Results 21 to 30 of about 20,867 (266)
Analytic framework for peptidomics applied to large-scale neuropeptide identification
Nature Communications, 2016 Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous ...
Anna Secher +6 more
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Glucagon Like Peptide 1 and Evidence Around Diabetes Specific Nutrition
World Nutrition, 2019 There has been significant research and development in pharmaco-therapeutic molecules for management of type 2 diabetes mellitus (T2DM). Diabetes specific nutrition intervention & newer incretin-based therapies have gained a lot of attention.
ANSHU JOSHI, SAMEER RAO, GANESH KADHE
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Frontiers in Cell and Developmental Biology, 2020 Traumatic brain injury (TBI) is a commonly occurring injury in sports, victims of motor vehicle accidents, and falls. TBI has become a pressing public health concern with no specific therapeutic treatment.
Miaad Bader +13 more
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Update on incretin hormones [PDF]
Annals of the New York Academy of Sciences, 2011 The incretin hormones glucagon‐like‐peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) are released from the intestine following oral ingestion of nutrients. Incretins promote insulin secretion, while GLP‐1 also inhibits glucagon release and gastric emptying, minimizing postprandial glucose excursions.
Phillips, Liza K., Prins, Johannes B.
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Pharmalogical effects and results of clinical trials of the first incretinomimetic exenatide
Сахарный диабет, 2011 The review is devoted to the pharmacological effects, the results of clinical trials, safety and the research perspectives of the first incretinomimetic ...
Alexander Sergeevich Ametov +1 more
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First GLP-1 analog liraglutide: the result of clinical trails on efficacy
Сахарный диабет, 2011 This review analytically considers the results of clinical trials on efficacy and safety and clinical perspectives of GLP-1 analog ...
Alexander Sergeevich Ametov +1 more
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Indian Journal of Endocrinology and Metabolism, 2012 Nutrient excess results in systemic inflammation in diabetes contributing to insulin resistance, dyslipidaemia and increased cardiovascular risk. GLP-1 agonists and DPP-4 inhibitors, which are now well accepted therapies for diabetes may play a unique role in modulating this inflammatory process.
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Role of fasting duration and weekday in incretin and glucose regulation
Endocrine Connections, 2020 Fasting duration has been associated with lower fasting blood glucose levels, but higher 2-h post-load levels, and research has indicated an adverse effe ct of ‘weekend behavior’ on human metabolism.
Kim K B Clemmensen +11 more
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AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration. [PDF]
PLoS ONE, 2013 The precise role of AMP-activated protein kinase (AMPK), a target of metformin, in pancreatic β cells remains controversial, even though metformin was recently shown to enhance the expression of incretin receptors (GLP-1 and GIP receptors) in pancreatic ...
Kazuki Tajima +13 more
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Variation in responses to incretin therapy: Modifiable and non-modifiable factors
Frontiers in Molecular Biosciences, 2023 Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss.
Gregory O. Austin, Alejandra Tomas
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