Results 11 to 20 of about 13,497 (214)
Glucose-Dependent Insulinotropic Polypeptide [PDF]
Diabetes, 2011 OBJECTIVE To evaluate the glucose dependency of glucose-dependent insulinotropic polypeptide (GIP) effects on insulin and glucagon release in 10 healthy male subjects ([means ± SEM] aged 23 ± 1 years, BMI 23 ± 1 kg/m2, and HbA1c 5.5 ± 0.1%).
Mikkel Christensen +4 more
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Gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide signaling in adipose tissue [PDF]
Journal of Diabetes Investigation, 2019 GIPR signaling in adipose tissue plays an important role in HFD-induced insulin resistance and hepatic steatosis in vivo, with no direct effect on fat accumulation, through IL-6 signaling.
Shunsuke Yamane, Norio Harada
doaj +3 more sources
European Journal of Inflammation, 2022 Glucose-dependent insulinotropic polypeptide (GIP) has pleiotropic actions on pancreatic endocrine function, adipose tissue lipid metabolism, and skeletal calcium metabolism.
Xiaoming He
doaj +1 more source
The Role of Glucose-Dependent Insulinotropic Polypeptide (GIP) in Bone Metabolism. [PDF]
Int J Mol SciGlucose-dependent insulinotropic polypeptide (GIP) was the first incretin hormone identified, best known for promoting glucose-stimulated insulin secretion. Increasing evidence has expanded its physiological relevance beyond glucose metabolism, revealing a significant role for GIP in the gut–bone axis.
Lin A +8 more
europepmc +3 more sources
Regulation of glucose and energy metabolism through actions of glucagon‐like peptide‐1 and glucose‐dependent insulinotropic polypeptide [PDF]
Journal of Diabetes InvestigationYasuo Zenimaru, Norio Harada
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The interplay of glucose-dependent insulinotropic polypeptide in adipose tissue. [PDF]
J EndocrinolAdipose tissue was once known as a reservoir for energy storage but is now considered a crucial organ for hormone and energy flux with important effects on health and disease. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted from the small intestinal K cells, responsible for augmenting insulin release, and has gained ...
Kagdi S, Lyons SA, Beaudry JL.
europepmc +3 more sources
Searching for the physiological role of glucose‐dependent insulinotropic polypeptide [PDF]
Journal of Diabetes Investigation, 2016 AbstractGlucose‐dependent insulinotropic polypeptide (GIP) was established as a gut hormone more than 40 years ago, and there is good experimental support for its role as an incretin hormone although deletion of the GIP receptor or the GIP cells or GIP receptor mutations have only minor effects on glucose metabolism.
Holst, Jens Juul +9 more
openaire +3 more sources
Expression of glucose-dependent insulinotropic polypeptide in the zebrafish
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009 In mammals, glucose-dependent insulinotropic polypeptide (GIP) is synthesized predominately in the small intestine and functions in conjunction with insulin to promote nutrient deposition. However, little is known regarding GIP expression and function in early vertebrates like the zebrafish, a model organism representing an early stage in the ...
Michelle C, Musson +5 more
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Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer’s disease [PDF]
Reviews in the Neurosciences, 2016 AbstractGlucose-dependent insulinotropic polypeptide (GIP) is a member of the incretin hormones and growth factors. Neurons express the GIP receptor, and GIP and its agonists can pass through the blood brain barrier and show remarkable neuroprotective effects by protecting synapse function and numbers, promoting neuronal proliferation, reducing amyloid
Ji, Chenhui +4 more
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Nature Communications, 2020 Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models.
Elizabeth A. Killion +12 more
doaj +1 more source