer, M Cobble, M Sauvé, Y Ishibashi, A Mima, PA Read, R Gros, E Tomas, X-F Wang, H Xiao, T Okerson, H Oeseburg, KA Burns, N Wagner, SC Fan, HJ Kim, S Piteau   +53 more
core   +20 more sources

Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets [PDF]

, 2020
Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake.
Davis, Dawn, de Souza, Arnaldo Henrique, Kibbe, Carly R., Linnemann, Amelia K., Merrins, Matthew J., Saghafi, Samuel T., Tang, Jiayin, Yadev, Amanjot Kaur   +7 more
core   +1 more source

Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. [PDF]

PLoS ONE, 2013
Glucagon-like-peptide-1 (GLP-1) is a gut- and neuro-peptide with an important role in the regulation of food intake and glucose metabolism. Interestingly, GLP-1 receptors (GLP-1R) are expressed in key mesolimbic reward areas (including the ventral ...
Rozita H Shirazi, Suzanne L Dickson, Karolina P Skibicka   +2 more
doaj   +1 more source

Novel GLP-1 fusion chimera as potent long acting GLP-1 receptor agonist. [PDF]

PLoS ONE, 2010
GLP-1 has a variety of anti-diabetic effects. However, native GLP-1 is not suitable for therapy of diabetes due to its short half-life (t1/2168 h. Intraperitoneal glucose tolerance test (IPGTT) in mice showed that GLP-1/hIgG2 significantly decreased ...
Qinghua Wang, Kui Chen, Rui Liu, Fang Zhao, Sandeep Gupta, Nina Zhang, Gerald J Prud'homme   +6 more
doaj   +1 more source

Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists

Pharmaceuticals, 2022
Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes.
Lei Sun, Zhi-Ming Zheng, Chang-Sheng Shao, Zhi-Yong Zhang, Ming-Wei Li, Li Wang, Han Wang, Gen-Hai Zhao, Peng Wang   +8 more
doaj   +1 more source

Brain Endothelial Cells Regulate Glucagon-Like Peptide 1 Entry Into the Brain via a Receptor-Mediated Process

Frontiers in Physiology, 2020
Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects.
Zhuo Fu, Liying Gong, Liying Gong, Jia Liu, Jing Wu, Jing Wu, Eugene J. Barrett, Kevin W. Aylor, Zhenqi Liu   +8 more
doaj   +1 more source