Results 1 to 10 of about 20,718 (120)
Models for Incretin Research: From the Intestine to the Whole Body [PDF]
Endocrinology and Metabolism, 2016 Incretin hormones are produced by enteroendocrine cells (EECs) in the intestine in response to ingested nutrient stimuli. The incretin effect is defined as the difference in the insulin secretory response between the oral glucose tolerance test and an ...
Tae Jung Oh
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Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes. [PDF]
PLoS ONE, 2013 The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI).
Andrea Mari +5 more
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Applied Phycology, 2021 In traditional medicine marine extracts are extensively used as therapies for diabetes. With the increasing rate of incidence of type 2 diabetes mellitus and rising cost of treatments, we investigated the anti-diabetic properties of extracts of common ...
Danielle Calderwood +9 more
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The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
Frontiers in Endocrinology, 2022 Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins
Melinda Danowitz +2 more
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Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes
Frontiers in Endocrinology, 2022 The incretin hormone glucagon-like peptide-1 (GLP-1) has received enormous attention during the past three decades as a therapeutic target for the treatment of obesity and type 2 diabetes.
Qiming Tan +7 more
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Vitae, 2022 Background: Diabetes mellitus treatment is based on oral hypoglycemic agents or insulin. Medicinal plants constitute an option, and the leaves of Prosopis ruscifolia (Pr) were shown to be effective in reducing glycemia in hyperglycemic animals. Objective:
María Luisa Kennedy +4 more
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Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
JCI Insight, 2023 In youths with obesity, the gut hormone potentiation of insulin secretion — the incretin effect — is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on β cell function and insulin sensitivity.
Alfonso Galderisi +8 more
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INCRETIN-BASED THERAPY AND CANCER: ARE THEY ENEMIES OR ALLIES? [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityThe link between cancer and diabetes is established but not fully understood. Incretin-based therapies have been increasingly used in the past decade for management of type 2 diabetes mellitus (T2DM).
Sandy Botros, Asmaa Matouk, Gehan Heeba
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Exposure–Response Analysis of Cardiovascular Outcome Trials With Incretin-Based Therapies
Frontiers in Endocrinology, 2022 Our study aimed to evaluate the exposure–response relationship between incretin-based medications and the risk of major adverse cardiovascular events (MACE) using cardiovascular outcome trials (CVOTs).
Qi Pan, Mingxia Yuan, Lixin Guo
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AN OVERVIEW OF INCRETIN-BASED THERAPIES: PHARMACOLOGY AND FUTURE PERSPECTIVES [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2022 Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that is released upon nutrient ingestion stimulating insulin secretion, suppressing glucagon secretion, and suppressing appetite and food intake which contribute to glucose homeostasis ...
Randa Ismail +3 more
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