Results 81 to 90 of about 8,158 (292)

Different antihyperglycaemic drug effects on glycaemic variability in Type 2 diabetic patients

Сахарный диабет, 2014
Optimizing treatments for type 2 diabetes mellitus (T2DM) remains an urgent issue. In addition to T2DM treatment strategies, such as glycaemic goals (glucose and glycated haemoglobin ?
Alina Babenko, Elena Ivanovna Krasilnikova, Nikolay Pavlovich Likhonosov, Anna Pavlovna Likhonosova, Elena Nikolaevna Grineva   +4 more
doaj   +1 more source

Evaluating the Evolving Real‐World Adverse Events of GLP‐1RAs Using FDA Adverse Event Reporting System (FAERS)

Obesity, EarlyView.
Web portal for interrogating Adverse Events of GLP‐1 RA in diabetes vs weight control/obesity. ABSTRACT Objective This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) using the US FDA Adverse Event Reporting System (FAERS).
David Stone, Mary Playdon, Stephen D. Hursting, Aik Choon Tan   +3 more
wiley   +1 more source

Incretins and SGLT2 inhibitors

, 2014
Diabetes is one of the earliest diseases documented that mankind still hasn‘t found a cure against, with historical documents dating as far back as c. 1500 BCE. Modern medicine has certainly come a long way, as new treatments emerge regularly.
Agnarsson, Kristinn
core  

The Regulation of Metabolic Homeostasis by Incretins and the Metabolic Hormones Produced by Pancreatic Islets [PDF]

In healthy humans, the complex biochemical interplay between organs maintains metabolic homeostasis and pathological alterations in this process result in impaired metabolic homeostasis, causing metabolic diseases such as diabetes and obesity, which are ...
Steve Bain, Venkat Kanamarlapudi
core   +1 more source

Oral and intravenous glucose administration elicit opposing microvascular blood flow responses in skeletal muscle of healthy people: role of incretins

, 2022
: Insulin infusion increases skeletal muscle microvascular blood flow (MBF) in healthy people but is impaired during insulin resistance. However, we have shown that eliciting insulin secretion via oral glucose loading in healthy people impairs muscle MBF,
Roberts-Thomson, KM, Andrew C. Betik, Michelle A. Keske, Wadley, GD, Marwick, Thomas H., Lewan Parker, Thomas H. Marwick, Wadley, Glenn D., Gatta, PAD, Keske, MA, Betik, Andrew C., Roberts‐Thomson, Katherine M., Parker, L, Katherine M. Roberts‐Thomson, Keske, Michelle A., Glenn D. Wadley, Gatta, Paul A. Della, Marwick, TH, Betik, AC, Parker, Lewan, Paul A. Della Gatta   +20 more
core   +1 more source

Glucose metabolism and production of incretins in patients with obesity and type 2 diabetes mellitus after Biliopancreatic bypass surgery in the modification of Hess-Marceau the early stages of postoperative monitoring

Ожирение и метаболизм, 2015
Introduction: a significant improvement was shown in metabolic control at the early stages after BPD, which was associated with GLP-1 and was regardless of weight loss.Aim: to study the secretion of GLP-1, GIP, insulin and glucagon and their relationship
Ivan Ivanovich Dedov, Ekaterina Anatol'evna Troshina, Ekaterina Vladimirovna Ershova, Yuriy Ivanovich Yashkov   +3 more
doaj   +1 more source

Responses to GLP‐1RA in White and Black Adults With Obesity: Insights From Generalized Additive Mixed Models of EHR Data

Obesity, EarlyView.
ABSTRACT Objective This study examined racial differences in weight loss and clinical response to glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) therapy among adults with obesity using real‐world data. Methods We retrospectively analyzed our institution's Research Data Warehouse (RDW) containing deidentified data from electronic health records ...
Jordan H. Mallette, Joshua S. Speed, Seth T. Lirette, Daniel Moore, John S. Clemmer   +4 more
wiley   +1 more source

Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4

, 2017
Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is ...
Takayuki K. Nemoto, Yuko Ohara-Nemoto, Manami Nakasato, Ohara-Nemoto, Yuko, Shigenobu Kimura, Yaegashi, Takashi, Baba, Tomomi T., Ono, Toshio, Takeshi Kobayakawa, Nakasato, Manami, Toshio Ono, Nemoto, Takayuki K., Yu Shimoyama, Kobayakawa, Takeshi, Tomomi T. Baba, Kimura, Shigenobu, Shimoyama, Yu, Takashi Yaegashi   +17 more
core   +2 more sources

The Origin and Understanding of the Incretin Concept [PDF]

Frontiers in Endocrinology, 2018
Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy.
openaire   +4 more sources

Glucagon‐Like Peptide‐1 Receptor Agonist‐Based Agents and Body Composition: Filling More Gaps

Obesity, EarlyView.
ABSTRACT The last 2 decades have seen historic advances in the treatment of obesity. We are entering an era of defining obesity not by weight‐based outcomes but by changes in body composition. Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are forming the platform for obesity treatments based on their high level of efficacy. Body composition can
Robert L. Dubin, Tierra N. Sanders, Hunter M. Schwab, Steven B. Heymsfield, Frank L. Greenway   +4 more
wiley   +1 more source