Results 11 to 20 of about 22,370 (168)
To be or not to be—an incretin or enterogastrone? [PDF]
Gut, 2006 Glucagon-like peptide 1 does not comfortably fulfil the criterion of a gut derived factor responsible for an enhanced meal related insulin response; it appears logical to add the definition of a "physiological incretin hormone".
Horowitz, M., Nauck, M.
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Incretin‐based therapies [PDF]
Journal of Diabetes, 2012 AbstractIncretin‐based therapies have established a foothold in the diabetes armamentarium through the introduction of oral dipeptidyl peptidase‐4 inhibitors and the injectable class, the glucagon‐like peptide‐1 receptor agonists. In 2009, the American Diabetes Association and European Association for the Study of Diabetes authored a revised consensus ...
Stonehouse, Anthony H +2 more
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Incretins or Anti-Incretins? A New Model for the “Entero-Pancreatic Axis” [PDF]
Hormone and Metabolic Research, 2014 The role of incretins in glucose homeostasis is well known. Yet, in recent years, the sustained weight loss and rapid glycemic control following bariatric surgery has challenged our understanding of the intestinal-pancreatic interaction. This in turn led to the introduction of metabolic surgery, an innovative medical discipline in which a surgical ...
Kamvissi, V +4 more
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Applied Phycology, 2021 In traditional medicine marine extracts are extensively used as therapies for diabetes. With the increasing rate of incidence of type 2 diabetes mellitus and rising cost of treatments, we investigated the anti-diabetic properties of extracts of common ...
Danielle Calderwood +9 more
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AN OVERVIEW OF INCRETIN-BASED THERAPIES: PHARMACOLOGY AND FUTURE PERSPECTIVES [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2022 Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that is released upon nutrient ingestion stimulating insulin secretion, suppressing glucagon secretion, and suppressing appetite and food intake which contribute to glucose homeostasis ...
Randa Ismail +3 more
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The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
Frontiers in Endocrinology, 2022 Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins
Melinda Danowitz +2 more
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Genetic variants affecting incretin sensitivity and incretin secretion [PDF]
Diabetologia, 2010 Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these type 2 diabetes risk variants confer impaired pancreatic beta cell function. Though the molecular mechanisms by which common genetic variation within these loci affects beta cell function are not completely understood, risk variants may
K, Müssig +4 more
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Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes
Frontiers in Endocrinology, 2022 The incretin hormone glucagon-like peptide-1 (GLP-1) has received enormous attention during the past three decades as a therapeutic target for the treatment of obesity and type 2 diabetes.
Qiming Tan +7 more
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Analytic framework for peptidomics applied to large-scale neuropeptide identification
Nature Communications, 2016 Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous ...
Anna Secher +6 more
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Vitae, 2022 Background: Diabetes mellitus treatment is based on oral hypoglycemic agents or insulin. Medicinal plants constitute an option, and the leaves of Prosopis ruscifolia (Pr) were shown to be effective in reducing glycemia in hyperglycemic animals. Objective:
María Luisa Kennedy +4 more
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