Journal of Physiology, 2022 Insulin infusion increases skeletal muscle microvascular blood flow (MBF) in healthy people but is impaired during insulin resistance. However, we have shown that eliciting insulin secretion via oral glucose loading in healthy people impairs muscle MBF ...
K. Roberts-Thomson +6 more
semanticscholar +1 more source
The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery
Frontiers in Genetics, 2021 Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental ...
D. Skuratovskaia +7 more
semanticscholar +1 more source
Incretins: Their physiology and application in the treatment of diabetes mellitus
Diabetes/Metabolism Research and Reviews, 2014 Hasan Altunbas, Salih Sanlioglu
exaly +2 more sources
Scientific Reports, 2022 It has not been elucidated whether incretins affect insulin clearance in type 2 diabetes (T2D). We aimed exploring possible associations between insulin clearance and endogenously secreted or exogenously administered incretins in T2D patients. Twenty T2D
Andrea Tura +4 more
doaj +1 more source
Asian Subpopulations May Exhibit Greater Cardiovascular Benefit from Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A Meta-Analysis of Cardiovascular Outcome Trials [PDF]
Diabetes & Metabolism Journal, 2019 BackgroundBased on reported results of three large cardiovascular outcome trials (CVOTs) of glucagon-like peptide 1 receptor agonists (GLP-1 RAs), we aimed to investigate the overall effect of GLP-1 RAs on major adverse cardiovascular events (MACEs) and ...
Yu Mi Kang +8 more
doaj +1 more source
Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects [PDF]
, 2015 Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease.
ANGELICO, Francesco +10 more
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Genetic variants affecting incretin sensitivity and incretin secretion [PDF]
Diabetologia, 2010 Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these type 2 diabetes risk variants confer impaired pancreatic beta cell function. Though the molecular mechanisms by which common genetic variation within these loci affects beta cell function are not completely understood, risk variants may
K, Müssig +4 more
openaire +2 more sources
Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists [PDF]
, 2017 Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications.
Chantal Chenu +4 more
core +5 more sources
Metformin in prediabetes: key mechanisms for the prevention of diabetes and cardiometabolic risks
Медицинский совет, 2022 Today, prediabetes is regarded by the world medical community as early diabetes mellitus. The accumulated research evidence shows that prediabetes is characterized by a spectrum of complications that are similar to those of diabetes mellitus, which means
A. Yu. Babenko
doaj +1 more source
Experimental and clinical pharmacology - Incretin mimetics and enhancers: mechanisms of action [PDF]
, 2008 The incretins are peptide hormones secreted from the gut in response to food. They increase the secretion of insulin. The incretin response is reduced in patients with type 2 diabetes, so drugs acting on incretins may improve glycaemic control. Incretins
Prins, Johannes B.
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