High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena +7 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley +1 more source
Weight Loss Intentionality and Strategies in Urinary Incontinence
Neurourology and Urodynamics, EarlyView.ABSTRACT Introduction Urinary incontinence (UI)−including stress (SUI), urge (UUI), and mixed (MUI) subtypes−is associated with obesity, and weight loss is commonly recommended for intervention. However, the comparative effects of intentionality and weight loss strategies on UI severity remain poorly defined.
Eric S. Chai +7 more
wiley +1 more source
A case report on the long‐term use of teduglutide in a pediatric patient with short bowel syndrome
Nutrition in Clinical Practice, EarlyView.Abstract Short bowel syndrome (SBS) is the leading cause of intestinal failure, frequently necessitating long‐term parenteral nutrition (PN). Teduglutide (TED), a glucagon‐like peptide‐2 analog, has demonstrated efficacy in reducing PN dependence in both adults and children. However, long‐term data in pediatric populations remain limited.
Tsuyoshi Sakurai +8 more
wiley +1 more source
Glucagon‐Like Peptide‐1 Receptor Agonists Improve
Alessandro Mantovani +7 more
openalex +1 more source
Effect of Lixisenatide (Short-acting Glucagon-Like Peptide 1 Receptor Agonist) as an Add-on to Insulin in Lowering HbA1C among Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis [PDF]
, 2023 Ashwaq Ali Abusalem, Ahmad Raja Albalawi
openalex +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Background A randomized, double‐blind, placebo‐controlled trial was conducted to evaluate efficacy and safety of glepaglutide in patients who have short bowel syndrome with intestinal failure (SBS‐IF). At the end of the trial, exit interviews were conducted to explore participants' experiences and to assess the impact of the disease and ...
David F. Mercer +5 more
wiley +1 more source
Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking [PDF]
, 2014 Sarah Noerklit Roed +6 more
openalex +1 more source
Endoscopic small bowel therapies for type 2 diabetes
Nutrition in Clinical Practice, EarlyView.Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel +4 more
wiley +1 more source
Examining the Role of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists on the Human Gut Microbiome: A Systematic Review [PDF]
Hezekiah C.T. Au +11 more
openalex +1 more source