Results 31 to 40 of about 13,497 (214)

Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: Effects on weight loss and safety in adults with overweight or obesity

Molecular Metabolism, 2023
Objective: Glucagon/glucagon-like peptide-1 (GLP-1) receptor co-agonists may provide greater weight loss than agonists targeting the GLP-1 receptor alone.
Martin Haljeta Friedrichsen, Lars Endahl, Frederik Flindt Kreiner, Ronald Goldwater, Martin Kankam, Søren Toubro, Sune Boris Nygård   +6 more
doaj   +1 more source

Increased glucose-dependent insulinotropic polypeptide (GIP) secretion in acromegaly [PDF]

European Journal of Endocrinology, 2001
OBJECTIVE: Acromegaly is often associated with fasting and postprandial hyperinsulinemia, and the mechanisms involved are only partly understood. Hypersecretion of incretins such as glucose-dependent insulinotropic polypeptide (GIP) could play a role in determining hyperinsulinemia in acromegaly, but the available data are inconsistent. The aim of this
M. Peracchi, S. Porretti, C. Gebbia, C. Pagliari, P. Bucciarelli, P. Epaminonda, S. Manenti, M. Arosio   +7 more
openaire   +4 more sources

Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic γ cells.

PLoS ONE, 2022
Pancreatic polypeptide (PP), secreted from γ cells of the islets of Langerhans, is a 36 amino-acid peptide encoded by the Ppy gene. Although previous studies have reported that PP causes a decrease in appetite, the molecular mechanism that regulates PP ...
Daisuke Saito, Yuko Nakagawa, Takashi Sato, Ayako Fukunaka, Ofejiro Blessing Pereye, Nobuhiro Maruyama, Hirotaka Watada, Yoshio Fujitani   +7 more
doaj   +1 more source

Anti‐inflammatory role of glucose‐dependent insulinotropic polypeptide in periodontitis [PDF]

Journal of Diabetes Investigation, 2016
AbstractAims/IntroductionThe involvement of glucose‐dependent insulinotropic polypeptide (GIP) on inflammation was explored in atherosclerosis and adipose tissue. Periodontal disease is a chronic inflammatory disease, and is considered one of the diabetic complications.
Suzuki, Yuki, Nakamura, Nobuhisa, Miyabe, Megumi, Nishikawa, Toru, Miyajima, Shin‐ichi, Adachi, Kei, Mizutani, Makoto, Kikuchi, Takeshi, Miyazawa, Ken, Goto, Shigemi, Tsukiyama, Katsushi, Yamada, Yuichiro, Ohno, Norikazu, Noguchi, Toshihide, Mitani, Akio, Matsubara, Tatsuaki, Naruse, Keiko   +16 more
openaire   +2 more sources

Glucose-Dependent Insulinotropic Polypeptide Inhibits Bone Resorption in Humans [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2014
In humans, the pronounced postprandial reduction in bone resorption (decreasing bone resorption markers by around 50%) has been suggested to be caused by gut hormones. Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone secreted postprandially from the small intestine.
Nissen, Anne, Christensen, Mikkel, Knop, Filip K, Vilsbøll, Tina, Holst, Jens Juul, Hartmann, Bolette   +5 more
openaire   +3 more sources

Glucose-dependent insulinotropic polypeptide - a new link in the development of obesity

Ожирение и метаболизм, 2015
Objective. Glucose-dependent insulinotropic polypeptide (GIP) as well as glucagon-like peptide-1 (GLP-1) is intestinal incretin hormone that stimulates insulin secretion in response to feeding. Much evidence of GIP contribution to obesity development has
Ekaterina Alekseevna Shestakova, Aleksandr Victorovich Il'in, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov   +3 more
doaj   +1 more source

β-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts

Bone Reports, 2021
Osteoblast lysyl oxidase (LOX) is a strongly up-regulated mRNA and protein by the glucose-dependent insulinotropic polypeptide (GIP). LOX is critically required for collagen maturation, and was shown to be dramatically down-regulated in a mouse model of ...
Eileen J. Daley, Philip C. Trackman
doaj   +1 more source

The study of metabolic improvement by nutritional intervention controlling endogenous GIP (Mini Egg study): a randomized, cross-over study

Nutrition Journal, 2019
Background Given the major role of glucose-dependent insulinotropic polypeptide (GIP) in the regulation of adiposity, this study examined the effects induced by a diet based on the Japanese tradition (SMART WASHOKU) on the visceral fat area (VFA) and GIP
Naoki Sakane, Noriko Osaki, Hideto Takase, Junko Suzuki, Chika Suzukamo, Shinsuke Nirengi, Akiko Suganuma, Akira Shimotoyodome   +7 more
doaj   +1 more source

ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets

Molecules and Cells
: Insulin is essential for maintaining normoglycemia and is predominantly secreted in response to glucose stimulation by β-cells. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, also stimulate ...
Yurong Gao, Hanguk Ryu, Hyejin Lee, Young-Joon Kim, Ji-Hye Lee, Jaemin Lee   +5 more
doaj   +1 more source

The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury

Cardiovascular Diabetology, 2022
Background The gut incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by enteroendocrine cells following food intake leading to insulin secretion and glucose lowering.
Florian Kahles, Matthias Rau, Martin Reugels, Ann C. Foldenauer, Robert W. Mertens, Maria C. Arrivas, Jörg Schröder, Paul Idel, Julia Moellmann, Emiel P. C. van der Vorst, Nikolaus Marx, Michael Lehrke   +11 more
doaj   +1 more source