Results 41 to 50 of about 3,377,180 (268)

Glucose‐Dependent Insulinotropic Polypeptide Modulates Adipocyte Lipolysis and Reesterification [PDF]

Obesity, 2006
AbstractObjective: Glucose‐dependent insulinotropic polypeptide (GIP) is an incretin released from intestinal K‐cells during the postprandial period. Previous studies have suggested that GIP may play an etiologic role in obesity; thus, the GIP receptor may represent a target for anti‐obesity drugs.
Lisa, Getty-Kaushik, Diane H, Song, Michael O, Boylan, Barbara E, Corkey, M Michael, Wolfe   +4 more
openaire   +2 more sources

Exercise-induced anaphylaxis with a cofactor of GIP/GLP-1 receptor agonist: A case report

Journal of Allergy and Clinical Immunology: Global
We report a patient who developed exercise-induced anaphylaxis after starting the dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist tirzepatide, who after discontinuing tirzepatide, experienced resolution of ...
Albert C. Chong, MD, MPH, Amani Elshaer, MBBS, Maximiliano Diaz-Menindez, MD, Jacqueline D. Squire, MD, Alex M. Wonnaparhown, MD, Catherine M. Freeman, MB, BCh   +5 more
doaj   +1 more source

The study of metabolic improvement by nutritional intervention controlling endogenous GIP (Mini Egg study): a randomized, cross-over study

Nutrition Journal, 2019
Background Given the major role of glucose-dependent insulinotropic polypeptide (GIP) in the regulation of adiposity, this study examined the effects induced by a diet based on the Japanese tradition (SMART WASHOKU) on the visceral fat area (VFA) and GIP
Naoki Sakane, Noriko Osaki, Hideto Takase, Junko Suzuki, Chika Suzukamo, Shinsuke Nirengi, Akiko Suganuma, Akira Shimotoyodome   +7 more
doaj   +1 more source

The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury

Cardiovascular Diabetology, 2022
Background The gut incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by enteroendocrine cells following food intake leading to insulin secretion and glucose lowering.
Florian Kahles, Matthias Rau, Martin Reugels, Ann C. Foldenauer, Robert W. Mertens, Maria C. Arrivas, Jörg Schröder, Paul Idel, Julia Moellmann, Emiel P. C. van der Vorst, Nikolaus Marx, Michael Lehrke   +11 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets

Molecules and Cells
: Insulin is essential for maintaining normoglycemia and is predominantly secreted in response to glucose stimulation by β-cells. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, also stimulate ...
Yurong Gao, Hanguk Ryu, Hyejin Lee, Young-Joon Kim, Ji-Hye Lee, Jaemin Lee   +5 more
doaj   +1 more source

Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms

Molecular Metabolism, 2021
Background: Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones that communicate nutrient intake with systemic metabolism. Although GIP was the first incretin hormone to be discovered, the understanding of GIP's biology was ...
Jonathan E. Campbell
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Distinct Identity of GLP-1R, GLP-2R, and GIPR Expressing Cells and Signaling Circuits Within the Gastrointestinal Tract

Frontiers in Cell and Developmental Biology, 2021
Enteroendocrine cells directly integrate signals of nutrient content within the gut lumen with distant hormonal responses and nutrient disposal via the production and secretion of peptides, including glucose-dependent insulinotropic polypeptide (GIP ...
Nadya M. Morrow, Nadya M. Morrow, Antonio A. Hanson, Antonio A. Hanson, Erin E. Mulvihill, Erin E. Mulvihill, Erin E. Mulvihill, Erin E. Mulvihill   +7 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source