Results 1 to 10 of about 8,656 (193)
Indian Journal of Endocrinology and Metabolism, 2012 Nutrient excess results in systemic inflammation in diabetes contributing to insulin resistance, dyslipidaemia and increased cardiovascular risk. GLP-1 agonists and DPP-4 inhibitors, which are now well accepted therapies for diabetes may play a unique ...
Amitabh Hatwal
doaj +3 more sources
Evaluation of the risk of fracture in type 2 diabetes mellitus patients with incretins: an updated meta-analysis [PDF]
Endokrynologia Polska, 2021 INTRODUCTION: The effect of incretins including dipeptidyl peptidase 4 inhibitors (DPP4-Is) and glucagon-like peptide1 receptor agonists (GLP1-ras) in the treatment of type 2 diabetes increasing the risk of fracture remains controversial.
Qing-xin Kong +5 more
doaj +2 more sources
Pharmaceutics, 2023 Atherosclerosis is the leading cause of death worldwide, especially in patients with type 2 diabetes mellitus (T2D). GLP-1 receptor agonists and DPP-4 inhibitors were demonstrated to play a markedly protective role for the cardiovascular system beyond ...
Gian Paolo Ussia +2 more
exaly +3 more sources
Physiological Reports, 2019 Bariatric surgery is now the most widely used intervention for the treatment of human obesity. A large body of literature has demonstrated its efficacy in sustained weight loss and improvement in its associated comorbidities.
Matthew J Brady +2 more
exaly +2 more sources
Hyperglycaemia induced osteoporosis: Is there a hope with dipeptidyl peptidase-4 inhibitors?
Health Sciences Review, 2023 Diabetes mellitus and osteoporosis are chronic illnesses associated with adverse health outcomes. Studies have reported common linkages between energy and bone metabolism.
Faraha Ahmed +8 more
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Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes
Medicina, 2022 The current management of Type 2 Diabetes Mellitus (T2DM) includes incretin-based treatments able to enhance insulin secretion and peripheral insulin sensitivity as well as improve body mass, inflammation, plasma lipids, blood pressure, and ...
Angelo Maria Patti +10 more
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The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion
Metabolites, 2022 The enteroendocrine system of the gut regulates energy homeostasis through the release of hormones. Of the gut-derived hormones, GLP-1 is particularly interesting, as analogs of the hormone have proven to be highly effective for the treatment of type 2 ...
Anna Pii Hjørne +2 more
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Scientific Reports, 2022 It has not been elucidated whether incretins affect insulin clearance in type 2 diabetes (T2D). We aimed exploring possible associations between insulin clearance and endogenously secreted or exogenously administered incretins in T2D patients. Twenty T2D
Andrea Tura +4 more
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Metabolites, 2021 Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber +5 more
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Potential Therapeutic Strategies in the Treatment of Metabolic-Associated Fatty Liver Disease
Medicina, 2023 Metabolic-associated Fatty Liver Disease is one of the outstanding challenges in gastroenterology. The increasing incidence of the disease is undoubtedly connected with the ongoing obesity pandemic.
Aleksandra Bołdys +4 more
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