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Obesity without diabetes: the role of hormonal regulation
Терапевтический архив, 2020 Aim.Obese patients without diabetes present an interesting phenotype to explore protective mechanisms against type 2 diabetes (T2D) development. In our study we looked for specific hormonal features of obese patients without T2D. Materials and methods.
E. A. Shestakova +5 more
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Frontiers in Pharmacology, 2022 GPR40 is a class A G-protein coupled receptor (GPCR) mainly expressed in pancreas, intestine, and brain. Its endogenous ligand is long-chain fatty acids, which activate GPR40 after meal ingestion to induce secretion of incretins in the gut, including GLP-
Hong-Ping Guan, Yusheng Xiong
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Медицинский совет, 2020 The article discusses the potential opportunities for impact of antidiabetic drugs from the group of glucagon-like peptide-1 (GLP- 1) receptor agonists on the risks of development and progression of cardiovascular complications in patients with type 2 ...
Yu. Sh. Khalimov, V. G. Kuzmich
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orlistat improves release of gut hormones increasing satiety in obese women
Ожирение и метаболизм, 2014 Orlistat, which reduces fat absorption by inhibiting intestinal lipase is a registered drug for obesity pharmacotherapy. Meta-analyzes indicate various positive metabolic effects of orlistat, including improvements in glucose and lipid metabolism ...
Teona Albertovna Shvangiradze
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Incretin secretion and glucose metabolism in morbidly obese patients in the early and late periods after biliopancreatic diversion [PDF]
Терапевтический архив, 2016 Aim. To estimate the parameters of glucose metabolism and to assess the secretion of incretins in patients after biliopancreatic diversion (BPD) for morbid obesity (MO) in the early and late postoperative periods. Subjects and methods.
I I Dedov +7 more
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Small intestinal physiology relevant to bariatric and metabolic endoscopic therapies: Incretins, bile acid signaling, and gut microbiome [PDF]
, 2020 Incretins, bile acids and the gut microbiome are involved in the pathophysiology of obesity and type 2 diabetes. The incretins glucagon-like peptide-1 and glucose-dependent-insulinetrophic polypeptide, both influence beta-cell function, insulin and ...
Maurits de Brauw +13 more
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Glucagon-Like Peptide-1 and Hypothalamic Regulation of Satiation: Cognitive and Neural Insights from Human and Animal Studies [PDF]
Diabetes & Metabolism JournalGlucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as blockbuster drugs for treating metabolic diseases. Glucagon-like peptide-1 (GLP-1) plays a pivotal role in glucose homeostasis by enhancing insulin secretion, suppressing glucagon ...
Joon Seok Park +2 more
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Renal experiences of bariatric surgery in patients with type 2 diabetes mellitus [PDF]
Терапевтический архив, 2018 The review addresses the questions of the literature devoted to the problem of the influence of bariatric surgery on the course of diabetic nephropathy in patients with diabetes mellitus type 2 after achieving a surgically induced remission.
I I Larina +3 more
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Incretins today: multiple effects and therapeutic potential [PDF]
, 2019 Glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) are the incretin hormones initially discovered in the 1960s. GIP and GLP-1 have gained great scientific interest due to their properties in increasing insulin secretion ...
Varvara V. Veretyuk +2 more
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Biomedicines, 2022 Diabetes mellitus is the leading cause of chronic kidney disease, and about 30–40% of patients with diabetes will develop kidney disease. Incretin hormones have received attention during the past three decades not only as a pharmacotherapy for the ...
Tomislav Bulum
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