Results 31 to 40 of about 3,377,180 (268)

Effects of passage through the digestive tract on incretin secretion: Before and after birth

Journal of Diabetes Investigation, 2021
Aims/Introduction It was reported that fetuses secrete endogenous incretin; however, the stimulants of fetal incretin secretion are not fully understood.
Seiichi Tomotaki, Ryosuke Araki, Kouji Motokura, Yutaro Tomobe, Takeru Yamauchi, Shintaro Hanaoka, Hiroko Tomotaki, Kougoro Iwanaga, Fusako Niwa, Junko Takita, Masahiko Kawai   +10 more
doaj   +1 more source

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

eLife, 2021
Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone that exerts crucial metabolic functions by binding and activating its cognate receptor, GIPR.
Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dan-Dan Shen, Yan Zhang, Tian Xia, Raymond C Stevens, H Eric Xu, Dehua Yang, Lihua Zhao, Ming-Wei Wang   +17 more
doaj   +1 more source

Glucose-Dependent Insulinotropic Polypeptide Plasma Level Influences the Effect of n-3 PUFA Supplementation

Diagnostics, 2022
Elevated glucose-dependent insulinotropic peptide (GIP) levels in obesity may predict the metabolic benefits of n-3 PUFA supplementation. This placebo-controlled trial aimed to analyze fasting and postprandial GIP response to 3-month n-3 PUFA ...
Joanna Goralska, Urszula Razny, Philip C. Calder, Anna Gruca, Caroline E. Childs, Piotr Zabielski, Aldona Dembinska-Kiec, Maciej Banach, Bogdan Solnica, Malgorzata Malczewska-Malec   +9 more
doaj   +1 more source

Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function

Frontiers in Endocrinology, 2017
Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract, and muscle, regulating pancreatic secretion through cellular receptors and their signal transduction cascades.
Iacopo Gesmundo, Tania Villanova, Dana Banfi, Giacomo Gamba, Riccarda Granata   +4 more
doaj   +1 more source

Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: Effects on weight loss and safety in adults with overweight or obesity

Molecular Metabolism, 2023
Objective: Glucagon/glucagon-like peptide-1 (GLP-1) receptor co-agonists may provide greater weight loss than agonists targeting the GLP-1 receptor alone.
Martin Haljeta Friedrichsen, Lars Endahl, Frederik Flindt Kreiner, Ronald Goldwater, Martin Kankam, Søren Toubro, Sune Boris Nygård   +6 more
doaj   +1 more source

β-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts

Bone Reports, 2021
Osteoblast lysyl oxidase (LOX) is a strongly up-regulated mRNA and protein by the glucose-dependent insulinotropic polypeptide (GIP). LOX is critically required for collagen maturation, and was shown to be dramatically down-regulated in a mouse model of ...
Eileen J. Daley, Philip C. Trackman
doaj   +1 more source

HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide [PDF]

Scientific Reports, 2019
AbstractMutations in the HNF4A gene cause MODY1 and are associated with an increased risk of Type 2 diabetes mellitus. On the other hand, incretins are hormones that potentiate reductions in blood glucose levels. Given the established role of incretin-based therapy to treat diabetes and metabolic disorders, we investigated a possible regulatory link ...
Girard, Romain, Darsigny, Mathieu, Jones, Christine, Maloum-Rami, Faïza, Gélinas, Yves, Carpentier, André C., Laplante, Mathieu, Perreault, Nathalie, Boudreau, François   +8 more
openaire   +2 more sources

Glucose-dependent insulinotropic polypeptide - a new link in the development of obesity

Ожирение и метаболизм, 2015
Objective. Glucose-dependent insulinotropic polypeptide (GIP) as well as glucagon-like peptide-1 (GLP-1) is intestinal incretin hormone that stimulates insulin secretion in response to feeding. Much evidence of GIP contribution to obesity development has
Ekaterina Alekseevna Shestakova, Aleksandr Victorovich Il'in, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov   +3 more
doaj   +1 more source

Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic γ cells.

PLoS ONE, 2022
Pancreatic polypeptide (PP), secreted from γ cells of the islets of Langerhans, is a 36 amino-acid peptide encoded by the Ppy gene. Although previous studies have reported that PP causes a decrease in appetite, the molecular mechanism that regulates PP ...
Daisuke Saito, Yuko Nakagawa, Takashi Sato, Ayako Fukunaka, Ofejiro Blessing Pereye, Nobuhiro Maruyama, Hirotaka Watada, Yoshio Fujitani   +7 more
doaj   +1 more source

Development and validation of novel fluorescent probes to advance research into glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP1) receptor localisation and activity [PDF]

Diabetes and obesity are chronic conditions which cause significant impact upon the individual, healthcare services and society. Medications agonising glucagon-like peptide-1 receptor (GLP1R) and dual agonists targeting GLP1R and glucose-dependent ...
De Bray, Anne Yingchol
core   +1 more source