Results 21 to 30 of about 3,377,180 (268)

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
Isken, Frank, Weickert, Martin O., Pfeiffer, Andreas F. H., Möhlig, Matthias, Abdelrahman, A., Thorens, B., Klaus, Susanne, Nogueiras, R., Tschöp, M. H.   +8 more
core   +1 more source

The Role of Glucose-Dependent Insulinotropic Polypeptide (GIP) in Bone Metabolism. [PDF]

Int J Mol Sci
Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin hormone identified, best known for promoting glucose-stimulated insulin secretion. Increasing evidence has expanded its physiological relevance beyond glucose metabolism, revealing a significant role for GIP in the gut–bone axis.
Lin A, Kitaura H, Ohori F, Marahleh A, Ma J, Fan Z, Narita K, Murakami K, Kanetaka H.   +8 more
europepmc   +3 more sources

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Nature Communications, 2020
Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models.
Elizabeth A. Killion, Michelle Chen, James R. Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M. Véniant, David J. Lloyd   +12 more
doaj   +1 more source

Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists

Endocrinology Research and Practice, 2022
Glucagon-like peptide-1 is the most potent incretin secreted from the intestinal tract. It is synthesized by L-cells in the jejunum and distal ileum of the gastrointestinal system.
Dilek Tüzün
doaj  

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

mAbs, 2020
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases.
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant, Zhulun Wang   +17 more
doaj   +1 more source

Expression of glucose-dependent insulinotropic polypeptide in the zebrafish

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009
In mammals, glucose-dependent insulinotropic polypeptide (GIP) is synthesized predominately in the small intestine and functions in conjunction with insulin to promote nutrient deposition. However, little is known regarding GIP expression and function in early vertebrates like the zebrafish, a model organism representing an early stage in the ...
Michelle C, Musson, Lisa I, Jepeal, Patrick D, Mabray, Irina V, Zhdanova, Wellington V, Cardoso, M Michael, Wolfe   +5 more
openaire   +3 more sources

Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice

Journal of Diabetes Investigation, 2019
Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent ...
Satoko Shimazu‐Kuwahara, Yoshinori Kanemaru, Norio Harada, Eri Ikeguchi, Yohei Ueda, Shunsuke Yamane, Yuki Murata, Akihiro Yasoda, Timothy J Kieffer, Nobuya Inagaki   +9 more
doaj   +1 more source

Glucose-Dependent Insulinotropic Polypeptide Is a Pancreatic Polypeptide Secretagogue in Humans

The Journal of Clinical Endocrinology & Metabolism, 2019
Abstract Background Glucose-dependent insulinotropic polypeptide (GIP) has been suggested to stimulate the secretion of pancreatic polypeptide (PP), an islet hormone thought to regulate gut motility, appetite, and glycemia.
Simon Veedfald, Louise Vedtofte, Kirsa Skov-Jeppesen, Carolyn F Deacon, Bolette Hartmann, Tina Vilsbøll, Filip K Knop, Mikkel B Christensen, Jens J Holst   +8 more
openaire   +3 more sources

Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer’s disease [PDF]

Reviews in the Neurosciences, 2016
AbstractGlucose-dependent insulinotropic polypeptide (GIP) is a member of the incretin hormones and growth factors. Neurons express the GIP receptor, and GIP and its agonists can pass through the blood brain barrier and show remarkable neuroprotective effects by protecting synapse function and numbers, promoting neuronal proliferation, reducing amyloid
Ji, Chenhui, Xue, Guo-Fang, Li, Guanglai, Li, Dongfang, Holscher, Christian   +4 more
openaire   +2 more sources

The equine glucose-dependent insulinotropic polypeptide receptor: A potential therapeutic target for insulin dysregulation [PDF]

, 2017
Metabolic disease is a significant problem that causes a range of species-specific comorbidities. Recently, a better understanding of glucose-dependent insulinotropic polypeptide (GIP) biology has led to the suggestion that inhibiting its action may ...
M. H. Kheder, M. N. Sillence, M. A. de Laat, Bryant, Litticia M., Kheder, M.H., L. M. Bryant, Sillence, M.N., de Laat, M.A.   +7 more
core   +1 more source