Results 61 to 70 of about 8,656 (193)

The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease

, 2023
In the last few decades, glucagon-like peptide-1 receptor (GLP-1R) agonists have changed current guidelines and improved outcomes for individuals with type 2 diabetes.
Andreasen, Christine R., Andreas Andersen, Christine R. Andreasen, Vilsbøll, Tina, Tina Vilsbøll, Andersen, Andreas   +5 more
core   +1 more source

Incretins and SGLT2 inhibitors

, 2014
Diabetes is one of the earliest diseases documented that mankind still hasn‘t found a cure against, with historical documents dating as far back as c. 1500 BCE. Modern medicine has certainly come a long way, as new treatments emerge regularly.
Agnarsson, Kristinn
core  

The Regulation of Metabolic Homeostasis by Incretins and the Metabolic Hormones Produced by Pancreatic Islets [PDF]

In healthy humans, the complex biochemical interplay between organs maintains metabolic homeostasis and pathological alterations in this process result in impaired metabolic homeostasis, causing metabolic diseases such as diabetes and obesity, which are ...
Steve Bain, Venkat Kanamarlapudi
core   +1 more source

Secretion of incretin hormones in people having risk factors for type 2 diabetes mellitus

Терапевтический архив, 2014
AIM. To study the secretion of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 2 (GLP-2) in response to a carbohydrate load in people with risk factors for type 2 diabetes mellitus (DM2) in ...
E A Shestakova, A V Il'in, M V Shestakova, I I Dedov   +3 more
doaj  

Glucagon-Like Peptide-1 and Hypothalamic Regulation of Satiation: Cognitive and Neural Insights from Human and Animal Studies [PDF]

Diabetes & Metabolism Journal
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as blockbuster drugs for treating metabolic diseases. Glucagon-like peptide-1 (GLP-1) plays a pivotal role in glucose homeostasis by enhancing insulin secretion, suppressing glucagon ...
Joon Seok Park, Kyu Sik Kim, Hyung Jin Choi   +2 more
doaj   +1 more source

Oral and intravenous glucose administration elicit opposing microvascular blood flow responses in skeletal muscle of healthy people: role of incretins

, 2022
: Insulin infusion increases skeletal muscle microvascular blood flow (MBF) in healthy people but is impaired during insulin resistance. However, we have shown that eliciting insulin secretion via oral glucose loading in healthy people impairs muscle MBF,
Roberts-Thomson, KM, Andrew C. Betik, Michelle A. Keske, Wadley, GD, Marwick, Thomas H., Lewan Parker, Thomas H. Marwick, Wadley, Glenn D., Gatta, PAD, Keske, MA, Betik, Andrew C., Roberts‐Thomson, Katherine M., Parker, L, Katherine M. Roberts‐Thomson, Keske, Michelle A., Glenn D. Wadley, Gatta, Paul A. Della, Marwick, TH, Betik, AC, Parker, Lewan, Paul A. Della Gatta   +20 more
core   +1 more source

The integrated incretin effect is reduced by both glucose intolerance and obesity in Japanese subjects

Frontiers in Endocrinology
IntroductionIncretin-based drugs are extensively utilized in the treatment of type 2 diabetes (T2D), with remarkable clinical efficacy. These drugs were developed based on findings that the incretin effect is reduced in T2D.
Akihiro Hamasaki, Akihiro Hamasaki, Norio Harada, Atsushi Muraoka, Shunsuke Yamane, Erina Joo, Kazuyo Suzuki, Nobuya Inagaki   +7 more
doaj   +1 more source

The Origin and Understanding of the Incretin Concept [PDF]

Frontiers in Endocrinology, 2018
Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy.
openaire   +4 more sources

Physiology of incretins in health and disease

, 2011
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are gut peptides which are secreted by endocrine cells in the intestinal mucosa.
Deacon, Carolyn F., Ahren, Bo
core   +1 more source

The effect of sweeteners on carbohydrate metabolism, metabolic parameters and intestinal microbiota

Ожирение и метаболизм
The prevalence of obesity and type 2 diabetes continues to grow, which determines the need to develop new methods of prevention in order to reduce the population risks of developing these diseases.
N. V. Silina, N. V. Mazurina, E. V. Ershova, K. A. Komshilova   +3 more
doaj   +1 more source