Results 31 to 40 of about 8,133 (247)

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. [PDF]

, 2013
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Hofmann, S., Smiley, D.L., Tschöp, M.H., Heppner, K.M., DiMarchi, R.D., Riboulet, W., Habegger, K.M., Lau, M., Ma, T., Zhang, L., Drucker, D.J., Kirchner, H., Hembree, J., Sebokova, E., Finan, B., Uhles, S., Raver, C., Gidda, J., Gelfanov, V., Ottaway, N., Holland, J., Pfluger, P.T., Lockie, S.H., Hainaut, E., Müller, T.D., Hauptman, J.B., Conde-Knape, K., Vignati, L., Yang, B., Bruemmer, D., Brecheisen, M., Perez-Tilve, D., Konkar, A.   +32 more
core   +3 more sources

Renal effects of glucagon-like peptide receptor agonists in patients with type 1 diabetes mellitus [PDF]

Терапевтический архив, 2018
The purpose of our study is to assess the effects of glucagon-like peptide-1 receptor agonists (GLP-1R agonists) on early markers of kidney damage in patients with type 1 diabetes mellitus (DM). Materials and methods.
O K Vikulova, Z T Zuraeva, O V Michaleva, L V Nikankina, M Sh Shamkhalova, M V Shestakova, I I Dedov   +6 more
doaj   +1 more source

Features of the functional state of the enteropancreatic hormonal system in pregnant women with gestational diabetes mellitus

Сахарный диабет, 2023
Features of the functional state of the enteropancreatic hormonal system in pregnant women with gestational diabetes mellitus© Fatima O. Ushanova1*, Tatiana Y. Demidova1, Tatiana N. Korotkova21Pirogov Russian National Research Medical University, Moscow,
F. O. Ushanova, T. Y. Demidova, T. N. Korotkova   +2 more
doaj   +1 more source

The entero-insular axis in type 2 diabetes - incretins as therapeutic agents [PDF]

, 2001
The search for intestinal factors regulating the endocrine secretion of the pancreas started soon after the discovery of secretin, i.e. nearly 100 years ago.
Creutzfeldt, W., W. Creutzfeldt
core   +1 more source

Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity. [PDF]

, 2013
An important role in the regulation of glucose homeostasis is played by incretins, which are gut-derived hormones released in response to nutrient ingestion.
Opinto G, MARCHETTI, PIERO, Natalicchio A   +2 more
core   +1 more source

The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease [PDF]

, 2023
In the last few decades, glucagon-like peptide-1 receptor (GLP-1R) agonists have changed current guidelines and improved outcomes for individuals with type 2 diabetes.
Andreasen, Christine R., Andreas Andersen, Christine R. Andreasen, Vilsbøll, Tina, Tina Vilsbøll, Andersen, Andreas   +5 more
core   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

The role of incretins on insulin function and glucose homeostasis [PDF]

, 2021
The incretin effect - the amplification of insulin secretion after oral versus intravenous administration of glucose as a mean to improve glucose tolerance - was suspected even before insulin was discovered, and today we know that the effect is due to ...
Holst, Jens Juul, Rosenkilde, Mette Marie, Gasbjerg, Lærke Smidt   +2 more
core   +1 more source

Glucagon-like peptide-1 analogues: An overview

Indian Journal of Endocrinology and Metabolism, 2013
Abnormalities of the incretin axis have been implicated in the pathogenesis of type 2 diabetes mellitus. Glucagon-like peptide-1 (GLP-1) and gastroinhibitory intestinal peptide constitutes >90% of all the incretin function.
Vishal Gupta
doaj   +1 more source

Intestinal neuroendocrine cells exposed to skim milk powder with a high content of Maillard reactants show an attenuated secretion of incretins

Journal of Dairy Science
: Incretins such as glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play crucial roles in postprandial glucose management.
Mona Landin-Olsson, Birgitte Ekholm, Charlotte Erlanson-Albertsson, Cecilia Holm   +3 more
doaj   +1 more source