Results 11 to 20 of about 140,006 (312)

Glucagon Receptor Signaling and Glucagon Resistance [PDF]

International Journal of Molecular Sciences, 2019
Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas).
Lina Janah, Sasha Kjeldsen, Katrine D. Galsgaard, Marie Winther-Sørensen, Elena Stojanovska, Jens Pedersen, Filip K. Knop, Jens J. Holst, Nicolai J. Wewer Albrechtsen   +8 more
openaire   +5 more sources

Glucagon receptors

Cellular and Molecular Life Sciences, 2008
Glucagon is a pancreatic peptide hormone that, as a counterregulatory hormone for insulin, stimulates glucose release by the liver and maintains glucose homeostasis. First described as a glucagon binding entity functionally linked to adenylyl cyclase, the glucagon receptor is a member of the family B receptors within the G protein coupled superfamily ...
Authier, François, Desbuquois, Bernard
openaire   +5 more sources

Glucagon and Glucagon-Like Peptides 1 and 2

, 2009
The glucagon gene is expressed not only in the alpha cells of the pancreatic islets but also in the endocrine cells of the intestinal epithelium (so-called L-cells), and in certain neurons of the brain stem. Whereas in the pancreas, glucagon, the hyperglycaemic hormone, is cleaved out of the 160 amino acid precursor, proglucagon, leaving behind ...
Jens Juul Holst, Holst, Jens Juul
openaire   +4 more sources

The relationship between glucose and the liver-alpha cell axis – A systematic review

Frontiers in Endocrinology, 2023
Until recently, glucagon was considered a mere antagonist to insulin, protecting the body from hypoglycemia. This notion changed with the discovery of the liver-alpha cell axis (LACA) as a feedback loop.
Thomas Pixner, Thomas Pixner, Nathalie Stummer, Nathalie Stummer, Anna Maria Schneider, Anna Maria Schneider, Andreas Lukas, Andreas Lukas, Karin Gramlinger, Valérie Julian, David Thivel, Katharina Mörwald, Katharina Mörwald, Harald Mangge, Christopher Dalus, Christopher Dalus, Elmar Aigner, Elmar Aigner, Dieter Furthner, Dieter Furthner, Daniel Weghuber, Daniel Weghuber, Katharina Maruszczak, Katharina Maruszczak   +23 more
doaj   +1 more source

Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

Frontiers in Endocrinology, 2022
As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by enhancing glucose-stimulated insulin secretion from pancreatic beta-cells.
Marlena M. Holter, Mridusmita Saikia, Mridusmita Saikia, Bethany P. Cummings   +3 more
doaj   +1 more source

Glucagon-like peptide-1 receptor imaging for localization of insulinomas [PDF]

, 2009
The surgical removal of insulinomas is hampered by difficulties to localize it using conventional radiological procedures. Recently these tumors were shown to exhibit a very high density of glucagon-like peptide-1 receptors (GLP-1R) in vitro that may be ...
Clerici, Thomas, Forrer, Flavio, Gloor, Beat, Reubi, Jean Claude, Rahel Sahli, Mäcke, Helmut R., Brändle, Michael, Beat Gloor, Martius, Ferdinand, Damian Wild, Reubi, Jean-Claude, Thomas Clerici, Flavio Forrer, Maecke, Helmut, Wild, Damian, Emanuel Christ, Ferdinand Martius, Christ, Emanuel, Sahli, Rahel, Jean Claude Reubi, Michael Brändle, Helmut Maecke   +21 more
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Contribution of liver nerves, glucagon, and adrenaline to the glycaemic response to exercise in rats [PDF]

, 1994
The contribution of hepatic sympathetic innervation, glucagon and adrenaline to the glycaemic response to exercise was investigated in rats. Hepatically denervated (LDX) or sham operated (SHAM) rats with permanent catheters were therefore submitted to ...
B. AHRÉN, Dijk, G. van,, Bouws, G., van Dijk, Gertjan; id_orcid, Ahrén, B., Lindfeldt, J., KUVAKİ BALKAN, BAHAR, Bouws, G.,, SCHEURINK, AJW, AHREN, B, Balkan, B.,, Balkan, B., A. J. W. SCHEURINK, VAN DIJK, G, BOUWS, G, LINDFELDT, J, Scheurink, A.J.W., BALKAN, B, STEFFENS, AB, G. BOUWS, Steffens, A.B.,, B. BALKAN, Ahrén, B.,, Scheurink, A.J.W.,, A. B. STEFFENS, Steffens, A.B., Lindfeldt, J.,, G. VAN DIJK, van Dijk, Gertjan, VANDIJK, G, J. LINDFELDT   +30 more
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An Evaluation of Glucagon Injection Anxiety and Its Association with the Fear of Hypoglycemia among the Parents of Children with Type 1 Diabetes [PDF]

, 2021
Objective:Hypoglycemia is a common acute complication of type 1 diabetes (T1D), which may cause seizure, loss of consciousness, and temporary motor or sensory impairment.
Şükrü Hatun, Serra Muradoğlu, Ecem Can, Gül Yeşiltepe Mutlu, Tuğba Gökçe   +4 more
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In vitro assessment of pancreatic hormone secretion from isolated porcine islets

Frontiers in Endocrinology, 2022
The potential use of porcine islets for transplantation in humans has triggered interest in understanding porcine islet physiology. However, the number of studies dedicated to this topic has remained limited, as most islet physiologists prefer to use the
Nizar I. Mourad, Daela Xhema, Pierre Gianello   +2 more
doaj   +1 more source

Glucagonoma without glucagonoma syndrome [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. Glucagonomas are rare, frequently malignant tumours, arising from the Langerhans' islets of the pancreas. They usually secrete large amounts of glucagon that can cause a characteristic 'glucagonoma syndrome', which includes necrolytic ...
Čolović Radoje, Matić Slavko, Micev Marjan, Grubor Nikica, Latinčić Stojan   +4 more
doaj   +1 more source