Results 41 to 50 of about 8,133 (247)

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Incretins and SGLT2 inhibitors [PDF]

, 2014
Diabetes is one of the earliest diseases documented that mankind still hasn‘t found a cure against, with historical documents dating as far back as c. 1500 BCE. Modern medicine has certainly come a long way, as new treatments emerge regularly.
Agnarsson, Kristinn
core  

Oral and intravenous glucose administration elicit opposing microvascular blood flow responses in skeletal muscle of healthy people: role of incretins [PDF]

, 2022
: Insulin infusion increases skeletal muscle microvascular blood flow (MBF) in healthy people but is impaired during insulin resistance. However, we have shown that eliciting insulin secretion via oral glucose loading in healthy people impairs muscle MBF,
Roberts-Thomson, KM, Andrew C. Betik, Michelle A. Keske, Wadley, GD, Marwick, Thomas H., Lewan Parker, Thomas H. Marwick, Wadley, Glenn D., Gatta, PAD, Keske, MA, Betik, Andrew C., Roberts‐Thomson, Katherine M., Parker, L, Katherine M. Roberts‐Thomson, Keske, Michelle A., Glenn D. Wadley, Gatta, Paul A. Della, Marwick, TH, Betik, AC, Parker, Lewan, Paul A. Della Gatta   +20 more
core   +1 more source

GLP-1 and GIP in Type 1 Diabetes Therapy: A Time for Reappraisal?

Diabetology
Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are essential regulators of glucose homeostasis, energy balance, and metabolic communication between organs.
Grazia Piras, Sara Brasili, Davide Demontis, Leonardo Della Sala, Francesco Cocchiara, Davide Carlo Maggi, Anna Arecco   +6 more
doaj   +1 more source

Problems of hypoglycemic therapy in diabetic patients with acute coronary syndrome

Медицинский совет, 2016
Patients with diabetes mellitus (DM) are classified as "vulnerable patients" suffering from acute coronary syndrome (ACS) 2-3 times more often and have a pessimistic prognosis compared with normoglycemic patients.
L. A. Ruyatkina, D. S. Ruyatkin, A. K. Ovsyannikova   +2 more
doaj   +1 more source

Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches

Biology, 2020
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from the gut upon nutrient stimulation and regulate postprandial metabolism.
Geke Aline Boer, Jens Juul Holst
doaj   +1 more source

The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion

Metabolites, 2022
The enteroendocrine system of the gut regulates energy homeostasis through the release of hormones. Of the gut-derived hormones, GLP-1 is particularly interesting, as analogs of the hormone have proven to be highly effective for the treatment of type 2 ...
Anna Pii Hjørne, Ida Marie Modvig, Jens Juul Holst   +2 more
doaj   +1 more source

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Chronic Diseases and Translational Medicine, EarlyView.
Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig, Jason Ta, Sophie Jones, Emily Scott, Khalid Sofi, Frances Osler, Marije Jansen, Puneet Chhabra   +7 more
wiley   +1 more source

Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4 [PDF]

, 2017
Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is ...
Takayuki K. Nemoto, Yuko Ohara-Nemoto, Manami Nakasato, Ohara-Nemoto, Yuko, Shigenobu Kimura, Yaegashi, Takashi, Baba, Tomomi T., Ono, Toshio, Takeshi Kobayakawa, Nakasato, Manami, Toshio Ono, Nemoto, Takayuki K., Yu Shimoyama, Kobayakawa, Takeshi, Tomomi T. Baba, Kimura, Shigenobu, Shimoyama, Yu, Takashi Yaegashi   +17 more
core   +3 more sources