Results 1 to 10 of about 74,718 (162)
Potential role of glucagon like peptide 1 in taste receptors [PDF]
Frontiers in EndocrinologyThe perception of taste is a complex physiological process that extends far beyond the simple detection of flavor molecules, serving as a critical interface between nutrient sensing, metabolic regulation, and feeding behavior.
Jose Luis Eduardo Doval-Caballero +11 more
doaj +2 more sources
Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. [PDF]
, 2012 The peptide hormone Urocortin 3 (Ucn 3) is abundantly and exclusively expressed in mouse pancreatic beta cells where it regulates insulin secretion. Here we demonstrate that Ucn 3 first appears at embryonic day (E) 17.5 and, from approximately postnatal ...
Huising, Mark O +5 more
core +14 more sources
Frontiers in Endocrinology, 2021 The mammalian proglucagon gene (Gcg) encodes three glucagon like sequences, glucagon, glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 that are of similar length and share sequence similarity, with these hormones having cell surface receptors,
David M. Irwin, David M. Irwin
doaj +1 more source
Cardiovascular Diabetology, 2023 Background Glucagon is thought to increase heart rate and contractility by stimulating glucagon receptors and increasing 3′,5′-cyclic adenosine monophosphate (cAMP) production in the myocardium.
Ramón Aranda-Domene +4 more
doaj +1 more source
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. [PDF]
PLoS ONE, 2015 This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in this ...
Beatriz Merino +2 more
doaj +1 more source
Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon. [PDF]
PLoS ONE, 2016 GLP-1 and glucagon regulate glucose metabolism through a network of metabolic pathways initiated upon binding to their specific receptors that belong to class B G-protein coupled receptors (GPCRs). The therapeutic potential of glucagon is currently being
Deena A Oren +5 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 Class B G protein-coupled receptors (GPCRs) are important targets in the treatment of metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein complexes have been elucidated, the detailed activation mechanism of the ...
Ying Wang +9 more
doaj +1 more source
Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia
Folia Morphologica, 2020 BACKGROUND: Uraemia leads to a number of metabolic and hormonal disorders including defective carbohydrate metabolism. Endocannabinoids exert their effect on insulin and glucagon secretion via activation of specific receptors named CB1 and CB2.
P. Nowińska +3 more
doaj +1 more source
The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery
Frontiers in Genetics, 2021 Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental ...
Daria Skuratovskaia +7 more
doaj +1 more source
Nature Communications, 2022 Glucagon-like peptide-1 receptor (GLP1R) agonists are used to treat type 2 diabetes (T2D), and polyagonists targeting multiple hormone receptors are investigated as potential therapeutics for T2D.
Hongwei Jiang +12 more
doaj +1 more source