Results 31 to 40 of about 8,656 (193)

Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4 [PDF]

, 2017
Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is ...
Takayuki K. Nemoto, Yuko Ohara-Nemoto, Manami Nakasato, Ohara-Nemoto, Yuko, Shigenobu Kimura, Yaegashi, Takashi, Baba, Tomomi T., Ono, Toshio, Takeshi Kobayakawa, Nakasato, Manami, Toshio Ono, Nemoto, Takayuki K., Yu Shimoyama, Kobayakawa, Takeshi, Tomomi T. Baba, Kimura, Shigenobu, Shimoyama, Yu, Takashi Yaegashi   +17 more
core   +2 more sources

The effects of macronutrients composition on hormones and substrates during a meal tolerance test in drug-naive and sitagliptin-treated individuals with type 2 diabetes: a randomized crossover study

Archives of Endocrinology and Metabolism, 2022
Objectives: To evaluate the effect of sitagliptin treatment in early type 2 diabetes mellitus (T2DM) and the impact of different macronutrient compositions on hormones and substrates during meal tolerance tests (MTT).
Cristina da Silva Schreiber, Alex Rafacho, Renata Silverio, Roberto Betti, Antonio Carlos Lerário, Ana Maria Pita Lotenberg, Klara Rahmann, Carolina Piras de Oliveira, Bernardo Léo Wajchenberg, Protásio Lemos da Luz   +9 more
doaj   +1 more source

Update on incretin hormones [PDF]

Annals of the New York Academy of Sciences, 2011
The incretin hormones glucagon‐like‐peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) are released from the intestine following oral ingestion of nutrients. Incretins promote insulin secretion, while GLP‐1 also inhibits glucagon release and gastric emptying, minimizing postprandial glucose excursions.
Phillips, Liza K., Prins, Johannes B.
openaire   +5 more sources

Prevalence of hypoglycaemia in a random population after Roux-en-Y gastric bypass after a meal test

Endocrine Connections, 2019
Objective: Roux-en-Y gastric bypass (RYGB) is an effective way to induce sustainable weight loss and can be complicated by postprandial hyperinsulinaemic hypoglycaemia (PHH).
Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel, André P van Beek   +8 more
doaj   +1 more source

Choosing a Gliptin

Indian Journal of Endocrinology and Metabolism, 2011
The treatment of type 2 diabetes mellitus (T2DM) has included the use of metformin and sulfonylurea (SU) as first-line anti-diabetic therapies world over since years.
Vishal Gupta, Sanjay Kalra
doaj   +1 more source

Intestinal neuroendocrine cells exposed to skim milk powder with a high content of Maillard reactants show an attenuated secretion of incretins

Journal of Dairy Science
: Incretins such as glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play crucial roles in postprandial glucose management.
Mona Landin-Olsson, Birgitte Ekholm, Charlotte Erlanson-Albertsson, Cecilia Holm   +3 more
doaj   +1 more source

GLP-1 and GIP in Type 1 Diabetes Therapy: A Time for Reappraisal?

Diabetology
Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are essential regulators of glucose homeostasis, energy balance, and metabolic communication between organs.
Grazia Piras, Sara Brasili, Davide Demontis, Leonardo Della Sala, Francesco Cocchiara, Davide Carlo Maggi, Anna Arecco   +6 more
doaj   +1 more source

DIPEPTIDYL DIPEPTIDASE-4: VIEW OF THE CLINICAL PHARMACOLOGIST

Медицинский совет, 2016
A deeper understanding of the pathogenesis of the 2nd type diabetes mellitus, including postprandial control of glucose homeostasis has led to new treatment strategies aimed at overcoming the dysfunction in the pancreatic islets and, in particular ...
N. B. LAZAREVA
doaj   +1 more source

GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion [PDF]

Molecular and Cellular Endocrinology, 2007
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins secreted in response to oral glucose ingestion by intestinal L and K cells, respectively. The molecular mechanisms responsible for intestinal cell glucose sensing are unknown but could be related to those described for beta-cells, brain and hepatoportal
Cani, P.D., Holst, J.J., Drucker, D.J., Delzenne, N.M., Thorens, B., Burcelin, R., Knauf, C.   +6 more
openaire   +4 more sources

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

eLife
G protein-coupled receptors (GPCRs) are integral membrane proteins which closely interact with their plasma membrane lipid microenvironment. Cholesterol is a lipid enriched at the plasma membrane with pivotal roles in the control of membrane fluidity and
Affiong Ika Oqua, Kin Chao, Liliane El Eid, Lisa Casteller, Billy P Baxter, Alba Miguéns-Gómez, Sebastian Barg, Ben Jones, Jorge Bernardino de la Serna, Sarah L Rouse, Alejandra Tomas   +10 more
doaj   +1 more source