Results 11 to 20 of about 114,449 (265)
The relationship between glucose and the liver-alpha cell axis – A systematic review
Frontiers in Endocrinology, 2023 Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop.
Thomas Pixner +23 more
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Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion
Frontiers in Endocrinology, 2022 As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by enhancing glucose-stimulated insulin secretion from pancreatic beta-cells.
Marlena M. Holter +3 more
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Glucagon Receptor Signaling and Glucagon Resistance [PDF]
International Journal of Molecular Sciences, 2019 Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas).
Lina Janah +8 more
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In vitro assessment of pancreatic hormone secretion from isolated porcine islets
Frontiers in Endocrinology, 2022 The potential use of porcine islets for transplantation in humans has triggered interest in understanding porcine islet physiology. However, the number of studies dedicated to this topic has remained limited, as most islet physiologists prefer to use the
Nizar I. Mourad +2 more
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Glucagonoma without glucagonoma syndrome [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2010 Introduction. Glucagonomas are rare, frequently malignant tumours, arising from the Langerhans' islets of the pancreas. They usually secrete large amounts of glucagon that can cause a characteristic 'glucagonoma syndrome', which includes necrolytic ...
Čolović Radoje +4 more
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The Enigmatic N-Terminal Domain of Proglucagon; A Historical Perspective
Frontiers in Endocrinology, 2021 Enteroglucagon refers to the predominant peptide with glucagon-like immunoreactivity (GLI) that is released by the intestine into the circulation in response to nutrients.
J. Michael Conlon
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Frontiers in Endocrinology, 2021 Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics.
Rongjun He +5 more
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Changing paradigms in type 2 diabetes mellitus
Indian Journal of Endocrinology and Metabolism, 2013 Diabetes mellitus has been increasing in prevalence and imposes serious economic burdens on both the developed as well as the developing world. Understanding pathobiological underpinning of chronic progressive disease like diabetes is an imperative that ...
Romesh Khardori
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Biomedicines, 2022 Mathematical modelling in glucose metabolism has proven very useful for different reasons. Several models have allowed deeper understanding of the relevant physiological and pathophysiological aspects and promoted new experimental activity to reach ...
Giovanni Pacini +3 more
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Glucagon Reduces Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice
Frontiers in Immunology, 2021 Sepsis is one of the most common comorbidities observed in diabetic patients, associated with a deficient innate immune response. Recently, we have shown that glucagon possesses anti-inflammatory properties.
Daniella Bianchi Reis Insuela +15 more
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