Results 11 to 20 of about 21,074 (263)

Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity

JCI Insight, 2023
In youths with obesity, the gut hormone potentiation of insulin secretion — the incretin effect — is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on β cell function and insulin sensitivity.
Alfonso Galderisi, Domenico Tricò, Jessica Lat, Stephanie Samuels, Ram Weiss, Michelle Van Name, Bridget Pierpont, Nicola Santoro, Sonia Caprio   +8 more
doaj   +1 more source

Exenatide improves hepatocyte insulin resistance induced by different regional adipose tissue

Frontiers in Endocrinology, 2022
Obesity is resulted from energy surplus and is characterized by abnormal adipose tissue accumulation and/or distribution. Adipokines secreted by different regional adipose tissue can induce changes in key proteins of the insulin signaling pathway in ...
Chuanmin Bai, Yujun Wang, Zhi Niu, Yaxin Guan, Jingshan Huang, Xin Nian, Fan Zuo, Juan Zhao, Tsutomu Kazumi, Tsutomu Kazumi, Tsutomu Kazumi, Bin Wu   +11 more
doaj   +1 more source

Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury

Frontiers in Cell and Developmental Biology, 2020
Traumatic brain injury (TBI) is a commonly occurring injury in sports, victims of motor vehicle accidents, and falls. TBI has become a pressing public health concern with no specific therapeutic treatment.
Miaad Bader, Yazhou Li, David Tweedie, Nathan A. Shlobin, Adi Bernstein, Vardit Rubovitch, Luis B. Tovar-y-Romo, Luis B. Tovar-y-Romo, Richard D. DiMarchi, Barry J. Hoffer, Nigel H. Greig, Chaim G. Pick, Chaim G. Pick, Chaim G. Pick   +13 more
doaj   +1 more source

INCRETIN-BASED THERAPY AND CANCER: ARE THEY ENEMIES OR ALLIES? [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
The link between cancer and diabetes is established but not fully understood. Incretin-based therapies have been increasingly used in the past decade for management of type 2 diabetes mellitus (T2DM).
Sandy Botros, Asmaa Matouk, Gehan Heeba
doaj   +1 more source

Role of fasting duration and weekday in incretin and glucose regulation

Endocrine Connections, 2020
Fasting duration has been associated with lower fasting blood glucose levels, but higher 2-h post-load levels, and research has indicated an adverse effe ct of ‘weekend behavior’ on human metabolism.
Kim K B Clemmensen, Jonas S Quist, Dorte Vistisen, Daniel R Witte, Anna Jonsson, Oluf Pedersen, Torben Hansen, Jens J Holst, Torsten Lauritzen, Marit E Jørgensen, Signe Torekov, Kristine Færch   +11 more
doaj   +1 more source

Incretins or Anti-Incretins? A New Model for the “Entero-Pancreatic Axis” [PDF]

Hormone and Metabolic Research, 2014
The role of incretins in glucose homeostasis is well known. Yet, in recent years, the sustained weight loss and rapid glycemic control following bariatric surgery has challenged our understanding of the intestinal-pancreatic interaction. This in turn led to the introduction of metabolic surgery, an innovative medical discipline in which a surgical ...
Kamvissi, V, Salerno, A, Bornstein, Sr, Mingrone, Geltrude, Rubino, F.   +4 more
openaire   +4 more sources

AN OVERVIEW OF INCRETIN-BASED THERAPIES: PHARMACOLOGY AND FUTURE PERSPECTIVES [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2022
Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that is released upon nutrient ingestion stimulating insulin secretion, suppressing glucagon secretion, and suppressing appetite and food intake which contribute to glucose homeostasis ...
Randa Ismail, Aliaa Anter, I. Matouk, Gehan Heeba   +3 more
doaj   +1 more source

Genetic variants affecting incretin sensitivity and incretin secretion [PDF]

Diabetologia, 2010
Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these type 2 diabetes risk variants confer impaired pancreatic beta cell function. Though the molecular mechanisms by which common genetic variation within these loci affects beta cell function are not completely understood, risk variants may
K, Müssig, H, Staiger, F, Machicao, H-U, Häring, A, Fritsche   +4 more
openaire   +2 more sources

AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration. [PDF]

PLoS ONE, 2013
The precise role of AMP-activated protein kinase (AMPK), a target of metformin, in pancreatic β cells remains controversial, even though metformin was recently shown to enhance the expression of incretin receptors (GLP-1 and GIP receptors) in pancreatic ...
Kazuki Tajima, Jun Shirakawa, Yu Togashi, Hideaki Inoue, Koichiro Sato, Kazuki Orime, Yuzuru Ito, Mitsuyo Kaji, Eri Sakamoto, Akinobu Nakamura, Kazutaka Aoki, Yoshio Goshima, Tatsuya Atsumi, Yasuo Terauchi   +13 more
doaj   +1 more source

Profiling the activity of edible European macroalgae towards pharmacological targets for type 2 diabetes mellitus

Applied Phycology, 2021
In traditional medicine marine extracts are extensively used as therapies for diabetes. With the increasing rate of incidence of type 2 diabetes mellitus and rising cost of treatments, we investigated the anti-diabetic properties of extracts of common ...
Danielle Calderwood, Eamon Rafferty, Ciaran Fitzgerald, Velizara Stoilova, Alastair Wylie, Brendan F. Gilmore, Francisco Castaneda, Alvaro Israel, Christine A. Maggs, Brian D. Green   +9 more
doaj   +1 more source