Results 1 to 10 of about 140,006 (312)
Biomedicines, 2022 Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used for the treatment of diabetes. This study examines the effects of dapagliflozin on human islets, focusing on alpha and beta cell composition in relation to function in vivo ...
Daniel Karlsson +9 more
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determine the effects of resistance training on serum levels of GLP-1, DPP-4 and insulin resistance in obese men [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2017 Objective: The aim of this study was to determine the effects of resistance training on serum levels of GLP-1, DPP-4 and insulin resistance in obese men.
Asieh Abbassi-Daloii +3 more
doaj +1 more source
Glucagon Potentiates Insulin Secretion Via β-Cell GCGR at Physiological Concentrations of Glucose
Cells, 2021 Incretin-potentiated glucose-stimulated insulin secretion (GSIS) is critical to maintaining euglycemia, of which GLP-1 receptor (GLP-1R) on β-cells plays an indispensable role.
Yulin Zhang +8 more
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The role of glucagon after bariatric/metabolic surgery: much more than an “anti-insulin” hormone
Frontiers in Endocrinology, 2023 The biological activity of glucagon has recently been proposed to both stimulate hepatic glucose production and also include a paradoxical insulinotropic effect, which could suggest a new role of glucagon in the pathophysiology type 2 diabetes mellitus ...
Gonzalo-Martín Pérez-Arana +12 more
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G protein-coupled receptors and obesity
Frontiers in Endocrinology, 2023 G protein-coupled receptors (GPCRs) have emerged as important drug targets for various chronic diseases, including obesity and diabetes. Obesity is a complex chronic disease that requires long term management predisposing to type 2 diabetes, heart ...
Alessandro Pocai
doaj +1 more source
eLife, 2021 Insulin-induced hypoglycemia is a major treatment barrier in type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating the circulating levels of glucagon.
Angela Kim +23 more
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Metabolites, 2023 (1) Background: Deficiencies of mitochondrial fatty acid oxidation (FAO) define a subgroup of inborn errors of metabolism, with medium-chain acyl-CoA dehydrogenase deficiency (MCAD) and very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) being two ...
Rasmus Stenlid +9 more
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Frontiers in Endocrinology, 2021 AimWe evaluated the efficacy of a novel brain permeable “metformin-like” AMP-activated protein kinase activator, R481, in regulating glucose homeostasis.Materials and MethodsWe used glucose sensing hypothalamic GT1-7 neuronal cells and pancreatic αTC1.9 ...
Ana M. Cruz +8 more
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Excitatory Impact of Dental Occlusion on Dorsal Motor Nucleus of Vagus
Frontiers in Neural Circuits, 2021 Neurons in the trigeminal mesencephalic nucleus (Vme) have axons that branch peripherally to innervate the orofacial region and project centrally to several motor nuclei in brainstem. The dorsal motor nucleus of vagus nerve (DMV) resides in the brainstem
Xin Liu +9 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Glucagon (GCG) plays a stimulatory role in pituitary hormone regulation, although previous studies have not defined the molecular mechanism whereby GCG affects pituitary hormone secretion.
Chaoyi Zhang +3 more
doaj +1 more source