Results 51 to 60 of about 8,656 (193)

Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity.

, 2013
An important role in the regulation of glucose homeostasis is played by incretins, which are gut-derived hormones released in response to nutrient ingestion.
Opinto G, MARCHETTI, PIERO, Natalicchio A   +2 more
core   +1 more source

Incretins and their influence on the course of type 2 diabetes in patients with morbid obesity after bariatric oper [PDF]

, 2012
Most researchers support the important role of incretins, particularly glucagon-like peptide-1 in improving metabolic control in patients with type 2 diabetes after bariatric operations, mostly involving shunting.

core   +1 more source

Type 2 diabetes mellitus: time to change the concept

Сахарный диабет, 2013
Diabetes mellitus is a heterogeneous group of diseases that, although unified by a number of characteristics, require a differential thera- peutic approach.
Shmuel Levit, Yury Ivanovich Filippov, A S Gorelyshev   +2 more
doaj   +1 more source

The Therapeutic Potential of Glucagon-like Peptide 1 Receptor Agonists in Traumatic Brain Injury

Pharmaceuticals
Traumatic brain injury (TBI), which is a global public health concern, can take various forms, from mild concussions to blast injuries, and each damage type has a particular mechanism of progression.
Anja Harej Hrkać, Kristina Pilipović, Andrej Belančić, Lea Juretić, Dinko Vitezić, Jasenka Mršić-Pelčić   +5 more
doaj   +1 more source

Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus

Сахарный диабет, 2013
For the past several years, a number of studies addressed glucagon and its role in glycemic homeostasis and the development of diabetes mellitus. Current review discusses basic developmental stages of pancreatic islets with special regard for the ...
Nina Alexandrovna Petunina, Lyubov' Valentinovna Trukhina, Elena Igorevna Sinicyna, Marina Vladimirovna Shestakova   +3 more
doaj   +1 more source

Obesity without diabetes: the role of hormonal regulation

Терапевтический архив, 2020
Aim.Obese patients without diabetes present an interesting phenotype to explore protective mechanisms against type 2 diabetes (T2D) development. In our study we looked for specific hormonal features of obese patients without T2D. Materials and methods.
E. A. Shestakova, I. A. Sklyanik, A. S. Panevina, L. V. Nikankina, M. V. Shestakova, I. I. Dedov   +5 more
doaj   +1 more source

The role of incretins on insulin function and glucose homeostasis

, 2021
The incretin effect - the amplification of insulin secretion after oral versus intravenous administration of glucose as a mean to improve glucose tolerance - was suspected even before insulin was discovered, and today we know that the effect is due to ...
Holst, Jens Juul, Rosenkilde, Mette Marie, Gasbjerg, Lærke Smidt   +2 more
core   +1 more source

The use of incretins and fractures - a meta-analysis on population-based real life data [PDF]

, 2017
The aim of the present study was to estimate the effect of incretins on fracture risk in the real world situation by meta-analysis of the available population-based cohort data.Pubmed and Embase were searched for original articles investigating use of ...
Henry, R.M.A., Driessen, J.H.M., Harvey, N.C., van den Bergh, J., de Vries, F., van Onzenoort, H., Neef, C., Vestergaard, P.   +7 more
core   +2 more sources

Organoprotective effects of glucagon-like peptide-1 receptor agonists with regard to findings of evidencebased cardiovascular safety studies

Медицинский совет, 2020
The article discusses the potential opportunities for impact of antidiabetic drugs from the group of glucagon-like peptide-1 (GLP- 1) receptor agonists on the risks of development and progression of cardiovascular complications in patients with type 2 ...
Yu. Sh. Khalimov, V. G. Kuzmich
doaj   +1 more source

The biology of incretin hormones [PDF]

Cell Metabolism, 2006
Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate glucose-dependent insulin secretion. Both GIP and GLP-1 also promote beta cell proliferation and inhibit apoptosis, leading to expansion of beta cell mass.
openaire   +2 more sources