Results 1 to 10 of about 22,320 (120)
Models for Incretin Research: From the Intestine to the Whole Body [PDF]
Endocrinology and Metabolism, 2016 Incretin hormones are produced by enteroendocrine cells (EECs) in the intestine in response to ingested nutrient stimuli. The incretin effect is defined as the difference in the insulin secretory response between the oral glucose tolerance test and an ...
Tae Jung Oh
doaj +1 more source
Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes. [PDF]
PLoS ONE, 2013 The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI).
Andrea Mari +5 more
doaj +1 more source
Exposure–Response Analysis of Cardiovascular Outcome Trials With Incretin-Based Therapies
Frontiers in Endocrinology, 2022 Our study aimed to evaluate the exposure–response relationship between incretin-based medications and the risk of major adverse cardiovascular events (MACE) using cardiovascular outcome trials (CVOTs).
Qi Pan, Mingxia Yuan, Lixin Guo
doaj +1 more source
Incretin Hormones: Pathophysiological Risk Factors and Potential Targets for Type 2 Diabetes
Journal of Obesity & Metabolic Syndrome, 2021 Type 2 diabetes (T2D) is a multifaceted metabolic disorder associated with distinctive pathophysiological disturbances. One of the pathophysiological risk factors observed in T2D is dysregulation of the incretin hormones, glucose-dependent insulinotropic
Jared Rosenberg +5 more
doaj +1 more source
Diagnostics, 2022 Elevated glucose-dependent insulinotropic peptide (GIP) levels in obesity may predict the metabolic benefits of n-3 PUFA supplementation. This placebo-controlled trial aimed to analyze fasting and postprandial GIP response to 3-month n-3 PUFA ...
Joanna Goralska +9 more
doaj +1 more source
Exenatide improves hepatocyte insulin resistance induced by different regional adipose tissue
Frontiers in Endocrinology, 2022 Obesity is resulted from energy surplus and is characterized by abnormal adipose tissue accumulation and/or distribution. Adipokines secreted by different regional adipose tissue can induce changes in key proteins of the insulin signaling pathway in ...
Chuanmin Bai +11 more
doaj +1 more source
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
JCI Insight, 2023 In youths with obesity, the gut hormone potentiation of insulin secretion — the incretin effect — is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on β cell function and insulin sensitivity.
Alfonso Galderisi +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Traumatic brain injury (TBI) is a commonly occurring injury in sports, victims of motor vehicle accidents, and falls. TBI has become a pressing public health concern with no specific therapeutic treatment.
Miaad Bader +13 more
doaj +1 more source
INCRETIN-BASED THERAPY AND CANCER: ARE THEY ENEMIES OR ALLIES? [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityThe link between cancer and diabetes is established but not fully understood. Incretin-based therapies have been increasingly used in the past decade for management of type 2 diabetes mellitus (T2DM).
Sandy Botros, Asmaa Matouk, Gehan Heeba
doaj +1 more source
Role of fasting duration and weekday in incretin and glucose regulation
Endocrine Connections, 2020 Fasting duration has been associated with lower fasting blood glucose levels, but higher 2-h post-load levels, and research has indicated an adverse effe ct of ‘weekend behavior’ on human metabolism.
Kim K B Clemmensen +11 more
doaj +1 more source