Results 21 to 30 of about 140,006 (312)

The Enigmatic N-Terminal Domain of Proglucagon; A Historical Perspective

Frontiers in Endocrinology, 2021
Enteroglucagon refers to the predominant peptide with glucagon-like immunoreactivity (GLI) that is released by the intestine into the circulation in response to nutrients.
J. Michael Conlon
doaj   +1 more source

Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion [PDF]

, 2010
Context: Glucagon-like peptide-1 (GLP-1) is produced by specialized cells in the gut and secreted in response to carbohydrates and lipids. The mechanisms regulating fat-stimulated GLP-1 release have, however, not been clarified in detail.
Schirra, Joerg, D'Amato, Massimo, Göke, Burkhard, Drewe, Juergen, Beglinger, Svetlana, Beglinger, Christoph   +5 more
core   +1 more source

A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs

Frontiers in Endocrinology, 2021
Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics.
Rongjun He, Stephanie A. Mowery, Joseph Chabenne, Brian Finan, John P. Mayer, Richard D. DiMarchi   +5 more
doaj   +1 more source

Glucagon-like peptide analogues for type 2 diabetes mellitus : systematic review and meta-analysis [PDF]

, 2010
Background Glucagon-like peptide (GLP-1) analogues are a new class of drugs used in the treatment of type 2 diabetes. They are given by injection, and regulate glucose levels by stimulating glucose-dependent insulin secretion and biosynthesis ...
Deepson S Shyangdan, Christine Clar, Pawana Sharma, Royle, Pamela L, Sharma Pawana, Royle Pamela L, Clar, Christine, Clar, C., Waugh, Norman R, Waugh Norman R, Pamela L Royle, Shyangdan Deepson S, Clar Christine, Waugh, Norman, Norman R Waugh, Sharma, Pawana, Shyangdan, D. (Deepson), Shyangdan, Deepson S, Royle, Pamela   +18 more
core   +1 more source

Changing paradigms in type 2 diabetes mellitus

Indian Journal of Endocrinology and Metabolism, 2013
Diabetes mellitus has been increasing in prevalence and imposes serious economic burdens on both the developed as well as the developing world. Understanding pathobiological underpinning of chronic progressive disease like diabetes is an imperative that ...
Romesh Khardori
doaj   +1 more source

Hypothalamically-Induced Insulin Release and its Potentiation During Oral and Intravenous Glucose Loads [PDF]

, 1984
Male Wistar rats were provided with bilateral cannulas in the lateral hypothalamic area (LHA) and cannulas in the left and right jugular vein. Freely moving rats provided in this way with cannulas were infused with transmitters in the LHA and with ...
Steffens, A.B., Steffens, A.B.,, Luiten, P.G.M., Kuipers, F.; id_orcid, Luiten, P.G.M.,, Flik, G., Flik, G.,, Kuipers, F.,, Kuipers, F., Lotter, E.C., Lotter, E.C.,   +10 more
core   +1 more source

Assessing the Effect of Incretin Hormones and Other Insulin Secretagogues on Pancreatic Beta-Cell Function: Review on Mathematical Modelling Approaches

Biomedicines, 2022
Mathematical modelling in glucose metabolism has proven very useful for different reasons. Several models have allowed deeper understanding of the relevant physiological and pathophysiological aspects and promoted new experimental activity to reach ...
Giovanni Pacini, Bo Ahrén, Christian Göbl, Andrea Tura   +3 more
doaj   +1 more source

Agreement between fingertip-capillary and antecubital-venous appetite-related peptides [PDF]

, 2014
Background: The present study examined the agreement between fingertip-capillary and antecubital-venous measures of appetite-related peptides. Methods: Simultaneous fingertip-capillary and antecubital-venous blood samples were collected from 19 ...
Stevenson, Emma, Gonzalez, Javier Thomas, Rumbold, Penny Louise Sheena, Thomas, Kevin, Green, Benjamin, Green, Benjamin Paul, Gonzalez, Javier, Rumbold, Penny   +7 more
core   +1 more source

Glucagon Reduces Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice

Frontiers in Immunology, 2021
Sepsis is one of the most common comorbidities observed in diabetic patients, associated with a deficient innate immune response. Recently, we have shown that glucagon possesses anti-inflammatory properties.
Daniella Bianchi Reis Insuela, Maximiliano Ruben Ferrero, Cassiano Felippe Gonçalves-de-Albuquerque, Cassiano Felippe Gonçalves-de-Albuquerque, Amanda da Silva Chaves, Adriano Yagho Oliveira da Silva, Hugo Caire Castro-Faria-Neto, Hugo Caire Castro-Faria-Neto, Rafael Loureiro Simões, Thereza Christina Barja-Fidalgo, Patricia Machado Rodrigues e Silva, Marco Aurélio Martins, Adriana Ribeiro Silva, Adriana Ribeiro Silva, Vinicius Frias Carvalho, Vinicius Frias Carvalho   +15 more
doaj   +1 more source

Glucagon Antibodies and Their Use for Immunoassay for Glucagon.

Experimental Biology and Medicine, 1959
SummaryNon-precipitating antibodies to glucagon have been produced in rabbits and detected by both Berson-Yalow and Skom-Talmadge technics.
R H, UNGER, A M, EISENTRAUT, M S, McCALL, S, KELLER, H C, LANZ, L L, MADISON   +5 more
openaire   +2 more sources