Results 1 to 10 of about 13,383 (111)

Glucose-dependent insulinotropic polypeptide (GIP) [PDF]

Molecular Metabolism
Background: Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin identified and plays an essential role in the maintenance of glucose tolerance in healthy humans.
Timo D. Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L. Birkenfeld, Jonathan E. Campbell, Matthew P. Coghlan, David D'Alessio, Carolyn F. Deacon, Stefano DelPrato, Jonathan D. Douros, Daniel J. Drucker, Natalie S. Figueredo Burgos, Peter R. Flatt, Brian Finan, Ruth E. Gimeno, Fiona M. Gribble, Matthew R. Hayes, Christian Hölscher, Jens J. Holst, Patrick J. Knerr, Filip K. Knop, Christine M. Kusminski, Arkadiusz Liskiewicz, Guillaume Mabilleau, Stephanie A. Mowery, Michael A. Nauck, Aaron Novikoff, Frank Reimann, Anna G. Roberts, Mette M. Rosenkilde, Ricardo J. Samms, Philip E. Scherer, Randy J. Seeley, Kyle W. Sloop, Christian Wolfrum, Denise Wootten, Richard D. DiMarchi, Matthias H. Tschöp   +38 more
doaj   +3 more sources

Roles of glucose‐dependent insulinotropic polypeptide in diet‐induced obesity [PDF]

Journal of Diabetes Investigation, 2022
Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are incretins that play an important role in glucose metabolism, by increasing glucose‐induced insulin secretion from pancreatic β‐cells and help regulate bodyweight ...
Yusuke Seino, Yuji Yamazaki
doaj   +2 more sources

Glucose-dependent insulinotropic polypeptide stimulates post-absorptive lipid secretion in the intestine [PDF]

Frontiers in Physiology
It is increasingly recognized that the intestine can retain a portion of dietary fats for secretion during the post-absorptive state, which has strong implications in metabolic diseases.
Rong Wang, Muhammad Saad Abdullah Khan, Kundanika Mukherjee, Murooj Ghanem, Changting Xiao   +4 more
doaj   +2 more sources

Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women [PDF]

Endocrine Connections
Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in ...
Isidora Salvatierra, Javier Parada, Rodrigo Cataldo, José Eduardo Galgani, Gigliola Alberti, Idoia Labayen, José L Santos   +6 more
doaj   +2 more sources

Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 secretion in humans: Characteristics and regulation [PDF]

Journal of Diabetes Investigation, 2023
Aims/Introduction Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are important incretin hormones. They are released from the gut after meal ingestion and potentiate glucose‐stimulated insulin secretion.
Wathik Alsalim, Ola Lindgren, Bo Ahrén
doaj   +2 more sources

Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice [PDF]

JCI Insight
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are gut-derived peptide hormones that potentiate glucose-dependent insulin secretion.
Rola Hammoud, Kiran Deep Kaur, Jacqueline A. Koehler, Laurie L. Baggio, Chi Kin Wong, Katie E. Advani, Bernardo Yusta, Irina Efimova, Fiona M. Gribble, Frank Reimann, Sigal Fishman, Chen Varol, Daniel J. Drucker   +12 more
doaj   +2 more sources

Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease

Endocrine Reviews
M Michael Wolfe, Michael O Boylan, William W Chin   +2 more
exaly   +2 more sources

Genetically proxied impaired GIPR signaling and risk of 6 cancers

iScience, 2023
Summary: Preclinical and genetic studies suggest that impaired glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling worsens glycemic control. The relationship between GIPR signaling and the risk of cancers influenced by impaired glucose
Miranda Rogers, Dipender Gill, Emma Ahlqvist, Tim Robinson, Daniela Mariosa, Mattias Johansson, Ricardo Cortez Cardoso Penha, Laure Dossus, Marc J. Gunter, Victor Moreno, George Davey Smith, Richard M. Martin, James Yarmolinsky   +12 more
doaj   +1 more source

The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage

Nature Communications, 2022
HNF4A is a nuclear receptor that regulates liver lipid homeostasis. Here the authors show that HNF4A is not required for intestinal lipid metabolism but controls energy expenditure under diet induced obesity through the fat-induced release of glucose ...
Romain Girard, Sarah Tremblay, Christophe Noll, Stéphanie St-Jean, Christine Jones, Yves Gélinas, Faïza Maloum-Rami, Nathalie Perreault, Mathieu Laplante, André C. Carpentier, François Boudreau   +10 more
doaj   +1 more source

Glucose‐dependent insulinotropic polypeptide secretion after oral macronutrient ingestion: The human literature revisited and a systematic study in model experiments in mice

Journal of Diabetes Investigation, 2022
Aims/Introduction The incretin hormone glucose‐dependent insulinotropic polypeptide (GIP) is secreted after meal ingestion. This study explored the relative influence of classes of macronutrients on GIP secretion.
Bo Ahrén
doaj   +1 more source