Results 81 to 90 of about 8,656 (193)

Deciphering obesity: a conceptual overview and synthesis

Frontiers in Endocrinology
Obesity represents a multifactorial disorder rooted in genetic, developmental, and environmental influences. Its persistence and heterogeneity warrant deeper understanding of pathology beyond genetic determinism. This Perspective synthesizes a conceptual
Rashmi Prakash, Anshu Arora, Arif Khan, Arif Khan   +3 more
doaj   +1 more source

Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

, 2018
Background The main causes of COPD are tobacco smoking (COPD-TS) and biomass smoke exposure (COPD-BS). COPD-TS is known to induce changes in adipokines, incretins, and peptide hormones, frequent biomarkers of inflammation; however, it is unknown if ...
Yadira Velasco-Torres, Joaquín Zúñiga-Ramos, Tonatiuh Barrientos-Gutiérrez, Martha Montaño, Carlos Ramos, Rogelio Pérez-Padilla, Mariana Camacho-Priego, Oliver Pérez-Bautista, Ivette Buendía-Roldan   +8 more
core   +1 more source

Peptide LKLKLL is a more effective component of Akkermansia muciniphila which regulate glucolipid metabolism through GLP-1/GIP dual modulation

Gut Microbes
The ability of Akkermansia muciniphila (AKK) to ameliorate metabolic dysfunction has attracted increasing attention as a potential strategy for obesity and diabetes management.
Yuan Li, Dasen Ye, Caiyan Fu, Xingli Huang, Qingqing Ma, Fan Zhang, Gengyue Chen, Pingping Song, Changqing Kong, Jiaxing Wu, Hao Wu, Jianjun Qiao, Juhong Yang   +12 more
doaj   +1 more source

Incretin hormones and obesity

The Journal of Physiology
Abstract The incretin hormones glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) play critical roles in co‐ordinating postprandial metabolism, including modulation of insulin secretion and food intake.
Constanza Alcaino, Frank Reimann, Fiona M. Gribble   +2 more
openaire   +3 more sources

Glucagon-like peptide-1 receptor agonists and the endothelium: molecular and clinical insights into cardiovascular protection

Frontiers in Medicine
Endothelial dysfunction represents the critical pathophysiological mediator linking the modern epidemics of obesity, type 2 diabetes mellitus, and cardiovascular disease.
Allegra Battistoni, Linda Piras, Nicola Tartaglia, Francesco Maria Carrano, Claudia De Vitis, Emanuele Barbato   +5 more
doaj   +1 more source

Comparative effects of SGLT2 inhibitors and incretin-based therapies on dementia risk in type 2 diabetes: a systematic review and meta-analysis

Frontiers in Endocrinology
BackgroundAntidiabetic drugs lower blood glucose levels and may also have neuroprotective and vascular protection effects. In particular, sodium–glucose cotransporter 2 inhibitors (SGLT2is) and incretin mimetics have demonstrated dementia-reducing ...
Kirim Song, Kirim Song, Jiwon Choi, Dayeon Jeong, Dayeon Jeong, Dongyun Shin, Young-Mi Ah, Ki Young Lee, Ki Young Lee, Kyung Hee Choi, Kyung Hee Choi   +10 more
doaj   +1 more source

Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy

Cell Reports Medicine
Summary: Glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) agonists have recently been shown to play a significant role in the treatment of diabetes and obesity.
Ruben Rodriguez, Anne Hergarden, Shyam Krishnan, Marikris Morales, Davina Lam, Ted Tracy, Teresa Tang, Avalon Patton, Craig Lee, Asmita Pant, Daniel A. Erlanson, Johan Enquist, Derek Bone, Ray Fucini, Damian Bialonczyk, Stig K. Hansen, Jian Luo, Manu V. Chakravarthy   +17 more
doaj   +1 more source

Physiology and pathophysiology of incretins in the kidney

, 2014
Purpose of reviewIncretin-based therapy with glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors is considered a promising therapeutic option for type 2 diabetes mellitus.
Reichetzeder, Christoph, Hocher, Berthold (Prof.), von Websky, Karoline   +2 more
core   +1 more source

Incretin Concepts [PDF]

Diabetes Care, 2010
openaire   +2 more sources

Compounded incretins in clinical practice: An opinion of the endocrine and metabolism practice and research network of the American College of Clinical Pharmacy.

AIMS: This article aims to summarize the role of compounded incretin mimetics in clinical practice and in the context of drug shortages. METHODS: The Endocrine and Metabolism Practice and Research Network, a focused group of the American College of ...
Courtney, Lindsay A, Isaacs, Diana, Reece, Sara Mandy, Whitley, Heather P, Pitlick, Jamie M, Clements, Jennifer N   +5 more
core   +1 more source